Grupos Investigadores

Líneas de Investigación

  • Diseño de experimentos: clásico y óptimo
  • Modelización: Modelos lineales, lineales generalizados y no lineales; modelos mixtos; selección de variables; discriminación de modelos; modelos no paramétricos; modelos bayesianos; estadística espacio-temporal.
  • Muestreo; diseño, validación y análisis de encuestas.
  • Métodos cuantitativos en el tratamiento de datos experimentales.
  • Técnicas estadísticas de tratamiento de Big Data: Reducción de variables; modelos de clasificación; algoritmos heurísticos y meta-heurísticos de optimización, Machine Learning; aplicación del diseño de experimentos en la búsqueda de máxima información.

Palabras Clave

  • Diseño de experimentos
  • Encuestas
  • Estadística Bayesiana
  • Machine Learning
  • Modelización
  • Muestreo
  • Tratamiento Estadístico de Big Data

Publicaciones Científicas desde 2018

  • Autores: Benítez Sastoque, Edgar Ricardo; López Fidalgo, Jesús Fernando
    Revista: JOURNAL OF CHEMOMETRICS (ONLINE)
    ISSN: 1099-128X Vol.38 N° 1 2024 págs. e3525
    Resumen
    The state of the art related to parameter correlation in two-parameter models has been reviewed in this paper. The apparent contradictions between the different authors regarding the ability of D-optimality to simultaneously reduce the correlation and the area of the confidence ellipse in two-parameter models were analyzed. Two main approaches were found: (1) those who consider that the optimality criteria simultaneously control the precision and correlation of the parameter estimators and (2) those that consider a combination of criteria to achieve the same objective. An analytical criterion combining in its structure both the optimality of the precision of the estimators of the parameters and the reduction of the correlation between their estimators is provided. The criterion was tested both in a simple linear regression model, considering all possible design spaces, and in a nonlinear model with strong correlation of the estimators of the parameters (Michaelis¿Menten) to show its performance. This criterion showed a superior behavior to all the strategies and criteria to control at the same time the precision and the correlation.
  • Autores: Hangel, G. (Autor de correspondencia); Schmitz-Abecassis, B.; Sollmann, N.; et al.
    Revista: JOURNAL OF MAGNETIC RESONANCE IMAGING
    ISSN: 1053-1807 Vol.57 N° 6 2023 págs. 1676 - 1695
    Resumen
    Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible clinical translation. This review describes current methods, limits, and applications of advanced MRI for the preoperative assessment of glioma, summarizing the level of clinical validation of different techniques. In this second part, we review magnetic resonance spectroscopy (MRS), chemical exchange saturation transfer (CEST), susceptibility-weighted imaging (SWI), MRI-PET, MR elastography (MRE), and MR-based radiomics applications. The first part of this review addresses dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL), diffusion-weighted MRI, vessel imaging, and magnetic resonance fingerprinting (MRF). Evidence Level3. Technical EfficacyStage 2.
  • Autores: Hirschler, L.; Sollmann, N.; Schmitz-Abecassis, B.; et al.
    Revista: JOURNAL OF MAGNETIC RESONANCE IMAGING
    ISSN: 1053-1807 Vol.57 N° 6 2023 págs. 1655 - 1675
    Resumen
    Preoperative clinical magnetic resonance imaging (MRI) protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible clinical translation or lack thereof. This review describes current methods, limits, and applications of advanced MRI for the preoperative assessment of glioma, summarizing the level of clinical validation of different techniques. In this first part, we discuss dynamic susceptibility contrast and dynamic contrast-enhanced MRI, arterial spin labeling, diffusion-weighted MRI, vessel imaging, and magnetic resonance fingerprinting. The second part of this review addresses magnetic resonance spectroscopy, chemical exchange saturation transfer, susceptibility-weighted imaging, MRI-PET, MR elastography, and MR-based radiomics applications.Evidence Level: 3Technical Efficacy: Stage 2
  • Autores: Aramendia Vidaurreta, Verónica; Solís-Barquero, S. M.; Ezponda Casajús, Ana; et al.
    Revista: JOURNAL OF MAGNETIC RESONANCE IMAGING
    ISSN: 1053-1807 Vol.58 N° 1 2023 págs. 147 - 156
    Resumen
    Background In patients with suspected coronary artery disease (CAD), myocardial perfusion is assessed under rest and pharmacological stress to identify ischemia. Splenic switch-off, defined as the stress to rest splenic perfusion attenuation in response to adenosine, has been proposed as an indicator of stress adequacy. Its occurrence has been previously assessed in first-pass perfusion images, but the use of noncontrast techniques would be highly beneficial. Purpose To explore the ability of pseudo-continuous arterial spin labeling (PCASL) to identify splenic switch-off in patients with suspected CAD. Study Type Prospective. Population Five healthy volunteers (age 24.8 +/- 3.8 years) and 32 patients (age 66.4 +/- 8.2 years) with suspected CAD. Field strength/Sequence A 1.5-T/PCASL (spin-echo) and first-pass imaging (gradient-echo). Assessment In healthy subjects, multi-delay PCASL data (500-2000 msec) were acquired to quantify splenic blood flow (SBF) and determine the adequate postlabeling delay (PLD) for single-delay acquisitions (PLD > arterial transit time). In patients, single-delay PCASL (1200 msec) and first-pass perfusion images were acquired under rest and adenosine conditions. PCASL data were used to compute SBF maps and SBF stress-to-rest ratios. Three observers classified patients into "switch-off" and "failed switch-off" groups by visually comparing rest-stress perfusion data acquired with PCASL and first-pass, independently. First-pass categories were used as reference to evaluate the accuracy of quantitative classification. Statistical Tests Wilcoxon signed-rank, Pearson correlation, kappa, percentage agreement, Generalized Linear Mixed Model, Mann-Whitney, Pearson Chi-squared, receiver operating characteristic, area-under-the-curve (AUC) and confusion matrix. Significance: P value < 0.05. Results A total of 27 patients (84.4%) experienced splenic switch-off according to first-pass categories. Comparison of PCASL-derived SBF maps during stress and rest allowed assessment of splenic switch-off, reflected in a reduction of SBF values during stress. SBF stress-to-rest ratios showed a 97% accuracy (sensitivity = 80%, specificity = 100%, AUC = 85.2%). Data Conclusion This study could demonstrate the feasibility of PCASL to identify splenic switch-off during adenosine perfusion MRI, both by qualitative and quantitative assessments. Evidence Level 2 Technical Efficacy 2
  • Autores: Lanteri, A. (Autor de correspondencia); Leorato, S.; López Fidalgo, Jesús Fernando; et al.
    Revista: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY
    ISSN: 1369-7412 Vol.85 N° 2 2023 págs. 315 - 326
    Resumen
    We consider the problem of designing experiments to detect the presence of a specified heteroscedastity in Gaussian regression models. We study the relationship of the D-s- and KL-criteria with the noncentrality parameter of the asymptotic chi-squared distribution of a likelihood-based test, for local alternatives. We found that, when the heteroscedastity depends on one parameter, the two criteria coincide asymptotically and that the D-1-criterion is proportional to the noncentrality parameter. Differently, when it depends on several parameters, the KL-optimum design converges to the design that maximizes the noncentrality parameter. Our theoretical findings are confirmed through a simulation study.
  • Autores: López Fidalgo, Jesús Fernando (Autor de correspondencia); May, A.; Moler, J. A.
    Revista: ANNALS OF APPLIED STATISTICS
    ISSN: 1932-6157 Vol.17 N° 1 2023 págs. 606 - 620
    Resumen
    Jam formation is a problem that may occur when granular material is discharged by gravity from a silo. The estimation of the minimum outlet size, which guarantees that the time to the next jamming event is long enough, can be crucial in the industry. The time is modeled by an exponential distribution with two unknown parameters, and this goal translates to precise estimation of a nonlinear transformation of the parameters. We obtain c-optimum experimental designs with that purpose, applying the graphic Elfving method. Because the optimal experimental designs depend on the nominal values of the parameters, we conduct a sensitivity analysis on our dataset. Finally, a simulation study checks the performance of the approximations, first with the Fisher Information matrix, then with the linearization of the function to be estimated. The results are useful for experimenting in a laboratory and then translating the results to a real scenario. From the application we develop a general methodology for estimating a one-dimensional transformation of the parameters of a nonlinear model.
  • Autores: Calvo Imirizaldu, Marta; Aramendia Vidaurreta, Verónica; Sánchez Albardíaz, Carmen; et al.
    Revista: NMR IN BIOMEDICINE
    ISSN: 0952-3480 Vol.36 N° 9 2023 págs. e4938
    Resumen
    Resection control in brain tumor surgery can be achieved in real time with intraoperative MRI (iMRI). Arterial spin labeling (ASL), a technique that measures cerebral blood flow (CBF) non-invasively without the use of intravenous contrast agents, can be performed intraoperatively, providing morpho-physiological information. This study aimed to evaluate the feasibility, image quality and potential to depict residual tumor of a pseudo-continuous ASL (PCASL) sequence at 3 T. Seventeen patients with brain tumors, primary (16) or metastatic (1), undergoing resection surgery with iMRI monitoring, were prospectively recruited (nine men, age 56 ± 16.6 years). A PCASL sequence with long labeling duration (3000 ms) and postlabeling delay (2000 ms) was added to the conventional protocol, which consisted of pre- and postcontrast 3D T1 -weighted (T1w) images, optional 3D-FLAIR, and diffusion. Three observers independently assessed the image quality (four-point scale) of PCASL-derived CBF maps. In those with diagnostic quality (Scores 2-4) they evaluated the presence of residual tumor using the conventional sequences first, and the CBF maps afterwards (three-point scale). Inter-observer agreement for image quality and the presence of residual tumor was assessed using Fleiss kappa statistics. The intraoperative CBF ratio of the surgical margins (i.e., perilesional CBF values normalized to contralateral gray matter CBF) was compared with preoperative CBF ratio within the tumor (Wilcoxon's test). Diagnostic ASL image quality was observed in 94.1% of patients (interobserver Fleiss ¿ = 0.76). PCASL showed additional foci suggestive of high-grade residual component in three patients, and a hyperperfused area extending outside the enhancing component in one patient. Interobserver agreement was almost perfect in the evaluation of residual tumor with the conventional sequences (Fleiss ¿ = 0.92) and substantial for PCASL (Fleiss ¿ = 0.80). No significant differences were found between pre and intraoperative CBF ratios (p = 0.578) in patients with residual tumor (n = 7). iMRI-PCASL perfusion is feasible at 3 T and is useful for the intraoperative assessment of residual tumor, providing in some cases additional information to the conventional sequences.
  • Autores: Liang, B.; Alosco, M.L.; Armañanzas Arnedillo, Ruben; et al.
    Revista: JOURNAL OF NEUROTRAUMA
    ISSN: 0897-7151 Vol.40 N° 3 - 4 2023 págs. 309 - 317
    Resumen
    Exposure to repetitive head impacts (RHI) has been associated with long-term disturbances in cognition, mood, and neurobehavioral dysregulation, and reflected in neuroimaging. Distinct patterns of changes in quantitative features of the brain electrical activity (quantitative electroencephalogram [qEEG]) have been demonstrated to be sensitive to brain changes seen in neurodegenerative disorders and in traumatic brain injuries (TBI). While these qEEG biomarkers are highly sensitive at time of injury, the long-term effects of exposure to RHI on brain electrical activity are relatively unexplored. Ten minutes of eyes closed resting EEG data were collected from a frontal and frontotemporal electrode montage (BrainScope Food and Drug Administration-cleared EEG acquisition device), as well as assessments of neuropsychiatric function and age of first exposure (AFE) to American football. A machine learning methodology was used to derive a qEEG-based algorithm to discriminate former National Football League (NFL) players (n = 87, 55.40 +/- 7.98 years old) from same-age men without history of RHI (n = 68, 54.94 +/- 7.63 years old), and a second algorithm to discriminate former players with AFE <12 years (n = 33) from AFE >= 12 years (n = 54). The algorithm separating NFL retirees from controls had a specificity = 80%, a sensitivity = 60%, and an area under curve (AUC) = 0.75. Within the NFL population, the algorithm separating AFE <12 from AFE >= 12 resulted in a sensitivity = 76%, a specificity = 52%, and an AUC = 0.72. The presence of a profile of EEG abnormalities in the NFL retirees and in those with younger AFE includes features associated with neurodegeneration and the disruption of neuronal transmission between regions. These results support the long-term consequences of RHI and the potential of EEG as a biomarker of persistent changes in brain function.
  • Autores: Echeverría-Chasco, R.; Martín Moreno, Paloma Leticia; García Fernández, Nuria (Autor de correspondencia); et al.
    Revista: NMR IN BIOMEDICINE
    ISSN: 0952-3480 Vol.36 N° 2 2023 págs. e4832
    Resumen
    Monitoring renal allograft function after transplantation is key for the early detection of allograft impairment, which in turn can contribute to preventing the loss of the allograft. Multiparametric renal MRI (mpMRI) is a promising noninvasive technique to assess and characterize renal physiopathology; however, few studies have employed mpMRI in renal allografts with stable function (maintained function over a long time period). The purposes of the current study were to evaluate the reproducibility of mpMRI in transplant patients and to characterize normal values of the measured parameters, and to estimate the labeling efficiency of Pseudo-Continuous Arterial Spin Labeling (PCASL) in the infrarenal aorta using numerical simulations considering experimental measurements of aortic blood flow profiles. The subjects were 20 transplant patients with stable kidney function, maintained over 1 year. The MRI protocol consisted of PCASL, intravoxel incoherent motion, and T1 inversion recovery. Phase contrast was used to measure aortic blood flow. Renal blood flow (RBF), diffusion coefficient (D), pseudo-diffusion coefficient (D*), flowing fraction ( f$$ f $$), and T1 maps were calculated and mean values were measured in the cortex and medulla. The labeling efficiency of PCASL was estimated from simulation of Bloch equations. Reproducibility was assessed with the within-subject coefficient of variation, intraclass correlation coefficient, and Bland-Altman analysis. Correlations were evaluated using the Pearson correlation coefficient. The significance level was p less than 0.05. Cortical reproducibility was very good for T1, D, and RBF, moderate for f$$ f $$, and low for D*, while medullary reproducibility was good for T1 and D. Significant correlations in the cortex between RBF and f$$ f $$ (r = 0.66), RBF and eGFR (r = 0.64), and D* and eGFR (r = -0.57) were found. Normal values of the measured parameters employing the mpMRI protocol in kidney transplant patients with stable function were characterized and the results showed good reproducibility of the techniques.
  • Autores: Tomás-Biosca Martín, Ana; Martínez Simón, Antonio (Autor de correspondencia); Guridi Legarra, Jorge; et al.
    Revista: JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
    ISSN: 0898-4921 Vol.35 N° 1 2023 págs. 74 - 79
    Resumen
    Background: The identification of factors associated with perioperative red blood cell (RBC) transfusion provides an opportunity to optimize the patient and surgical plan, and to guide perioperative crossmatch and RBC orders. We examined the association among potential bleeding risk factors and RBC requirements to develop a novel predictive model for RBC transfusion in patients undergoing brain tumor surgery. Methods: This retrospective study included 696 adults who underwent brain tumor surgery between 2008 and 2018. Multivariable logistic regression with backward stepwise selection for predictor selection was used during modeling. Model performance was evaluated using area under the receiver operating characteristic curve, and calibration was evaluated with Hosmer-Lemeshow goodness-of-fit ¿2-estimate. Results: Preoperative hemoglobin level was inversely associated with the probability of RBC transfusion (odds ratio [OR]: 0.50; 95% confidence interval [CI]: 0.39-0.63; P<0.001). The need for RBC transfusion was also greater in patients who had a previous craniotomy (OR: 2.71; 95% CI: 1.32-5.57; P=0.007) and in those with larger brain tumor volume (OR: 1.01; 95% CI: 1.00-1.02; P=0.009). The relationship between number of planned craniotomy sites and RBC transfusion was not statistically significant (OR: 2.11; 95% CI: 0.61-7.32; P=0.238). A predictive model for RBC requirements was built using these 4 variables. The area under the receiver operating characteristic curve was 0.79 (95% CI: 0.70-0.87; P<0.001) showing acceptable calibration for predicting RBC transfusion requirements. Conclusions: RBC requirements in patients undergoing brain tumor surgery can be estimated with acceptable accuracy using a predictive model based on readily available preoperative clinical variables. This predictive model could help to optimize both individual patients and surgical plans, and to guide perioperative crossmatch orders.
  • Autores: de la Calle-Arroyo, C.; Amo-Salas, M.; López Fidalgo, Jesús Fernando; et al.
    Revista: CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
    ISSN: 0169-7439 Vol.237 2023 págs. 104822
    Resumen
    One of the main criticisms of optimal experimental designs is that they tend not to adequately meet the practical needs of the experimenter. For example, optimal designs for estimation of the parameters in a model frequently have too few designs points to check the model adequacy, to discriminate between rival models or to estimate a particular function of the parameters. Further, some experimenters like toxicologists have been schooled to using many doses in an animal experiment and there is great resistance to using a design with just a few doses. This paper uses the General Equivalence Theorem to define regions where the practitioner may select points flexibly to augment a design that meets the practical needs more adequately and has a user-specified minimum efficiency requirement. As examples, we demonstrate the usefulness of our theory-based method in various setups using statistical models, such as Antoine's Equation, the Michaelis-Menten model and a quadratic heteroscedastic model. We also explore the power of the lack-of-fit test for several D-augmented designs in a simulation study. We provide user-friendly codes, either through the R package optedr or through a graphical user interface in Shiny, to facilitate practitioners implement our methodology to find an improved D-augmented designs for their problems.
  • Autores: Culebras Díaz, A. M.; Gordo Luis, Cristina; Mateo Dueñas, Ricardo; et al.
    Revista: SURGERY TODAY
    ISSN: 0941-1291 Vol.53 N° 2 2023 págs. 269 - 273
    Resumen
    Wrong surgery (wrong-site, wrong-procedure, or wrong-patient surgery) is among the most feared patient safety problems in hospitals. We aimed to evaluate associations between numeric assessment of risk assigned to wrong surgery with that of other healthcare quality and patient safety challenges. This nationwide study collected information from healthcare quality experts in charge of a clinical quality and/or patient safety department in general hospitals of >= 150 beds in Spain. Out of the 100 included hospitals, the highest strength of associations were observed with risk priority number (RPN) for hospital-acquired pressure ulcers, RPN for venous thromboembolism in hospitalized patients, RPN for incorrect patient identification, RPN for lack of informed consent for diagnostic or therapeutic procedures, RPN for catheter-related bacteremia, and RPN for adverse events and injuries due to medical devices related to use and/or design. These results are of potential interest for designing combined and coordinated strategies to improve patient safety in hospitals.
  • Autores: Hernández-García, L. (Autor de correspondencia); Aramendia Vidaurreta, Verónica; Bolar, D. S.; et al.
    Revista: MAGNETIC RESONANCE IN MEDICINE
    ISSN: 0740-3194 Vol.88 N° 5 2022 págs. 2021 - 2042
    Resumen
    This review article provides an overview of a range of recent technical developments in advanced arterial spin labeling (ASL) methods that have been developed or adopted by the community since the publication of a previous ASL consensus paper by Alsop et al. It is part of a series of review/recommendation papers from the International Society for Magnetic Resonance in Medicine Perfusion Study Group. Here, we focus on advancements in readouts and trajectories, image reconstruction, noise reduction, partial volume correction, quantification of nonperfusion parameters, fMRI, fingerprinting, vessel selective ASL, angiography, deep learning, and ultrahigh field ASL. We aim to provide a high level of understanding of these new approaches and some guidance for their implementation, with the goal of facilitating the adoption of such advances by research groups and by MRI vendors. Topics outside the scope of this article that are reviewed at length in separate articles include velocity selective ASL, multiple-timepoint ASL, body ASL, and clinical ASL recommendations.
  • Autores: Martínez Simón, Antonio; Honorato Cia, María Cristina; Cacho Asenjo, Elena; et al.
    Revista: BRITISH JOURNAL OF ANAESTHESIA
    ISSN: 0007-0912 Vol.128 N° 3 2022 págs. E239 - E241
  • Autores: Viles Díez, Elisabeth; Kalemkerian, Florencia; Garza-Reyes, Jose Arturo ; et al.
    Revista: SUSTAINABLE PRODUCTION AND CONSUMPTION
    ISSN: 2352-5509 Vol.33 2022 págs. 1043 - 1058
    Resumen
    The concept of Sustainable Production is evolving with changes triggered by the emergence of new economic and industrial models such as Circular Economy and Industry 4.0. However, most studies that currently link these concepts are based on the principles of Sustainable Production defined 20 years ago. Therefore, the primary aim of this study is to redefine the principles that should govern Sustainable Production operations in the tran-sition towards a Circular Economy and smart industry models. To this end, an initial proposal of 11 principles was shared with 11 world-class experts (academics and practitioners) and a consensus proposal was sought through a Delphi Panel. Ten principles emerged from this study, which were evaluated by experts according to criteria of significance, parsimony, semantic consistency and empirical adequacy. Additionally, to study the rela-tionships between the ten principles, the Interpretative Structural Model (ISM) technique was applied. The ISM technique identified which principles are independent of or dependent on each other and established relation-ships between the principles. The findings suggest that Principle 5 ("Prioritize employees' well-being"), Principle 6 ("Enhance management commitment to sustainability"), Principle 9 ("Measure and optimize sustainable pro-cesses") and Principle 10 ("Boost the use of sustainable technologies") help to establish an ideal context to enhance the development of the rest of the principles that characterize Sustainable Production. The presentation of the ten principles opens new possibilities for researchers while helping managers to better understand sustainability in terms of production and, therefore contribute to achieving SDG 12.
  • Autores: Boer, A.; Villa, G.; Bane, O. ; et al.
    Revista: JOURNAL OF MAGNETIC RESONANCE IMAGING
    ISSN: 1053-1807 Vol.55 N° 2 2022 págs. 323 - 335
    Resumen
    Background Phase-contrast (PC) MRI is a feasible and valid noninvasive technique to measure renal artery blood flow, showing potential to support diagnosis and monitoring of renal diseases. However, the variability in measured renal blood flow values across studies is large, most likely due to differences in PC-MRI acquisition and processing. Standardized acquisition and processing protocols are therefore needed to minimize this variability and maximize the potential of renal PC-MRI as a clinically useful tool. Purpose To build technical recommendations for the acquisition, processing, and analysis of renal 2D PC-MRI data in human subjects to promote standardization of renal blood flow measurements and facilitate the comparability of results across scanners and in multicenter clinical studies. Study Type Systematic consensus process using a modified Delphi method. Population Not applicable. Sequence Field/Strength Renal fast gradient echo-based 2D PC-MRI. Assessment An international panel of 27 experts from Europe, the USA, Australia, and Japan with 6 (interquartile range 4-10) years of experience in 2D PC-MRI formulated consensus statements on renal 2D PC-MRI in two rounds of surveys. Starting from a recently published systematic review article, literature-based and data-driven statements regarding patient preparation, hardware, acquisition protocol, analysis steps, and data reporting were formulated. Statistical Tests Consensus was defined as >= 75% unanimity in response, a
  • Autores: López Fidalgo, Jesús Fernando (Autor de correspondencia); Martin-Martin, R.; Rodriguez-Hernandez, M.
    Revista: COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
    ISSN: 0361-0918 Vol.51 N° 4 2022 págs. 1488 - 1502
    Resumen
    Models of mixture distributions are of great interest in many areas where several populations are mixed up. If the response is binary there is a mixture of Bernoulli distributions, which has practical applications for the classification of texts and images, biochemistry, genetics, robotics, computer science or pattern recognition. A finite mixture of probability distributions includes a set of parameters such as the proportion of the mixture and the parameters of each distribution. This simple case allows us to make some explicit computations of the estimators as well as working on the EM algorithm doing some comparisons. Some of these parameters may depend on one or more covariates through some specific model. Mixtures of exponential family distributions, except in very particular cases, are no longer within the exponential family and this means, among other things, that the expectation for computing the Information Matrix must, in most cases, be approximated. One of the main contributions of this article is its handling of this. Linear and logistic models are considered either for the proportion of one of the two populations (clusters), or for the parameters of the Bernoulli distributions. For each of these cases the analytic expression of the information matrix is calculated and optimal designs determined.
  • Autores: Nikiforova, N. D. (Autor de correspondencia); Berni, R.; López Fidalgo, Jesús Fernando
    Revista: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS
    ISSN: 0035-9254 Vol.71 N° 5 2022 págs. 1895 - 1917
    Resumen
    This work deals with consumers' preferences about coffee. Firstly, a choice experiment is performed on a sample of potential consumers. Following this, a sensory test involving the tasting of two varieties of coffee is carried out with the respondents, after which the same choice experiment is supplied to them again. An innovative approach for building heterogeneous choice designs is specifically developed for the case-study, based on approximate design theory and compound design criterion. Panel Mixed Logit models are used, thereby allowing for the inclusion of correlation among consumers' responses; choice-sets are supplied to a proportion of respondents according to optimal weights. The estimation results of the Panel Mixed Logit model are satisfactory, confirming the validity of the proposed approach.
  • Autores: Aramendia Vidaurreta, Verónica; Gordaliza, P. M.; Vidorreta, M.; et al.
    Revista: MAGNETIC RESONANCE IN MEDICINE
    ISSN: 0740-3194 Vol.87 N° 3 2022 págs. 1261 - 1275
    Resumen
    Purpose To evaluate the accuracy and reproducibility of myocardial blood flow measurements obtained under different breathing strategies and motion correction techniques with arterial spin labeling. Methods A prospective cardiac arterial spin labeling study was performed in 12 volunteers at 3 Tesla. Perfusion images were acquired twice under breath-hold, synchronized-breathing, and free-breathing. Motion detection based on the temporal intensity variation of a myocardial voxel, as well as image registration based on pairwise and groupwise approaches, were applied and evaluated in synthetic and in vivo data. A region of interest was drawn over the mean perfusion-weighted image for quantification. Original breath-hold datasets, analyzed with individual regions of interest for each perfusion-weighted image, were considered as reference values. Results Perfusion measurements in the reference breath-hold datasets were in line with those reported in literature. In original datasets, prior to motion correction, myocardial blood flow quantification was significantly overestimated due to contamination of the myocardial perfusion with the high intensity signal of blood pool. These effects were minimized with motion detection or registration. Synthetic data showed that accuracy of the perfusion measurements was higher with the use of registration, in particular after the pairwise approach, which probed to be more robust to motion. Conclusion Satisfactory results were obtained for the free-breathing strategy after pairwise registration, with higher accuracy and robustness (in synthetic datasets) and higher intrasession reproducibility together with lower myocardial blood flow variability across subjects (in in vivo datasets). Breath-hold and synchronized-breathing after motion correction provided similar results, but these breathing strategies can be difficult to perform by patients.
  • Autores: Casero-Alonso, V. (Autor de correspondencia); López Fidalgo, Jesús Fernando; Wong, W. K.
    Revista: STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT
    ISSN: 1436-3240 Vol.36 2022 págs. 2695 - 2710
    Resumen
    Fractional polynomials (FP) have been shown to be more flexible than polynomial models for fitting data from an univariate regression model with a continuous outcome but design issues for FP models have lagged. We focus on FPs with a single variable and construct D-optimal designs for estimating model parameters and I-optimal designs for prediction over a user-specified region of the design space. Some analytic results are given, along with a discussion on model uncertainty. In addition, we provide an applet to facilitate users find tailor made optimal designs for their problems. As applications, we construct optimal designs for three studies that used FPs to model risk assessments of (a) testosterone levels from magnesium accumulation in certain areas of the brains in songbirds, (b) rats subject to exposure of different chemicals, and (c) hormetic effects due to small toxic exposure. In each case, we elaborate the benefits of having an optimal design in terms of cost and quality of the statistical inference.
  • Autores: García Manglano, Javier (Autor de correspondencia); Lopez Madrigal, Claudia; Sádaba Chalezquer, Charo; et al.
    Revista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
    ISSN: 1660-4601 Vol.19 N° 1 2022 págs. 358
    Resumen
    The smartphone revolution has placed powerful, multipurpose devices in the hands of youth across the globe, prompting worries about the potential negative consequences of these technologies on mental health. Many assessment tools have been created, seeking to classify individuals into problematic and non-problematic smartphone users. These are identified using a cutoff value: a threshold, within the scale range, at which higher scores are expected to be associated with negative outcomes. Lacking a clinical assessment of individuals, the establishment of this threshold is challenging. We illustrate this difficulty by calculating cutoff values for the Short Version of the Smartphone Addiction Scale (SAS-SV) in 13 Spanish-speaking samples in 11 countries, using common procedures (i.e., reliability, validity, ROC methodology). After showing that results can be very heterogeneous (i.e., they lead to diverse cutoff points and rates of addiction) depending on the decisions made by the researchers, we call for caution in the use of these classifications, particularly when researchers lack a clinical definition of true addiction-as is the case with most available scales in the field of behavioral addictions-which can cause an unnecessary public health alert.
  • Autores: López Fidalgo, Jesús Fernando (Autor de correspondencia); Wiens, D. P.
    Revista: JOURNAL OF STATISTICAL PLANNING AND INFERENCE
    ISSN: 0378-3758 Vol.220 2022 págs. 1 - 14
    Resumen
    We introduce a method of Robust Learning ('robl') for binary data, and propose its use in situations where Active Learning is appropriate, and where sampling the predictors is easy and cheap, but learning the responses is hard and expensive. We seek robustness against both modelling errors and the mislabelling of the binary responses. Thus we aim to sample effectively from the population of predictors, and learn the responses only for an 'influential' sub-population. This is carried out by probability weighted sampling, for which we derive optimal 'unbiased' sampling weights, and weighted likelihood estimation, for which we also derive optimal estimation weights. The robustness issues can lead to biased estimates and classifiers; it is somewhat remarkable that our weights eliminate the mean of the bias - which is a random variable as a result of the sampling - due to both types of errors mentioned above. These weights are then tailored to minimize the mean squared error of the predicted values. Simulation studies indicate that when bias is of significant concern, robl allows for substantial reductions, relative to Passive Learning, in the prediction errors. The methods are then illustrated in real-data analyses. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • Autores: Mora Gutiérrez, Jose María; Fernández Seara, María Asunción (Autor de correspondencia); Echeverria Chasco, R.; et al.
    Revista: JOURNAL OF CLINICAL MEDICINE
    ISSN: 2077-0383 Vol.10 N° 11 2021 págs. 2461
    Resumen
    Renal magnetic resonance imaging (MRI) techniques are currently in vogue, as they provide in vivo information on renal volume, function, metabolism, perfusion, oxygenation, and microstructural alterations, without the need for exogenous contrast media. New imaging biomarkers can be identified using these tools, which represent a major advance in the understanding and study of the different pathologies affecting the kidney. Diabetic kidney disease (DKD) is one of the most important diseases worldwide due to its high prevalence and impact on public health. However, its multifactorial etiology poses a challenge for both basic and clinical research. Therefore, the use of novel renal MRI techniques is an attractive step forward in the comprehension of DKD, both in its pathogenesis and in its detection and surveillance in the clinical practice. This review article outlines the most promising MRI techniques in the study of DKD, with the purpose of stimulating their clinical translation as possible tools for the diagnosis, follow-up, and monitoring of the clinical impacts of new DKD treatments.
  • Autores: Ferrando, C. (Autor de correspondencia); Suarez-Sipmann, F.; Mellado-Artigas, R.; et al.
    Revista: INTENSIVE CARE MEDICINE
    ISSN: 0342-4642 Vol.47 N° 1 2021 págs. 144 - 146
    Resumen
    The original version of this article unfortunately contained mistakes in Figures 1 and 3.
  • Autores: Berni, R.; López Fidalgo, Jesús Fernando; Vining, G. G.
    Revista: APPLIED STOCHASTIC MODELS IN BUSINESS AND INDUSTRY
    ISSN: 1524-1904 Vol.37 N° 5 (Special Issue: Statistics, Statistical Engineering, and Innovation for Industry 4.0)) 2021 págs. 837 - 838
  • Autores: Hidalgo-Andrade, P.; Paz, C. (Autor de correspondencia); Hermosa-Bosano, C.; et al.
    Revista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
    ISSN: 1661-7827 Vol.18 N° 21 2021 págs. 11104
    Resumen
    The COVID-19 pandemic has affected the lives of millions of people worldwide. This study aimed to analyze the effects of several psychological factors (self-esteem, self-control, and emotional stability) over lifestyle-related variables (time spent on leisure activities) and the levels of satisfaction (family, friends, work, and leisure satisfaction) experienced during the COVID-19 outbreak. Data for this article were retrieved as part of a cross-sectional international study conducted in eleven Spanish-speaking countries between March and September 2020. The analyses were conducted using the responses of 9500 persons (65.95% women, 34.05% men). Structural equation modeling was used to test the direct and indirect effects of the psychological variables on satisfaction variables mediated by the time engaged in leisure activities. Our model indicated that psychological factors significantly predicted the amount of time spent in leisure activities and satisfaction. Overall, results indicate that self-esteem is a relevant psychological factor to consider in the development of psychological interventions directed at promoting healthy lifestyles. Nevertheless, further research is needed to validate the direction of the associations found in this study.
  • Autores: Solis-Barquero, S.; Echeverria-Chasco, R.; Calvo Imirizaldu, Marta; et al.
    Revista: FRONTIERS IN PHYSIOLOGY
    ISSN: 1664-042X Vol.12 2021 págs. 621720
    Resumen
    A pseudocontinuous arterial spin labeling (PCASL) sequence combined with background suppression and single-shot accelerated 3D RARE stack-of-spirals was used to evaluate cerebrovascular reactivity (CVR) induced by breath-holding (BH) in ten healthy volunteers. Four different models designed using the measured change in PETCO2 induced by BH were compared, for CVR quantification. The objective of this comparison was to understand which regressor offered a better physiological model to characterize the cerebral blood flow response under BH. The BH task started with free breathing of 42 s, followed by interleaved end-expiration BHs of 21 s, for ten cycles. The total scan time was 12 min and 20 s. The accelerated readout allowed the acquisition of PCASL data with better temporal resolution than previously used, without compromising the post-labeling delay. Elevated CBF was observed in most cerebral regions under hypercapnia, which was delayed with respect to the BH challenge. Significant statistical differences in CVR were obtained between the different models in GM (p < 0.0001), with ramp models yielding higher values than boxcar models and between the two tissues, GM and WM, with higher values in GM, in all the models (p < 0.0001). The adjustment of the ramp amplitude during each BH cycle did not improve the results compared with a ramp model with a constant amplitude equal to the mean PETCO2 change during the experiment.
  • Autores: Echeverria-Chasco, R.; Vidorreta, M.; Aramendia Vidaurreta, Verónica; et al.
    Revista: MAGNETIC RESONANCE IN MEDICINE
    ISSN: 0740-3194 Vol.85 N° 3 2021 págs. 1507 - 1521
    Resumen
    Purpose To evaluate labeling efficiency of pseudo-continuous arterial spin labeling (PCASL) and to find the gradient parameters that increase PCASL robustness for renal perfusion measurements. Methods Aortic blood flow was characterized in 3 groups: young healthy volunteers (YHV1), chronic kidney disease (CKD) patients (CKDP), and healthy controls (HCO). PCASL inversion efficiency was evaluated through numeric simulations considering the measured pulsatile flow velocity profiles and off-resonance effects for a wide range of gradient parameters, and the results were assessed in vivo. The most robust PCASL implementation was used to measure renal blood flow (RBF) in CKDP and HCO. Results Aortic blood velocities reached peak values of 120 cm/s in YHV1, whereas for elderly subjects values were lower by approximately a factor of 2. Simulations and experiments showed that by reducing the gradient average (G(ave)) and the selective to average gradient ratio (G(max)/G(ave)), labeling efficiency was maximized and PCASL robustness to off-resonance was improved. The study in CKDP and HCO showed significant differences in RBF between groups. Conclusion An efficient and robust PCASL scheme for renal applications requires aG(max)/G(ave)ratio of 6-7 and aG(ave)value that depends on the aortic blood flow velocities (0.5 mT/m being appropriate for CKDP and HCO).
  • Autores: Aramendia Vidaurreta, Verónica; Echeverria-Chasco, R. ; Vidorreta, M. ; et al.
    Revista: JOURNAL OF MAGNETIC RESONANCE IMAGING
    ISSN: 1053-1807 Vol.53 N° 3 2021 págs. 777 - 788
    Resumen
    Background Myocardial perfusion is evaluated in first-pass MRI using a gadolinium-based contrast agent, which limits its repeatability and restricts its use in patients with abnormal kidney function. Arterial spin labeling (ASL) is a promising technique for measuring myocardial perfusion without contrast injection. The ratio of stress to rest perfusion, termed myocardial perfusion reserve (MPR), is an indicator of the severity of stenosis in patients with coronary artery disease (CAD). Purpose To quantify perfusion increases with pharmacological vasodilation, explore MPR differences between segments with and without perfusion defects, and examine the correlations between quantitative ASL and semiquantitative first-pass measurements. Study Type Prospective. Subjects Sixteen patients with suspected CAD: 10 classified as "healthy," having normal perfusion on first-pass and no enhancement on late gadolinium enhancement (LGE), and six as "nonhealthy," having hypoperfused segments including ischemic and infarcted. Field Strength/Sequence Flow-sensitive alternating inversion recovery (FAIR) rest-stress cardiac ASL with balanced steady-state free precession (bSSFP), rest-stress first-pass imaging using gradient-echo and LGE using a phase-sensitive inversion-recovery bSSFP at 1.5T. Assessment For healthy subjects, rest-stress perfusion data were compared in global, coronary artery territory, and segment regions of interest (ROIs). A segmental MPR comparison was performed between normal segments from healthy subjects and abnormal segments from nonhealthy subjects. Correlations between ASL and first-pass parameters were explored. Statistical Tests Wilcoxon-signed-rank test, nonparametric factorial analysis of variance (ANOVA), and Pearson's/Spearman's correlations. Results Perfusion increases were significant globally (P= 0.005), per coronary artery territory (P= 0.015), and per segment (P= 0.03 for all segments in ASL and first-pass, except anteroseptal in ASLP= 0.04). MPR differences between normal and abnormal segments were significant (P= 0.0028: ASL,P= 0.033: first-pass). ASL and first-pass measurements were correlated (MPR:r =0.64,P= 0.008 and perfusion:rho= 0.47,P= 0.007). Data Conclusion This study demonstrates the feasibility of ASL to detect hyperemia, the potential to differentiate segments with and without perfusion defects, and significant correlations between ASL and semiquantitative first-pass. Level of Evidence 2 Technical Efficacy Stage 1
  • Autores: Azurmendi Adarraga, Ana (Autor de correspondencia); Etayo Pérez, Cristina; Torrell, A.
    Revista: PROFESIONAL DE LA INFORMACION
    ISSN: 1386-6710 Vol.30 N° 4 2021 págs. e300407
    Resumen
    Sharenting -dissemination on social networks of images and comments about children, minors, by their parents-, is a growing phenomenon (Kopecky et al., 2020; Bessant, 2018). The Covid-19 pandemic has increased the use of social networks, especially during the months of confinement. Social networks have helped to alleviate the separation, and to the extent that communication with family and friends has been frequent, they have also contributed to an increase in sharenting (Saud; Mashud; Ida, 2020). It is still unknown if this phenomenon is specific or if, on the contrary, confinement has contributed to changing social attitudes towards this parental activity (Bessant; Nottingham; Oswald, 2020). In any case, the need to reflect on the consequences and on the rights that come into play in sharenting has become evident. The research presented studies sharenting from the right to freedom of expression of parents, and the rights to private life of children under their guardianship and their digital identity; also from the perspective of the minor's vision of this parental activity. A review of the bibliography shows the variety of arguments that have expressed the modalities of balance between these rights present in sharenting. The research is completed with a survey of children and adolescents between 13 and 18 years old, carried out in March 2020. This is how we respond to the criticism of the studies on the rights of minors for not including their own vision (Cowden, 2016).
  • Autores: Montoro Gurich, Carolina; Pons Izquierdo, Juan José
    Revista: BOLETIN DE LA ASOCIACION DE GEOGRAFOS ESPAÑOLES
    ISSN: 0212-9426 N° 90 2021
    Resumen
    Este trabajo analiza y representa cartográficamente en cuatro momentos temporales (2002, 2007, 2012 y 2017) el envejecimiento de las áreas urbanas españolas y su relación con el envejecimiento de la provincia en la que están situadas. También se definen cuatro modelos de envejecimiento según la relación entre la intensidad del envejecimiento en 2020 y la tasa de variación del período completo. La Estadística del Padrón Continuo se emplea para el cálculo del porcentaje de población de 65 y más años ¿indicador de envejecimiento¿ y el de 80 y más años ¿de sobrenvejecimiento¿. La delimitación del espacio urbano elegida es la del Atlas Estadístico de las Áreas Urbanas en España. Como principales conclusiones, (1) se han reducido los contrastes del envejecimiento entre el mundo urbano y el mundo rural, mientras que han aumentado los del sobrenvejecimiento a favor del mundo rural; (2) los contrastes más acusados los encontramos entre la mayoría de las áreas urbanas del noroeste español, con niveles altos y ritmo rápido de envejecimiento, frente a las áreas urbanas del litoral mediterráneo y andaluz, con niveles y ritmos más lentos de envejecimiento.
  • Autores: Íñigo Marco, Ignacio; Isturiz, J.; Fernández, M.; et al.
    Revista: ANNALS OF BIOMEDICAL ENGINEERING
    ISSN: 0090-6964 Vol.49 N° 2 2021 págs. 746 - 756
    Resumen
    Imaging of small laboratory animals in clinical MRI scanners is feasible but challenging. Compared with dedicated preclinical systems, clinical scanners have relatively low B(0)field (1.5-3.0 T) and gradient strength (40-60 mT/m). This work explored the use of wireless inductively coupled coils (ICCs) combined with appropriate pulse sequence parameters to overcome these two drawbacks, with a special emphasis on the optimization of the coil passive detuning circuit for this application. A Bengal rose photothrombotic stroke model was used to induce cortical infarction in rats and mice. Animals were imaged in a 3T scanner using T2 and T1-weighted sequences. In all animals, the ICCs allowed acquisition of high-quality images of the infarcted brain at acute and chronic stages. Images obtained with the ICCs showed a substantial increase in SNR compared to clinical coils (by factors of 6 in the rat brain and 16-17 in the mouse brain), and the absence of wires made the animal preparation workflow straightforward.
  • Autores: Gordo Luis, Cristina; Mateo Dueñas, Ricardo; Labiano Turrillas, Juana María; et al.
    Revista: JOURNAL OF PATIENT SAFETY
    ISSN: 1549-8417 Vol.17 N° 8 2021 págs. 541 - 547
    Resumen
    Objective The aim of the study was to identify and rank leading healthcare quality and patient safety challenges of general hospitals in Spain. Methods A novel online cross-sectional survey for hospitals with 150 or more beds carried out between June and September 2018. Sample frame is hospitals of the National Catalogue of Hospitals of the Ministry of Health in Spain (N = 888). Eligibility criteria are quality experts of clinical quality and/or patient safety services of general hospitals with 150 or more beds. Challenges were ranked using a risk priority number (RPN) calculated from the product of severity, frequency, and detectability scores. Results Targeted hospitals were 234. The contact rate was 97.4%, representing 63% of total beds nationwide. One hundred hospitals completed the questionnaire. According to the RPN, the top five challenges were incorrect hand hygiene of health professionals (mean RPN = 334.5, SD = 198.5), ineffective interprofessional communication (mean RPN = 334.3, SD = 169.5), medication errors in transitions of care (mean RPN = 254.0, SD = 151.0), low reporting rates of patient safety incidents and adverse events (mean RPN = 252.3, SD = 176.3), and antimicrobial resistance due to inappropriate use of antibiotics (mean RPN = 243.5, SD = 158.7). Conclusions This pioneer study of ranking quality and patient safety challenges of hospitals in Spain provides an evidence-based and context-specific foundation for quality improvement decision-making.
  • Autores: Ku, M. C.; Fernández Seara, María Asunción (Autor de correspondencia); Kober, F.; et al.
    Revista: METHODS IN MOLECULAR BIOLOGY
    ISSN: 1064-3745 Vol.2216 2021 págs. 229 - 239
    Resumen
    The kidney is a complex organ involved in the excretion of metabolic products as well as the regulation of body fluids, osmolarity, and homeostatic status. These functions are influenced in large part by alterations in the regional distribution of blood flow between the renal cortex and medulla. Renal perfusion is therefore a key determinant of glomerular filtration. Therefore the quantification of regional renal perfusion could provide important insights into renal function and renal (patho)physiology. Arterial spin labeling (ASL) based perfusion MRI techniques, can offer a noninvasive and reproducible way of measuring renal perfusion in animal models. This chapter addresses the basic concept of ASL-MRI. This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.
  • Autores: Aguilar, C.; Serna-Jiménez, J.; Benítez Sastoque, Edgar Ricardo; et al.
    Revista: ULTRASONICS SONOCHEMISTRY
    ISSN: 1350-4177 Vol.72 2021 págs. 105415
    Resumen
    Raw meat emulsions may have natural, spoilage and pathogenic microorganisms due to the origin and characteristics of this food matrix. All of these microorganisms must be minimized during industrial processing to make food consumption safe and meet quality regulations. Therefore, in this research, the effect of probe ultrasound on the inactivation of three kinds of microorganisms in a raw meat emulsion is evaluated. The microorganisms are: natural microflora NAM, Listeria monocytogenes LIS, and Lactobacillus delbrueckii LAC. A high-intensity probe ultrasound system was used, during 1.0, 2.5, 5.0, 7.5 and 10 min, with pulsed waves of 0.0, 10, 20 and 30 seg, and 200, 250, 300, 350 and 400 W of power. The interrelation between time, wave pulse cycle, and power factors was assessed. The results showed a positive linear independence effect in the treatments without wave pulse for each microorganism, and a quadratic interaction with the time and the ultrasound power for the inactivation of the three kinds of microorganisms. Besides, the desirability function for the inactivation reached up to 60% of the microbial population with the probe ultrasound treatment, with 10 min, a 7.56 s wave pulse and 400 W of power. Thus, these results could be useful to decide the incorporation of mild and emerging technologies in a meat industry line process.
  • Autores: De La Calle-Arroyo, C.; López Fidalgo, Jesús Fernando; Rodríguez-Aragón, L. J.
    Revista: CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
    ISSN: 0169-7439 Vol.214 2021
    Resumen
    Vapor pressure is a temperature-dependent characteristic of pure liquids, and also of their mixtures. This thermodynamic property can be characterized through a wide range of models. Antoine Equation stands out among them for its simplicity and precision. Its parameters are estimated via maximum likelihood with experimental data. Once the parameters of the equation have been estimated, vapor pressures between known values of the curve can be interpolated. Other physical properties such as heat of vaporization can be predicted as well. This paper presents optimal designs to estimate the unknown parameters of the Antoine Equation as accurately as possible, considering a normal homoscedastic and heteroscedastic variance for the response. The aim is to improve the precision of inferences using optimality criteria to address different questions, such as fitting the whole model, focusing on some parameters of interest, or making predictions in a specific part of the space. In particular, the experimenter may choose between minimizing: the confidence region of the parameters, the variance of a subset of the parameters, the average of the variance of the parameters, or the variances of the predictions in a defined region. Optimal designs are often criticized by experimenters for their small number of experimental points. However, once the optimal designs are known, and given the idea of efficiency of a design, some strategies are presented here to improve their usual experimental designs. This study is complemented by an online tool that allows the user to replicate the calculations presented and extend them to any substance and temperature range.
  • Autores: Flor Peris, Maria Luisa; Oltra Mestre, Maria José; Sanjurjo San Martín, Elena
    Revista: IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT
    ISSN: 0018-9391 Vol.68 N° 3 2021 págs. 853 - 867
    Resumen
    Open innovation (OI) has been mainly associated with high-technology firms. This paper aims to analyze how firms in low and medium technology industries implement their OI strategy. In doing so, we explore common patterns in OI strategies by considering inbound, outbound, and coupled OI practices. We also examine whether there are differences in innovation performance among companies adopting a specific OI strategy. The study is carried out on a sample of 242 Spanish innovating companies. Based on the relevance of the different OI practices, we identify three types of OI firms: advanced open innovators, intermediate open innovators, and incipient open innovators. Our results reveal that advanced open innovators have a higher performance in product innovation, and that there are no differences among groups in process and organizational innovation.
  • Autores: Miranda Galcerán, Montserrat Ana (Autor de correspondencia); Álvarez Sánchez-Arjona, María Jesús; Briand, C.; et al.
    Revista: JOURNAL OF MODELLING IN MANAGEMENT
    ISSN: 1746-5664 Vol.16 N° 2 2021 págs. 464 - 485
    Resumen
    Purpose This study aims to reduce carbon emissions and costs in an automobile production plant by improving the operational management efficiency of a serial assembly line assisted by a feeding electric tow vehicle (ETV). Design/methodology/approach A multi-objective function is formulated to minimize the energy consumption of the ETV from which emissions and costs are measured. First, a mixed-integer linear programming model is used to solve the feeding problem for different sizes of the assembly line. Second, a bi-objective optimization (HBOO) model is used to simultaneously minimize the most eco-efficient objectives: the number of completed runs (tours) by the ETV along the assembly line, and the number of visits (stops) made by the ETV to deliver kits of components to workstations. Findings The most eco-efficient strategy is always the bi-objective optimal solution regardless of the size of the assembly line, whereas, for single objectives, the optimization strategy differs depending on the size of the assembly line. Research limitations/implications Instances of the problem are randomly generated to reproduce real conditions of a particular automotive factory according to a previous case study. The optimization procedure allows managers to assess real scenarios improving the assembly line eco-efficiency. These results promote the implementation of automated control of feeding processes in green manufacturing. Originality/value The HBOO-model assesses the assembly line performance with a view to reducing the environmental impact effectively and contributes to reducing the existent gap in the literature. The optimization results define key strategies for manufacturing industries eager to integrate battery-operated motors or to address inefficient traffic of automated transport to curb the carbon footprint.
  • Autores: Hermosa-Bosano, C.; Paz, C. (Autor de correspondencia); Hidalgo-Andrade, P.; et al.
    Revista: REVISTA ECUATORIANA DE NEUROLOGIA
    ISSN: 1019-8113 Vol.30 N° 2 2021 págs. 40 - 47
    Resumen
    Objetivo: Describir el estado de la salud mental de los adultos ecuatorianos durante la pandemia por COVID-19 de marzo a agosto de 2020. Para este fin, se analizaron los datos de un estudio más amplio que involucró varios países hispanohablantes. La investigación tuvo un diseño no experimental, cuantitativo, transversal de tipo descriptivo donde se aplicó una encuesta anónima en línea. Resultados: En total participaron 766 personas, 64.23% fueron mujeres y la edad media fue de 32.35 (DT = 12.54). Alrededor del 8% de los participantes declararon haber tenido diagnóstico de COVID-19 y un 12.9% haber experimentado síntomas relacionados. La mayor parte de los participantes (77.4%) indicaron no haber tenido problemas de salud mental en el pasado y el 87.6% no tener estos problemas durante la pandemia. Sin embargo, el 41% reconoció tener mayor malestar psicológico. Los participantes presentaron niveles bajos de síntomas (depresión, ansiedad y estrés). Las mujeres y los adultos jóvenes fueron los grupos más afectados por los síntomas evaluados. Conclusiones: En situaciones de confinamiento y pandemia es necesaria la atención de la salud mental de la población general y, en especial, la de las mujeres y los adultos jóvenes.
  • Autores: Montoro Gurich, Carolina (Autor de correspondencia); Moreno Tapia, Camila Isabel
    Revista: CIUDAD Y TERRITORIO. ESTUDIOS TERRITORIALES
    ISSN: 1133-4762 Vol.53 N° 209 2021 págs. 701 - 720
    Resumen
    El paradigma del envejecimiento activo reivindica la atención a una creciente población longeva. A colación del mismo, el movimiento de las "ciudades amigables con los mayores" busca optimizar el uso de los espacios urbanos para mejorar la calidad de vida según se envejece. Este trabajo tiene como objetivo analizar el impacto de las infraestructuras de movilidad vertical en la calidad de vida de las personas mayores que residen en barrios con desniveles topográficos. La metodología es cualitativa y consiste en un estudio de caso de la ciudad de Pamplona (España). Los datos se han obtenido a través de entrevistas en profundidad y grupos focales. Los resultados principales son que las IMUV mejoran la accesibilidad de personas con movilidad reducida, potencian la permeabilidad urbana y, generan cambios positivos en el tejido y los usos urbanos.
  • Autores: Higueras, M. (Autor de correspondencia); Howes, A. ; López Fidalgo, Jesús Fernando
    Revista: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
    ISSN: 0955-3002 Vol.96 N° 7 2020 págs. 894 - 902
    Resumen
    Purpose:To introduce optimal experimental design techniques in the cytogenetic biological dosimetry practice. This includes the development of a new optimality criterion for the calibration of radiation doses. Materials and methods:The most typical optimal design criterion and the one developed in this research are introduced and applied in an example from the literature. In another example from the literature, a simulation study has been performed to compare the standard error of the dose estimation using different experimental designs. An RStudio project and a GitHub project have been developed to reproduce these results. Results:In the paper, it is observed that the application of optimal experimental design techniques can reduce the standard error of biodosimetric dose estimations. Conclusions:Optimal experimental design techniques jointly with practitioners' requirements may be applied. This practice would not involve an additional laboratory work.
  • Autores: Antony, Jiju; Viles Díez, Elisabeth; Fonseca, Alexandre; et al.
    Revista: THE TQM JOURNAL
    ISSN: 1754-2731 Vol.32 N° 6 2020 págs. 1159 - 1175
  • Autores: Englund, E. K.; Fernández Seara, María Asunción; Rodríguez-Soto, A. E.; et al.
    Revista: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
    ISSN: 0271-678X Vol.40 N° 7 2020 págs. 1501-1516
    Resumen
    Functional MRI (fMRI) can identify active foci in response to stimuli through BOLD signal fluctuations, which represent a complex interplay between blood flow and cerebral metabolic rate of oxygen (CMRO2) changes. Calibrated fMRI can disentangle the underlying contributions, allowing quantification of the CMRO2 response. Here, whole-brain venous oxygen saturation (Y-v ) was computed alongside ASL-measured CBF and BOLD-weighted data to derive the calibration constant, M, using the proposed Y-v -based calibration. Data were collected from 10 subjects at 3T with a three-part interleaved sequence comprising background-suppressed 3D-pCASL, 2D BOLD-weighted, and single-slice dual-echo GRE (to measure Y (v) via susceptometry-based oximetry) acquisitions while subjects breathed normocapnic/normoxic, hyperoxic, and hypercapnic gases, and during a motor task. M was computed via Y-v -based calibration from both hypercapnia and hyperoxia stimulus data, and results were compared to conventional hypercapnia or hyperoxia calibration methods. Mean M in gray matter did not significantly differ between calibration methods, ranging from 8.5 +/- 2.8% (conventional hyperoxia calibration) to 11.7 +/- 4.5% (Y-v-based calibration in response to hyperoxia), with hypercapnia-based M values between (p = 0.56). Relative CMRO2 changes from finger tapping were computed from each M map. CMRO2 increased by similar to 20% in the motor cortex, and good agreement was observed between the conventional and proposed calibration methods.
  • Autores: Mendichovszky, I.; Pullens, P. ; Dekkers, I.; et al.
    Revista: MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
    ISSN: 0968-5243 Vol.33 N° 1 2020 págs. 131 - 140
    Resumen
    Purpose The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. The PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on renal MRI. Methods A task force was formed in July 2018 focused on five methods. A draft process for attaining consensus was distributed publicly for consultation and finalised at an open meeting (Prague, October 2018). Four expert panels completed surveys between October 2018 and March 2019, discussed results and refined the surveys at a face-to-face meeting (Aarhus, March 2019) and completed a second round (May 2019). Results A seven-stage process was defined: (1) formation of expert panels; (2) definition of the context of use; (3) literature review; (4) collection and comparison of MRI protocols; (5) consensus generation by an approximate Delphi method; (6) reporting of results in vendor-neutral and vendor-specific terms; (7) ongoing review and updating. Application of the process resulted in 166 consensus statements. Conclusion The process generated meaningful technical recommendations across very different MRI methods, while allowing for improvement and refinement as open issues are resolved. The results are likely to be widely supported by the renal MRI community and thereby promote more harmonisation.
  • Autores: Garcia-Rodenas, R. (Autor de correspondencia); Garcia-Garcia, J. C.; López Fidalgo, Jesús Fernando; et al.
    Revista: COMPUTATIONAL STATISTICS AND DATA ANALYSIS
    ISSN: 0167-9473 Vol.144 2020 págs. 106844
    Resumen
    Several common general purpose optimization algorithms are compared for finding A- and D-optimal designs for different types of statistical models of varying complexity, including high dimensional models with five and more factors. The algorithms of interest include exact methods, such as the interior point method, the Nelder Mead method, the active set method, the sequential quadratic programming, and metaheuristic algorithms, such as particle swarm optimization, simulated annealing and genetic algorithms. Several simulations are performed, which provide general recommendations on the utility and performance of each method, including hybridized versions of metaheuristic algorithms for finding optimal experimental designs. A key result is that general-purpose optimization algorithms, both exact methods and metaheuristic algorithms, perform well for finding optimal approximate experimental designs. (C) 2019 Elsevier B.V. All rights reserved.
  • Autores: Beltrán, A. P.; Benítez Sastoque, Edgar Ricardo; Rondon, M.; et al.
    Revista: BREAST CANCER
    ISSN: 1178-2234 Vol.14 2020 págs. UNSP 1178223420904939
    Resumen
    PURPOSE: Ubiquitin ligase genes can act as oncogenes or tumor suppressor genes. They play a role in various diseases, including development and progression of breast cancer; the objective of this study was to evaluate the association of common variants in the ductal-epithelium-associated RING chromosome 1 (DEAR1) gene with breast cancer risk in a sample of Colombian population. METHODS: We carried out a case-control study to investigate associations of variants in DEAR1 with breast cancer in women from Colombia. Single nucleotide polymorphisms (SNPs) rs584298, rs2927970, rs59983645, and rs599167 were genotyped in 1022 breast cancer cases and 1023 healthy controls using the iPLEX (R) and Kompetitive Allele Specific PCR ( polymerase chain reaction) (KASP) method. The associations between SNPs and breast cancer were examined by conditional logistic regression. The associations between SNPs and epidemiological/histopathological variables were examined by multinomial logistic regression. RESULTS : Associations were found between tag SNPs and breast cancer adjusted for the epidemiological risk factors rs584298 genotypes AG and GG (P =.048 and P =.004, respectively). The analysis of the disease characteristics showed that SNP rs584298 (genotype AG) (P =.015) shows association with progesterone receptor (PR) status and (genotype AA) (P =.048) shows association with human epidermal growth factor receptor 2 (HER2) status. CONCLUSIONS : The SNP rs584298 in DEAR1 showed associations with breast cancer and the expression of HER2 receptor; when this receptor is amplified, the result is aggressive tumoral subtype and expression of PR receptor that is associated with high-proliferative tumor grade. Validation of this SNP is important to establish whether this variant or the tagged variant is the cause for the risk association showed.
  • Autores: Bueicheku, E.; Aznárez Sanado, Maite; Diez, I.; et al.
    Revista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    ISSN: 0027-8424 Vol.117 N° 12 2020 págs. 6836 - 6843
    Resumen
    Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader-Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. We found the genetic expression of four genes-TBR1, SCN1A, MAGEL2, and CACNB4-to be prominently associated with visuomotor integrators in the human cortex. TBR1 gene transcripts, an ASD gene whose expression is related to neural development of the cortex and the hippocampus, showed a central spatial allocation within the VMI system. Our findings delineate gene expression traits underlying the VMI system in the human cortex, where specific genes, such as TBR1, are likely to play a central role in its neuronal organization, as well as on specific phenotypes of neurogenetic syndromes.
  • Autores: Lleo De Nalda, Álvaro (Autor de correspondencia); Viles Díez, Elisabeth; Jurburg, D. ; et al.
    Revista: INTERNATIONAL JOURNAL OF QUALITY AND SERVICE SCIENCES
    ISSN: 1756-669X Vol.12 N° 3 2020 págs. 229 - 245
    Resumen
    Purpose This paper aims to identify key middle manager trustworthy behaviours that encourage employees' participation in continuous improvement activities in industrial contexts. Design/methodology/approach The list of behaviours has been developed in two different phases. First, the authors conducted two concept mappings with operators and middle managers and, subsequently, the authors combined and integrated both points of view. Second, the authors developed an expert panel with researchers, consultants and experienced practitioners of industrial management for debugging and reducing the results, presenting the final list of behaviours. Findings This work presents 55 different middle manager trustworthy behaviours divided into four different categories: human qualities; training and development; technical and managerial competencies; and team building. Research limitations/implications This paper contributes to existing literature about sustainable continuous improvement systems highlighting the role of middle managers and proposes a set of specific middle manager trustworthy behaviours for increasing supervisors' influence on operator participation. Originality/value After extracting the knowledge of different stakeholders, the list of behaviours identified can serve as a useful tool for recruiting, training, evaluating and developing a supervisors' managerial style that enhances operator participation in continuous improvement activities.
  • Autores: Nery, F.; Buchanan, C. E. ; Harteveld, A. A. ; et al.
    Revista: MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
    ISSN: 0968-5243 Vol.33 N° 1 2020 págs. 141 - 161
    Resumen
    Objectives This study aimed at developing technical recommendations for the acquisition, processing and analysis of renal ASL data in the human kidney at 1.5 T and 3 T field strengths that can promote standardization of renal perfusion measurements and facilitate the comparability of results across scanners and in multi-centre clinical studies. Methods An international panel of 23 renal ASL experts followed a modified Delphi process, including on-line surveys and two in-person meetings, to formulate a series of consensus statements regarding patient preparation, hardware, acquisition protocol, analysis steps and data reporting. Results Fifty-nine statements achieved consensus, while agreement could not be reached on two statements related to patient preparation. As a default protocol, the panel recommends pseudo-continuous (PCASL) or flow-sensitive alternating inversion recovery (FAIR) labelling with a single-slice spin-echo EPI readout with background suppression and a simple but robust quantification model. Discussion This approach is considered robust and reproducible and can provide renal perfusion images of adequate quality and SNR for most applications. If extended kidney coverage is desirable, a 2D multislice readout is recommended. These recommendations are based on current available evidence and expert opinion. Nonetheless they are expected to be updated as more data become available, since the renal ASL literature is rapidly expanding.
  • Autores: López Fidalgo, Jesús Fernando; Amo-Salas, M. (Autor de correspondencia)
    Revista: RADIATION PHYSICS AND CHEMISTRY
    ISSN: 0969-806X Vol.174 2020 págs. 108917
    Resumen
    In this paper, the tools provided by the theory of Optimal Experimental Design are applied to a nonlinear calibration model. This is motivated by the need of estimating radiation doses using radiochromic films for radiotherapy purposes. The calibration model is in this case nonlinear and the explanatory variable cannot be worked out explicitly from the model. In this case an experimental design has to be found on the dependent variable. For that, the inverse function theorem will be used to obtain an information matrix to be optimized. Optimal designs on the response variable are computed from two different perspectives, first for fitting the model and estimating each of the parameters and then for predicting the proper dose. While the first is a common point of view in a general context of the Optimal Experimental Design, the latter is actually the main objective of the calibration problem for the practitioners and algorithms for computing these optimal designs are also provided. The optimal designs obtained have just three different points in their support, but practitioners usually demand for more support points. Thus, a methodology for computing space-filling designs is also provided when the support points are forced to follow some mathematical rule, such as arithmetic or geometric sequences. Cross efficiencies of all these designs are computed in order to show their ability for different goals.
  • Autores: Iriarte Redín, Concha (Autor de correspondencia); Ibarrola García, Sara; Aznárez Sanado, Maite
    Revista: REVISTA ESPAÑOLA DE PEDAGOGIA
    ISSN: 0034-9461 Vol.78 N° 276 2020 págs. 309 - 326
    Resumen
    This study is part of a research project into coexistence and school mediation. Its aim is to develop a tool (short version) to measure moral, emotional, and socio-cognitive training and the socio-personal impact of mediation on mediating pupils and teachers and mediated pupils. The theoretical starting model on which the development of this tool is based is the Educational Model for Development of Competences through. Mediation (EMODESM). Methodology: the design is based on combining three previously-published questionnaires to create a single tool for evaluating mediation. The construct validity of this tool was studied in two phases. First, a sample of school students (n = 102) from Navarra (Spain) was evaluated, which gave rise to the revision of the tool. Second, the construct validity (confirmatory and exploratory factor analysis) and reliability (Cronbach's alpha [alpha]) of the revised tool were assessed with a new sample of school students (n = 140) from the Autonomous Community of Valencia. Results: we present a mediation assessment tool (MEQ) with 23 items and four dimensions: social impact, the interpersonal emotional area, the personal emotional area, and the moral cognition area. The reliability of the questionnaire showed appropriate values (alpha(Total) = 0.9497; alpha(Perception-SocialImpact) = 0.7896 ; alpha(EmotionalInterpersoal) = 0.7690; alpha(EmouonalPersonal) =0.8672; alpha(CognitiveMoral) = 0.9402). Discussion: the structure of factors shown by the MEQ
  • Autores: Ferrando, C. (Autor de correspondencia); Mellado-Artigas, R.; Gea Sánchez, Alfredo; et al.
    Revista: REVISTA ESPAÑOLA DE ANESTESIOLOGÍA Y REANIMACION
    ISSN: 0034-9356 Vol.67 N° 8 2020 págs. 425 - 437
    Resumen
    Background: The clinical course of COVID-19 critically ill patients, during their admission in the intensive care unit (UCI), including medical and infectious complications and support therapies, as well as their association with in-ICU mortality has not been fully reported. Objective: This study aimed to describe clinical characteristics and clinical course of ICU COVID-19 patients, and to determine risk factors for ICU mortality of COVID-19 patients. Methods Prospective, multicentre, cohort study that enrolled critically ill COVID-19 patients admitted into 30 ICUs from Spain and Andorra. Consecutive patients from March 12th to May 26th, 2020 were enrolled if they had died or were discharged from ICU during the study period. Demographics, symptoms, vital signs, laboratory markers, supportive therapies, pharmacological treatments, medical and infectious complications were reported and compared between deceased and discharged patients. Results: A total of 663 patients were included. Overall ICU mortality was 31% (203 patients). At ICU admission non-survivors were more hypoxemic [SpO2 with non-rebreather mask, 90 (IQR 83 to 93) vs. 91 (IQR 87 to 94); P<.001] and with higher sequential organ failure assessment score [SOFA, 7 (IQR 5 to 9) vs. 4 (IQR 3 to 7); P<.001]. Complications were more frequent in non-survivors: acute respiratory distress syndrome (ARDS) (95% vs. 89%; P=.009), acute kidney injury (AKI) (58% vs. 24%; P<10-16), shock (42% vs. 14%; P<10-13), and arrhythmias (24% vs. 11%; P<10-4). Respiratory super-infection, bloodstream infection and septic shock were higher in non-survivors (33% vs. 25%; P=.03, 33% vs. 23%; P=.01 and 15% vs. 3%, P=10-7), respectively. The multivariable regression model showed that age was associated with mortality, with every year increasing risk-of-death by 1% (95%CI: 1 to 10, P=.014). Each 5-point increase in APACHE II independently predicted mortality [OR: 1.508 (1.081, 2.104), P=.015]. Patients with AKI [OR: 2.468 (1.628, 3.741), P<10-4)], cardiac arrest [OR: 11.099 (3.389, 36.353), P=.0001], and septic shock [OR: 3.224 (1.486, 6.994), P=.002] had an increased risk-of-death. Conclusions: Older COVID-19 patients with higher APACHE II scores on admission, those who developed AKI grades ii or iii and/or septic shock during ICU stay had an increased risk-of-death. ICU mortality was 31%.
  • Autores: Pereira-Sanchez, V. ; Franco, A.; de Castro Manglano, María Pilar; et al.
    Revista: BIOLOGICAL PSYCHIATRY
    ISSN: 0006-3223 Vol.87 N° 9 2020 págs. S19 - S20
  • Autores: Galera Peral, Francisco; García del Barrio, Pedro; Mendi Güemes, Pedro (Autor de correspondencia)
    Revista: JOURNAL OF REGULATORY ECONOMICS
    ISSN: 0922-680X Vol.55 N° 1 2019 págs. 33 - 45
    Resumen
    A well-known result with important policy implications is that an output increase is a necessary condition for social welfare to increase with third-degree price discrimination. In this paper, we explore the robustness of this result to the introduction of an assumption that is different than the conventional approach, namely preferences not being quasilinear. We show that in the presence of income differences among consumers, the aggregate utility of consumers may increase with price discrimination while total output remains constant. This result questions the general policy recommendation that third-degree price discrimination should be disapproved because it reduces welfare unless output increases. Our result highlights the crucial role of the assumption of quasilinear preferences in standard welfare calculations. In the presence of income differences, consumer surplus may be a biased welfare measure, thus potentially leading to incorrect conclusions when assessing the impact of specific policies.
  • Autores: López Fidalgo, Jesús Fernando (Autor de correspondencia); Sánchez, J. G.
    Revista: STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT
    ISSN: 1436-3240 Vol.33 N° 3 2019 págs. 905 - 914
    Resumen
    Bioassays are applied to workers and other people exposed to radiation through routine or accidental intake of radioactive isotopes. The quantity of the isotope intake by an individual can be estimated from the measured quantities in the bioassays using the corresponding retention or excretion function. A retention (excretion) function represents the predicted activity of a radionuclide in the body, organ, or tissue or in a 24-h excreta at a particular time after the intake. The International Commission on Radiological Protection provides these biokinetic models. We have used these functions to compute optimal experimental designs for estimating the intake quantity in workers following radionuclide inhalation or ingestion. In particular, we have considered the case where the individual is exposed to a constant intake during some periods followed by other periods without intakes, which we called multiple constant intakes. The main aim of this work is finding the best times where the bioassay samples should be obtained in order to estimate optimally the actual intake of the last period. The problem is also extended to compute the next two or more bioassays to be performed. Measurements on the same worker are modeled through a correlation structure. The outline of the problem is established for a general case and results are given for a typical case as a real example. The methodology given in the paper can be applied to other cases with multiple constant intakes, e.g. in medical treatments where the patient is exposed to successive doses during particular periods.
  • Autores: Portilla Manjón, Idoia
    Revista: NUEVAS TENDENCIAS
    ISSN: 1139-8124 Vol.102 2019 págs. 10 - 16
    Resumen
    En la era del Big Data las empresas se enfrentan al reto de manejar datos que puedan permitir la identificación del sujeto. La legislación no nos impide acumular información pero, si se trata de datos personales, nos exige protegerlos adecuadamente.
  • Autores: Zazpe García, Itzíar; Santiago Neri, Susana; de la Fuente Arrillaga, María del Carmen; et al.
    Revista: JMIR PUBLIC HEALTH AND SURVEILLANCE
    ISSN: 2369-2960 Vol.5 N° 4 2019 págs. e11997
    Resumen
    Web-based questionnaires allow collecting data quickly, with minimal costs from large sample groups and through Web-based self-administered forms. Until recently, there has been a lack of evidence from large-scale epidemiological studies and nutrition surveys that have evaluated the comparison between traditional and new technologies to measure dietary intake.
  • Autores: Ángel-Rendón, S. V.; Filomena-Ambrosio, A.; Cordon-Díaz, S.; et al.
    Revista: INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
    ISSN: 1878-450X Vol.17 2019 págs. 100164
    Resumen
    Ohmic heating is a novel technique that, until the past two decades, had been underutilized in the industry, particularly because of limitations in the development of applied devices. In recent years, ohmic heating applications have been studied in different varieties of food processing (i.e.: pork, beef, turkey, rice). This technique potentially represents an innovative application for the gastronomic sector. In this research, the aim was to evaluate the application of ohmic cooking regarding water holding capacity, cooking loss and pork short shank colour. Ohmic cooking was used for 2, 2.5, and 3 min at an electric field strength of 21 +/- 1 V/cm, and the results were compared to pan cooking for 13 min. There were no significant differences between the cooking methods regarding cooking loss; however, significant differences concerning water holding capacity and change in colour (Delta E) were found for ohmic cooking treatments at 2 min and 2.5 min, respectively. It was found that for the ohmic cooking process of pork meat samples brined with saltwater concentrations below 2.1% (w/w NaCl), the electrical conductivity values are generally low, and are not sufficient for the cooking of meat samples at these conditions. Thus, ohmic heating of short shank compared to pan cooking represents an advantage with respect to cooking time for the gastronomic sector.
  • Autores: Echarri-Iribarren, V. (Autor de correspondencia); Echarri Iribarren, Fernando; Rizo-Maestre, C.
    Revista: APPLIED ENERGY
    ISSN: 0306-2619 Vol.233 - 234 2019 págs. 959 - 974
    Resumen
    In the field of architecture, there is a growing awareness as to the relevance of using building materials that are produced in same geographical area as the buildings to be constructed. Important implications of these projects include environmental impact reductions deriving from less energy needed for transporting the materials, as well as the activation of the regional economy by promoting local materials. Effects are all the more significant in the case of emblematic buildings with repercussions in the media, in which aesthetic criteria are often placed before functional ones. This study examines the case of the Museu de Bellas Artes de Castellon (the Fine Arts Museum in Castellon, Spain). Cast aluminium recycled panels were used for the facade's finishing material. Based on life cycle analysis (LCA), a comparison with the scenario of having used large-format ceramic panels, produced in the region in which the building is located, is given. A new evaluation methodology, Life Cycle Construction Assessment of Envelopes (LCCA-e) was applied, introducing the analysis of constructive improvements derived from the application of new facade materials. The reduction of derived environmental impacts was evaluated, obtaining 65.6% and 67.7% of the GER and GWP indicators in the production phase and a reduction of these indicators by 87.1% and 86.8% respectively in the complete LCA. This was also due to the reduction of energy needed for transport, as well as a reduction in annual energy demand by 8.55%, evaluated by monitoring, calibration and simulation using EnergyPlus.
  • Autores: Odudu, A. ; Nery, F. ; Harteveld, A. A. ; et al.
    Revista: NEPHROLOGY DIALYSIS TRANSPLANTATION
    ISSN: 0931-0509 Vol.33 N° Suppl. 2 2018 págs. ii15 - ii21
    Resumen
    Renal perfusion provides the driving pressure for glomerular filtration and delivers the oxygen and nutrients to fuel solute reabsorption. Renal ischaemia is a major mechanism in acute kidney injury and may promote the progression of chronic kidney disease. Thus, quantifying renal tissue perfusion is critically important for both clinicians and physiologists. Current reference techniques for assessing renal tissue perfusion have significant limitations. Arterial spin labelling (ASL) is a magnetic resonance imaging (MRI) technique that uses magnetic labelling of water in arterial blood as an endogenous tracer to generate maps of absolute regional perfusion without requiring exogenous contrast. The technique holds enormous potential for clinical use but remains restricted to research settings. This statement paper from the PARENCHIMA network briefly outlines the ASL technique and reviews renal perfusion data in 53 studies published in English through January 2018. Renal perfusion by ASL has been validated against reference methods and has good reproducibility. Renal perfusion by ASL reduces with age and excretory function. Technical advancements mean that a renal ASL study can acquire a whole kidney perfusion measurement in less than 5-10¿min. The short acquisition time permits combination with other MRI techniques that might inform drug mechanisms and renal physiology. The flexibility of renal ASL has yielded several variants of the technique, but there are limited data comparing these approaches. We make recommendations for acquiring and reporting renal ASL data and outline the knowledge gaps that future research should address.
  • Autores: Bulto, R. (Autor de correspondencia); Viles Díez, Elisabeth; Mateo Dueñas, Ricardo
    Revista: PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART B-JOURNAL OF ENGINEERING MANUFACTURE
    ISSN: 0954-4054 Vol.232 N° 5 2018 págs. 755 - 765
    Resumen
    The automotive sector, along with many others, has been subject to two key trends in recent times. The first relates to globalization, in other words, the incorporation of new markets and a growing demand that needs to be satisfied. The second concerns the high expectations of customers regarding quality and the on-going renovation of products. The incorporation of new markets results in the expansion of new production centres all over the world, making it necessary to synchronize launches in different parts of the globe. Furthermore, customers' new demands cause shorter product life cycles. Time is seen as the main factor in the success of any new product launch. Particularly, the period that begins when the production has started in a production plant and continues until the planned production rate has been attained (the ramp-up curve). Because launches have become more frequent, the specific importance given to the life of the model is greater. This article has the following objective: provide a thorough review of the literature, focusing on this specific phase in the life cycle of a model in order to identify, compile and extract any relevant information that will enable us to build a theoretical framework for the ramp-up curve. The article begins by analysing the different interpretations of the phases of the launch stage of a new product that exist in the literature, and it concludes with the evidence that ramp-up curves are an item of scientific interest, where the 21% of the papers relating to this item are focused on the automotive sector, where planning and management are the most recurrent themes. Finally, two themes that remain open for further research are detected: the lack of structured organization during the ramp-up phase and knowledge transfer between different launches of the same product in different places.
  • Autores: Jurburg, D.; Viles Díez, Elisabeth; Tanco Rainusso, Martín; et al.
    Revista: TOTAL QUALITY MANAGEMENT AND BUSINESS EXCELLENCE
    ISSN: 1478-3363 Vol.29 N° 7-8 2018 págs. 817 - 833
    Resumen
    Continuous improvement (CI) systems still have room for improvement due to the difficulty in sustaining the system and attaining a high level of employee participation. This study looks to analyse the level of implementation in manufacturing companies of 16 CI routines, and how these routines foster CI and employee participation. Based on a general survey of CI managers from Spain which yielded 147 valid responses, a Cluster Analysis (CA) and a Factorial Analysis were performed in order to group both responses and the variables used into more comprehensive categories. Statistical tests were run to test for significant relationships. This paper introduces a new perspective on the issue of CI maturity levels by using CA to group companies into three categories based on the score of a set of 16 CI enablers, which were in turn reduced to four factors using Factor Analysis, allowing for the identification of improvement challenges depending on the maturity stage of each company. Three different maturity groups of companies were identified, named as Leaders, Followers and Laggards. Results show that companies with better scores on these factors believe to have more sustainable CI systems and a higher level of employee participation.
  • Autores: Portilla Manjón, Idoia
    Revista: OBSERVATORIO
    ISSN: 1646-5954 Vol.12 N° 3 2018 págs. 66 - 82
  • Autores: Charitopoulou, E.; García Manglano, Javier
    Revista: JOURNAL OF ETHNIC AND MIGRATION STUDIES
    ISSN: 1369-183X Vol.44 N° 5 2018 págs. 849 - 869
    Resumen
    In this paper, we examine the association between contact with migrant populations and support for the populist radical right (PRR) in Switzerland. Building on group threat and intergroup contact theories, which offer opposing predictions, and drawing on Appadurai¿s thesis of the `fear of small numbers¿, we propose a new theoretical framework to explain this association. We predict that the relationship between the size of the migrant populations and PRR voting is nonlinear: a small but noticeable minority triggers the formation of anti-immigrant attitudes, which soften as the minority grows and people start having meaningful interactions with foreigners. To test these theories, we combine individual-level data with municipality-level information. Mixed-effects multilevel models confirm that individuals in municipalities with a moderate proportion of foreigners are more likely than those with fewer or a greater number of migrants to cast their vote in support of PRR parties; this is particularly so for certain stigmatised minorities. We further explore the effect of perceived immigrant threat in moderating these relationships.
  • Autores: Vargas, D.; López, C.; Acero, E.; et al.
    Revista: PLOS ONE
    ISSN: 1932-6203 Vol.13 N° 3 2018 págs. e0194269
    Resumen
    The anatomical location of adipose tissue might have direct implications for its functionality and risk of cardiovascular disease. Adipose tissue surrounding blood vessels may be thermogenically more active in specific areas of the body, releasing substances that regulate vascular metabolism. In humans, the phenotypic characteristics of adipose tissue surrounding the aorta and the cardiovascular disease risk that it might entail remain largely unknown. Here, we compared thermogenesis-related molecular features of human periaortic adipose tissue samples with those of subcutaneous adipose tissue, obtained by sternotomy from 42 patients undergoing cardiovascular surgery. To determine the expression of genes related to energy expenditure and the levels of some adipokines, histological examinations, quantitative PCR, and protein expression measurements in adipocyte precursor cells were performed. Periaortic adipocytes were smaller than those from subcutaneous tissue. Moreover, weight gain induced periaortic adipocyte hypertrophy (r = -0.91, p<0.01). Compared to subcutaneous tissue, adiponectin, FABP4, IL-4 and IL-6 was decreased in periaortic adipocytes, whereas FGF21, UCP-1, PGC-1a, CITED1, Omentin and TFAM (Mitochondrial protein) increased. Upon analyzing patients' clinical conditions, it emerged that the levels of PGC-1a both in male (r = -0.48 p<0.04) and female (r = -0.61, p<0.05) and TFAM in male (r = -0.72, p<0.0008) and female (r = -0.86, p<0.002) decreased significantly with progressive weight gain. However, no differences were observed in patients with diabetes mellitus 2 or Hyperlipidemia. Adipocytes surrounding the ascending aorta present markers of major thermogenic activity than those in subcutaneous tissue. Nevertheless, this characteristic might change, due to unfavorable metabolic conditions such as obesity, which is a risk factor for cardiovascular disease.
  • Autores: Montoro Gurich, Carolina
    Revista: FINISTERRA
    ISSN: 0430-5027 Vol.53 N° 109 2018 págs. 71-93
    Resumen
    This paper explores the relationship between immigration and health status variation among Moroccan immigrants from a gender perspective, using data from a cross-sectional ethnographic survey conducted in the Spanish region of Navarre. Results show, against the literature, that women have a better health status variation than men, probably because men have a higher age profile and a longer stay in Spain. The binary logistic regression reveals important differences in social determinants by gender. Paid employment is the most positive, significant factor for health among women. Close social ties with compatriots, living in an inexpensive old house and, to a lesser extent, having a secondary level of educational achievement are the key factors for men. The economic implications of daily life have an impact on the health of Moroccan immigrants of both sexes.
  • Autores: Portilla Manjón, Idoia
    Revista: INVESTIGACION Y MARKETING
    ISSN: 1131-6144 Vol.Especial 50 aniversario N° Abril 2018 págs. 66 - 68
  • Autores: Portilla Manjón, Idoia
    Libro: Cuadernos de Empresa y Humanismo: Presente y futuro del trabajo
    ISSN: 978-84-8081-698-4 N° 138 2021 págs. 139 - 151
    Resumen
    Las empresas se enfrentan al reto de manejar datos que pueden permitir la identificación del sujeto: los datos personales. Se comentan algunas reglas que nos pueden ayudar a almacenar y gestionar los datos de manera ética, sin olvidar algunas obligaciones que nos señala el marco legal, con especial atención a España.
  • Autores: Alegría Murillo, L.; Cía Mina, Álvaro; López Fidalgo, Jesús Fernando
    Libro: Tratado de Derecho digital
    ISSN: 978-84-18662-22-5 2021 págs. 284 - 302
  • Autores: Benítez Sastoque, Edgar Ricardo
    Libro: Tratado de Derecho digital
    ISSN: 974-84-18662-22-5 2021 págs. 320 - 323
  • Autores: Ku, M. C.; Fernández Seara, María Asunción; Kober, F.; et al.
    Libro: Preclinical MRI of the Kidney: Methods and Protocols
    ISSN: 978-1-0716-0978-1 Vol.2216 2021 págs. 229 - 239
    Resumen
    The kidney is a complex organ involved in the excretion of metabolic products as well as the regulation of body fluids, osmolarity, and homeostatic status. These functions are influenced in large part by alterations in the regional distribution of blood flow between the renal cortex and medulla. Renal perfusion is therefore a key determinant of glomerular filtration. Therefore the quantification of regional renal perfusion could provide important insights into renal function and renal (patho)physiology. Arterial spin labeling (ASL) based perfusion MRI techniques, can offer a noninvasive and reproducible way of measuring renal perfusion in animal models. This chapter addresses the basic concept of ASL-MRI.
  • Autores: Sempere Souvannavong, Juan-David; Montoro Gurich, Carolina; Parreño Castellano, Juan Manuel; et al.
    Libro: Población y territorio: España tras la crisis de 2008
    ISSN: 978-84-9045-911-9 2020 págs. 1 - 10
  • Autores: Pons Izquierdo, Juan José; Montoro Gurich, Carolina
    Libro: Población y territorio: España tras la crisis de 2008
    ISSN: 978-84-9045-911-9 2020 págs. 175 - 190
    Resumen
    El envejecimiento demográfico es una cuestión preocupante desde muchos puntos de vista, incluyendo la localización espacial de los mayores. Y si bien este fenómeno afecta preferentemente al mundo rural, son cada vez más frecuentes los barrios de las ciudades cuya población se encuentran en un avanzado estado de envejecimiento. De todo ello se derivan evidentes consecuencias sociales, de movilidad, asistenciales, etc. Y, por eso, siempre se considera este aspecto a la hora de analizar la vulnerabilidad de las diferentes zonas urbanas. Desde esta perspectiva, el presente trabajo tiene por objetivos (1) establecer una metodología adecuada para la delimitación de lo que hoy en día puede considerarse un barrio envejecido y (2) mostrar como resultado la situación de este fenómeno por áreas urbanas, utilizando los últimos datos padronales disponibles (2017), a escala de sección censal.
  • Autores: Montoro Gurich, Carolina
    Libro: Studium, magisterium et amicitia: homenaje al profesor Agustín González Enciso
    ISSN: 978-84-7768-350-6 2018 págs. 625 - 636
  • Autores: López Fidalgo, Jesús Fernando; Tommasi, C.
    Libro: The mathematics of the uncertain. A tribute to Pedro Gil
    ISSN: 978-3-319-73847-5 2018 págs. 253 - 263
    Resumen
    Model selection is a core topic in modern Statistics. This is a review of what has been researched on optimal experimental design for model selection. The aim is to find good designs for increasing the test power for discriminating between rival models. This topic has a special impact nowadays in the area of experimental design.

Proyectos desde 2018

  • Título: Diseños aproximados óptimos para modelos no lineales con observaciones correlacionadas en aplicaciones reales
    Código de expediente: PRX22/00428
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: MINISTERIO DE EDUCACION , CULTURA Y DEPORTE
    Convocatoria: 2023 MECD Movilidad SENIOR
    Fecha de inicio: 01-01-2024
    Fecha fin: 31-03-2024
    Importe concedido: 11.353,00€
    Otros fondos: -
  • Título: PLATAFORMA INTELIGENTE y CYBERSEGURA PARA OPTIMIZACION ADAPTATIVA EN LA OPERACIÓN SIMULTANEA DE ROBOTS AUTONOMOS HETEROGENEOS
    Código de expediente: PLEC2023-010353
    Investigador principal: DARIAN HORACIO GRASS BOADA, JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: AGENCIA ESTATAL DE INVESTIGACION
    Convocatoria: 2023 AEI Transmisiones (CDTI)
    Fecha de inicio: 01-01-2024
    Fecha fin: 31-12-2026
    Importe concedido: 345.582,00€
    Otros fondos: Fondos MRR
  • Título: Procesamiento Natural del Lenguaje y Medicina Personalizada.
    Código de expediente: 0011-4001-2023-000071
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2023 GN Investigo
    Fecha de inicio: 10-10-2023
    Fecha fin: 09-10-2024
    Importe concedido: 33.003,92€
    Otros fondos: Fondos MRR
  • Título: Preprocesamiento, limpieza e ingeniería de datos
    Código de expediente: 0011-4001-2023-000072
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2023 GN Investigo
    Fecha de inicio: 10-10-2023
    Fecha fin: 09-10-2024
    Importe concedido: 33.003,92€
    Otros fondos: Fondos MRR
  • Título: OpenSNR ¿ Software para elAnálisis Automático de la Relación
    Código de expediente: 1.1.401553
    Investigador principal: MARIA ASUNCION FERNANDEZ SEARA.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2023 GN I+D Transferencia del conocimiento (empresas)
    Fecha de inicio: 01-09-2023
    Fecha fin: 31-07-2025
    Importe concedido: 0
    Otros fondos: Fondos FEDER
  • Título: Smart Green Campus como LivingLAB, GREENLAB
    Código de expediente: 0011-1411-2023-000099
    Investigador principal: CARLOS JAVIER NAYA VILLAVERDE, CARLOS JAVIER NAYA VILLAVERDE.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2023 GN PROYECTOS ESTRATEGICOS DE I+D 2023-2026
    Fecha de inicio: 16-08-2023
    Fecha fin: 31-12-2025
    Importe concedido: 49.712,00€
    Otros fondos: Fondos FEDER
  • Título: Preprocesamiento, limpieza e ingeniería de datos. Análisis estadístico y desarrollo de modelos basados en inteligencia artificial.
    Código de expediente: 0011-4001-2023-000044
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2023 GN Investigo
    Fecha de inicio: 15-06-2023
    Fecha fin: 14-06-2024
    Importe concedido: 33.003,92€
    Otros fondos: Fondos MRR
  • Título: PORTRAIT. A multi-omic stratification and a non invasive tool for early recognition of triple negative and Her2+ breast cancer patients responders to neoadjuvant therapy.
    Código de expediente: 0011-2750-2022-000000
    Investigador principal: RUBEN ARMAÑANZAS ARNEDILLO, RUBEN ARMAÑANZAS ARNEDILLO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2022 GN ERA PERMED
    Fecha de inicio: 10-05-2023
    Fecha fin: 05-03-2026
    Importe concedido: 311.184,00€
    Otros fondos: -
  • Título: Limpieza y preprocesamiento de datos relativos a proyectos de investigación. Desarrollo de modelos de machine learning aplicados al Procesamiento Natural del Lenguaje y el medicina personalizada
    Código de expediente: 0011-4001-2022-000040
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2021 GN Investigo
    Fecha de inicio: 10-10-2022
    Fecha fin: 09-10-2023
    Importe concedido: 33.108,92€
    Otros fondos: Fondos MRR
  • Título: 0011-4001-2022-000041 Limpieza y preprocesamiento de datos relativos a proyectos de investigación. Desarrollo de modelos de machine learning aplicados al Procesamiento Natural del Lenguaje y el medicina personalizada
    Código de expediente: 0011-4001-2022-000041
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2021 GN Investigo
    Fecha de inicio: 10-10-2022
    Fecha fin: 09-10-2023
    Importe concedido: 33.108,92€
    Otros fondos: Fondos MRR
  • Título: PERSONIA
    Código de expediente: 0011-1365-2022-000225
    Investigador principal: DARIAN HORACIO GRASS BOADA.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2022 GN I+D Transferencia del conocimiento (empresas)
    Fecha de inicio: 01-10-2022
    Fecha fin: 31-05-2024
    Importe concedido: 52.745,86€
    Otros fondos: Fondos FEDER
  • Título: Limpieza de la base de datos de registros de contaminación atmosférica.Aplicación de técnicas avanzadas para la corrección de datos espaciales.
    Código de expediente: 0011-4001-2022-000010
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2021 GN Investigo
    Fecha de inicio: 15-06-2022
    Fecha fin: 14-06-2023
    Importe concedido: 33.108,92€
    Otros fondos: Fondos MRR
  • Título: Gemelos Digitales para la climatización de edificios (BuildTwin)
    Código de expediente: 0011-1383-2022-000015 PC032-033 BuildTwin
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO, JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2022 GN Proyectos Colaborativos
    Fecha de inicio: 01-04-2022
    Fecha fin: 30-11-2024
    Importe concedido: 370.917,55€
    Otros fondos: -
  • Título: Inteligencia Artificial aplicada a la Medicina
    Código de expediente: 0011-3947-2021-000023
    Investigador principal: RUBEN ARMAÑANZAS ARNEDILLO, RUBEN ARMAÑANZAS ARNEDILLO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2021 GN Andia - Atracción de talento
    Fecha de inicio: 01-03-2022
    Fecha fin: 28-02-2027
    Importe concedido: 500.000,00€
    Otros fondos: -
  • Título: RICORS2040
    Código de expediente: RD21/0005/0024
    Investigador principal: NURIA GARCIA FERNANDEZ.
    Financiador: INSTITUTO DE SALUD CARLOS III
    Convocatoria: 2021 AES Redes de Investigación cooperativa orientadas a resultados (RICORS)
    Fecha de inicio: 01-01-2022
    Fecha fin: 31-12-2024
    Importe concedido: 105.765,00€
    Otros fondos: Fondos FEDER
  • Título: Resonancia magnética cardíaca multiparamétrica para la detección de isquemia, sin la utilización de gadolinio
    Código de expediente: PI21/00578
    Investigador principal: MARIA ASUNCION FERNANDEZ SEARA.
    Financiador: INSTITUTO DE SALUD CARLOS III
    Convocatoria: 2021 AES Proyectos de investigación
    Fecha de inicio: 01-01-2022
    Fecha fin: 31-12-2024
    Importe concedido: 65.340,00€
    Otros fondos: Fondos FEDER
  • Título: Diseños Experimentales en Investigación Industrial Salud y Tratamiento de Grandes Cantidades de Datos
    Código de expediente: PID2020-113443RB-C21
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO, RAÚL MARTÍN MARTÍN.
    Financiador: AGENCIA ESTATAL DE INVESTIGACION
    Convocatoria: 2020 AEI PROYECTOS I+D+i (incluye Generación del conocimiento y Retos investigación)
    Fecha de inicio: 01-09-2021
    Fecha fin: 31-08-2025
    Importe concedido: 50.820,00€
    Otros fondos: -
  • Título: Renal MRI standardization to improve personalised management of CKD patients (RESPECT)
    Código de expediente: 0011-2750-2020-000001
    Investigador principal: MARIA ASUNCION FERNANDEZ SEARA.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: ERA PerMed JTC2020
    Fecha de inicio: 01-06-2021
    Fecha fin: 31-10-2024
    Importe concedido: 242.284,00€
    Otros fondos: -
  • Título: Desarrollo y validación de una herramienta digital basada en inteligencia artificial para la detección de publicaciones científicas relevantes en la toma de decisiones relacionadas con la Covid-19 Proyecto "Covid Content Curation".
    Código de expediente: 011-3638-2020-000001
    Investigador principal: JORGE MARIA NUÑEZ CORDOBA.
    Financiador: GOBIERNO DE NAVARRA. DEPARTAMENTO DE SALUD
    Convocatoria: 2020 GN Proyectos de Investigación en salud
    Fecha de inicio: 01-01-2021
    Fecha fin: 31-12-2021
    Importe concedido: 20.700,00€
    Otros fondos: -
  • Título: Binge-drinking: peor calidad de vida, riesgo de cáncer y de envejecimiento no saludable.
    Código de expediente: 2020I021
    Investigador principal: ALFREDO GEA SANCHEZ.
    Financiador: MINISTERIO DE SANIDAD, SERVICIOS SOCIALES E IGUALDAD
    Convocatoria: 2020 MSanidad Investigación en Drogodependencias
    Fecha de inicio: 01-01-2021
    Fecha fin: 31-12-2023
    Importe concedido: 45.509,38€
    Otros fondos: -
  • Título: Desarrollo y evaluación de una técnica de imagen por resonancia magnética multiparamétrica para predecir de forma precoz la disfunción del injerto renal tras el trasplante,. RM-RENAL.
    Código de expediente: 0011-1383-2020-000010 PC181 RM-RENAL
    Investigador principal: MARIA ASUNCION FERNANDEZ SEARA, PALOMA LETICIA MARTIN MORENO.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2020 GN Proyectos Colaborativos
    Fecha de inicio: 01-01-2020
    Fecha fin: 30-11-2022
    Importe concedido: 164.349,50€
    Otros fondos: -
  • Título: Solicitud ayuda movilidad Senior
    Código de expediente: PRX18/00339
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO.
    Financiador: MINISTERIO DE EDUCACION , CULTURA Y DEPORTE
    Convocatoria: 2018 MECD SENIOR
    Fecha de inicio: 01-07-2019
    Fecha fin: 30-09-2019
    Importe concedido: 9.981,00€
    Otros fondos: -
  • Título: Desarrollo de técnicas de mapeado de la reactividad cerebrovascular. Aplicaciones en la cirugía de tumores cerebrales.
    Código de expediente: PI18/00084
    Investigador principal: MARIA ASUNCION FERNANDEZ SEARA.
    Financiador: INSTITUTO DE SALUD CARLOS III
    Convocatoria: AES2018 PI
    Fecha de inicio: 01-01-2019
    Fecha fin: 30-06-2023
    Importe concedido: 62.920,00€
    Otros fondos: Fondos FEDER
  • Título: De la arquitectura de la escucha a la huella social: buenas prácticas en la producción de contenidos
    Código de expediente: RTI2018-101124-B-I00
    Investigador principal: MARIA DE LAS MERCEDES MEDINA LAVERON, PATRICIA DIEGO GONZALEZ.
    Financiador: MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES
    Convocatoria: 2018 AEI - MCIU - Retos Investigación
    Fecha de inicio: 01-01-2019
    Fecha fin: 30-09-2022
    Importe concedido: 30.250,00€
    Otros fondos: Fondos FEDER
  • Título: USO DE FORMULACIONES POLIMÉRICAS MUCOADHESIVAS PARA LA ERRADICACIÓN DE HELICOBACTER PYLORI
    Código de expediente: RTC-2017-6643-1
    Investigador principal: RAMON JESUS ANGOS MUSGO.
    Financiador: MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES
    Convocatoria: 2017 MINECO RETOS COLABORACIÓN
    Fecha de inicio: 01-07-2018
    Fecha fin: 30-04-2022
    Importe concedido: 148.104,88€
    Otros fondos: Fondos FEDER
  • Título: PLATAFORMA DE UNIDADES DE INVESTIGACION CLINICA Y ENSAYOS CLINICOS Spanish Clinical Research Network (SCReN)
    Código de expediente: PT17/0017/0014
    Investigador principal: JOSE RAMON AZANZA PEREA.
    Financiador: INSTITUTO DE SALUD CARLOS III
    Convocatoria: AES2017 PLATAFORMAS
    Fecha de inicio: 01-01-2018
    Fecha fin: 31-12-2020
    Importe concedido: 102.300,00€
    Otros fondos: Fondos FEDER
  • Título: Devaluación en la toma de decisiones en adultos con TDAH: asociación con estilos de vida y efecto de la medicación
    Código de expediente: PSI2017-86763-P
    Investigador principal: JAVIER BERNACER MARIA, GONZALO ARRONDO OSTIZ.
    Financiador: MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES
    Convocatoria: 2017 MINECO EXCELENCIA
    Fecha de inicio: 01-01-2018
    Fecha fin: 30-09-2021
    Importe concedido: 54.813,00€
    Otros fondos: Fondos FEDER
  • Título: Estudio de la obesidad como factor de riesgo de mortalidad y su prevención mediante recomendaciones dietéticas: Análisis longitudinal de la cohorte SUN.
    Código de expediente: PI17/01795
    Investigador principal: MAIRA BES RASTROLLO.
    Financiador: INSTITUTO DE SALUD CARLOS III
    Convocatoria: AES2017 PROYECTOS DE INVESTIGACIÓN
    Fecha de inicio: 01-01-2018
    Fecha fin: 30-06-2021
    Importe concedido: 93.170,00€
    Otros fondos: Fondos FEDER
  • Título: Juan de la Cierva Formación - JM García Manglano
    Código de expediente: IJCI-2015-26327
    Investigador principal: LUIS RAVINA BOHORQUEZ.
    Financiador: MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES
    Convocatoria: 2015 MINECO JUAN DE LA CIERVA INCORPORACION
    Fecha de inicio: 26-06-2017
    Fecha fin: 25-06-2019
    Importe concedido: 64.000,00€
    Otros fondos: Fondos FEDER
  • Título: Nuevo Sistema Inalámbrico de Antenas de Resonancia Magnética para Imagen de Animales de Laboratorio en Escáners Clínicos
    Código de expediente: 0011-1365-2017-000106
    Investigador principal: MARIA ASUNCION FERNANDEZ SEARA.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2017 GN I+D
    Fecha de inicio: 04-05-2017
    Fecha fin: 30-04-2019
    Importe concedido: 86.879,86€
    Otros fondos: -
  • Título: Ayudas para la Incorporacion de doctores 2017 (I3)
    Código de expediente: IEDI-2017-00826
    Investigador principal: MARIA ASUNCION FERNANDEZ SEARA.
    Financiador: MINISTERIO DE EDUCACION , CULTURA Y DEPORTE
    Convocatoria: 2017 MINECO I3
    Fecha de inicio: 01-01-2017
    Fecha fin: 31-12-2019
    Importe concedido: 100.000,00€
    Otros fondos: Fondos FEDER
  • Título: Determinantes nutricionales del Cáncer de mama
    Código de expediente: 41/2016
    Investigador principal: ESTEFANIA AINHOA TOLEDO ATUCHA.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2016 GN SALUD
    Fecha de inicio: 08-12-2016
    Fecha fin: 08-12-2020
    Importe concedido: 47.004,31€
    Otros fondos: -
  • Título: Ensayo aleatorizado de prevención con dieta mediterránea de arritmias recurrentes (estudio predimar) en pacientes con fibrilación auricular
    Código de expediente: 46/2016
    Investigador principal: MIGUEL RUIZ-CANELA LOPEZ.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2016 GN SALUD
    Fecha de inicio: 08-12-2016
    Fecha fin: 08-12-2019
    Importe concedido: 47.385,16€
    Otros fondos: -
  • Título: Evaluación de la perfusión cerebral y la conectividad funcional en la enfermedad de Alzheimer: Dos marcadores emergentes para un idagnostico temprano.
    Código de expediente: SAF2014-56330-R
    Investigador principal: MARIA ASUNCION FERNANDEZ SEARA.
    Financiador: MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES
    Convocatoria: 2014 - PROYECTOS DE I+D RETOS
    Fecha de inicio: 01-01-2015
    Fecha fin: 30-06-2018
    Importe concedido: 90.750,00€
    Otros fondos: Fondos FEDER
  • Título: Industrial symbiosis, Circular Economy, Sustainability
    Investigador principal: MARIA JESUS ALVAREZ SANCHEZ-ARJONA
    Financiador: UNIVERSIDAD DE NAVARRA
    Convocatoria: 2020 Convocatoria PIUNA, 2021 Convocatoria PIUNA
    Fecha de inicio: 01-09-2020
    Fecha fin: 31-08-2022
    Importe concedido: 22.900,00€
  • Título: HOW VIRTUE ETHICS CAN ENGAGE WITH AI IN BUSINESS
    Investigador principal: ALEJO JOSE SISON GALSIM
    Financiador: UNIVERSIDAD DE NAVARRA
    Convocatoria: 2020 Convocatoria PIUNA, 2021 Convocatoria PIUNA
    Fecha de inicio: 01-09-2020
    Fecha fin: 31-08-2022
    Importe concedido: 18.000,00€
  • Título: Contrato Marco Formación
    Investigador principal: JESUS FERNANDO LOPEZ FIDALGO
    Fecha de inicio: 01-06-2020
    Fecha fin: 31-08-2021
    Importe: 0
    Otros fondos: -
  • Título: Exploring young people's family and relationships attitudes in the transition to adulthood
    Investigador principal: JAVIER GARCIA MANGLANO, MARIA ROSARIO SADABA CHALEZQUER
    Financiador: UNIVERSIDAD DE NAVARRA
    Convocatoria: 2020 Convocatoria PIUNA, 2021 Convocatoria PIUNA, 2019 Convocatoria PIUNA
    Fecha de inicio: 01-09-2019
    Fecha fin: 31-08-2022
    Importe concedido: 183.668,00€