Miembros del Grupo
De la Fuente Cedeño
María de los Ángeles
Líneas de Investigación
- Reprogramación metabólica en cáncer con el fin de identificar nuevas dianas terapéuticas y marcadores de respuesta
- Modelos predictivos de toxicidad de fármacos basados en características estructurales
- Integración de experimentos masivos de silenciamiento génico y fármacos en el marco de la oncología de precisión
- Influencia de la microbiota intestinal en el ámbito de la salud y nutrición
- Inferencia de redes de regulación de genes para datos de RNA provenientes de secuenciación en bulk y single-cell
- Estudio del splicing alternativo en distintos tipos de cáncer: sus alteraciones, causas y efectos
- Esquemas de comprensión específicos para diferentes datos ómicos. Miembros activos en el desarrollo del standard MPEG-G para la representación de datos genómicos
- Desarrollo de métodos computacionales para el análisis en integración de datos ómicos
- Análisis de datos de ADN. Métodos para mejorar la identificación de variantes biológicas en germline y cancer
- Therapeutic Targets
- Single-Cell RNAseq
- Signaling Networks
- Regulatory Networks
- Precision Oncology
- Personalized Nutrición
- Metabolic Networks
- Drug Targets
- Computational Models
- Alternative Splicing
Publicaciones Científicas desde 2018
Autores: Goyal, M.; SERRANO SANZ, Guillermo; Argemí Ballbé, José María; et al.Revista: BIOINFORMATICSISSN 1367-4803 Vol.39 N° 9 2022 págs. 2488 - 2495ResumenMotivation An important step in the transcriptomic analysis of individual cells involves manually determining the cellular identities. To ease this labor-intensive annotation of cell-types, there has been a growing interest in automated cell annotation, which can be achieved by training classification algorithms on previously annotated datasets. Existing pipelines employ dataset integration methods to remove potential batch effects between source (annotated) and target (unannotated) datasets. However, the integration and classification steps are usually independent of each other and performed by different tools. We propose JIND (joint integration and discrimination for automated single-cell annotation), a neural-network-based framework for automated cell-type identification that performs integration in a space suitably chosen to facilitate cell classification. To account for batch effects, JIND performs a novel asymmetric alignment in which unseen cells are mapped onto the previously learned latent space, avoiding the need of retraining the classification model for new datasets. JIND also learns cell-type-specific confidence thresholds to identify cells that cannot be reliably classified. Results We show on several batched datasets that the joint approach to integration and classification of JIND outperforms in accuracy existing pipelines, and a smaller fraction of cells is rejected as unlabeled as a result of the cell-specific confidence thresholds. Moreover, we investigate cells misclassified by JIND and provide evidence suggesting that they could be due to outliers in the annotated datasets or errors in the original approach used for annotation of the target batch.
Autores: Ferrer-Bonsoms, J. A.; Jareño, L.; Rubio Díaz-Cordoves, Ángel (Autor de correspondencia)Revista: BIOINFORMATICSISSN 1367-4803 Vol.38 N° 3 2022 págs. 844 - 845ResumenMotivation: Discover is an algorithm developed to identify mutually exclusive genomic events. Its main contribution is a statistical analysis based on the Poisson-Binomial (PB) distribution to take into account the mutation rate of genes and samples. Discover is very effective for identifying mutually exclusive mutations at the expense of speed in large datasets: the PB is computationally costly to estimate, and checking all the potential mutually exclusive alterations requires millions of tests. Results: We have implemented a new version of the package called Rediscover that implements exact and approximate computations of the PB. Rediscover exact implementation is slightly faster than Discover for large and medium-sized datasets. The approximation is 100-1000 times faster for them making it possible to get results in less than a minute with a standard desktop. The memory footprint is also smaller in Rediscover. The new package is available at CRAN and provides some functions to integrate its usage with other R packages such as maftools and TCGAbiolinks. Availability and implementation: Rediscover is available at CRAN (https://cran.r-project.org/web/packages/ Rediscover/index.html).
Autores: Ferrer-Bonsoms, J. A.; Morales Urteaga, Xabier; Afshar, P. T.; et al.Título: On the identifiability of the isoform deconvolution problem: application to select the proper fragment length in an RNA-seq libraryRevista: BIOINFORMATICSISSN 1367-4803 Vol.38 N° 6 2022 págs. 1491 - 1496ResumenMotivation: Isoform deconvolution is an NP-hard problem. The accuracy of the proposed solutions is far from perfect. At present, it is not known if gene structure and isoform concentration can be uniquely inferred given paired-end reads, and there is no objective method to select the fragment length to improve the number of identifiable genes. Different pieces of evidence suggest that the optimal fragment length is gene-dependent, stressing the need for a method that selects the fragment length according to a reasonable trade-off across all the genes in the whole genome. Results: A gene is considered to be identifiable if it is possible to get both the structure and concentration of its transcripts univocally. Here, we present a method to state the identifiability of this deconvolution problem. Assuming a given transcriptome and that the coverage is sufficient to interrogate all junction reads of the transcripts, this method states whether or not a gene is identifiable given the read length and fragment length distribution. Applying this method using different read and fragment length combinations, the optimal average fragment length for the human transcriptome is around 400-600 nt for coding genes and 150-200 nt for long non-coding RNAs. The optimal read length is the largest one that fits in the fragment length. It is also discussed the potential profit of combining several libraries to reconstruct the transcriptome. Combining two libraries of very different fragment lengths results in a significant improvement in gene identifiability.
Autores: Carrasco-García, E. (Autor de correspondencia); López, L.; Moncho-Amor, V.; et al.Título: SOX9 triggers different epithelial to mesenchymal transition states to promote pancreatic cancer progressionRevista: CANCERSISSN 2072-6694 Vol.14 N° 4 2022 págs. 916ResumenSimple Summary Pancreatic cancers are lethal types of cancer. A majority of patients progress to an advanced and metastatic disease, which remains a major clinical problem. Therefore, it is crucial to identify critical regulators to help predict the disease progression and to develop more efficacious therapeutic approaches. In this work we found that an increased expression of the developmental factor SOX9 is associated with metastasis, a poor prognosis and resistance to therapy in pancreatic ductal adenocarcinoma patients and in cell cultures. We also found that this effect is at least in part due to the ability of SOX9 to regulate the activity of stem cell factors, such as BMI1, in addition to those involved in EMT and metastasis. Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers mainly due to spatial obstacles to complete resection, early metastasis and therapy resistance. The molecular events accompanying PDAC progression remain poorly understood. SOX9 is required for maintaining the pancreatic ductal identity and it is involved in the initiation of pancreatic cancer. In addition, SOX9 is a transcription factor linked to stem cell activity and is commonly overexpressed in solid cancers. It cooperates with Snail/Slug to induce epithelial-mesenchymal transition (EMT) during neural development and in diseases such as organ fibrosis or different types of cancer. Methods: We investigated the roles of SOX9 in pancreatic tumor cell plasticity, metastatic dissemination and chemoresistance using pancreatic cancer cell lines as well as mouse embryo fibroblasts. In addition, we characterized the clinical relevance of SOX9 in pancreatic cancer using human biopsies. Results: Gain- and loss-of-function of SOX9 in PDAC cells revealed that high levels of SOX9 increased migration and invasion, and promoted EMT and metastatic dissemination, whilst SOX9 silencing resulted in metastasis inhibition, along with a phenotypic reversion to epithelial features and loss of stemness potential. In both contexts, EMT factors were not altered. Moreover, high levels of SOX9 promoted resistance to gemcitabine. In contrast, overexpression of SOX9 was sufficient to promote metastatic potential in K-Ras transformed MEFs, triggering EMT associated with Snail/Slug activity. In clinical samples, SOX9 expression was analyzed in 198 PDAC cases by immunohistochemistry and in 53 patient derived xenografts (PDXs). SOX9 was overexpressed in primary adenocarcinomas and particularly in metastases. Notably, SOX9 expression correlated with high vimentin and low E-cadherin expression. Conclusions: Our results indicate that SOX9 facilitates PDAC progression and metastasis by triggering stemness and EMT.
Autores: Perez, S.; Hinojosa, D.; Navajas, B.; et al.Título: Effect of freezing on gut microbiota composition and functionality for in vitro fermentation experimentsRevista: NUTRIENTSISSN 2072-6643 Vol.13 N° 7 2021 págs. 2207ResumenThe gut microbiota has a profound effect on human health and is modulated by food and bioactive compounds. To study such interaction, in vitro batch fermentations are performed with fecal material, and some experimental designs may require that such fermentations be performed with previously frozen stools. Although it is known that freezing fecal material does not alter the composition of the microbial community in 16S rRNA gene amplicon and metagenomic sequencing studies, it is not known whether the microbial community in frozen samples could still be used for in vitro fermentations. To explore this, we undertook a pilot study in which in vitro fermentations were performed with fecal material from celiac, cow¿s milk allergic, obese, or lean children that was frozen (or not) with 20% glycerol. Before fermentation, the fecal material was incubated in a nutritious medium for 6 days, with the aim of giving the microbial community time to recover from the effects of freezing. An aliquot was taken daily from the stabilization vessel and used for the in vitro batch fermentation of lentils. The microbial community structure was significantly different between fresh and frozen samples, but the variation introduced by freezing a sample was always smaller than the variation among individuals, both before and after fermentation.
Autores: Hanau, F.; Rost, H.; Ochoa Álvarez, Idoia (Autor de correspondencia)Revista: BIOINFORMATICSISSN 1367-4803 Vol.37 N° 21 2021 págs. 3923 - 3925ResumenMotivation: Mass spectrometry (MS) data, used for proteomics and metabolomics analyses, have seen considerable growth in the last years. Aiming at reducing the associated storage costs, dedicated compression algorithms for MS data have been proposed, such as MassComp and MSNumpress. However, these algorithms focus on either lossless or lossy compression, respectively, and do not exploit the additional redundancy existing across scans contained in a single file. We introduce mspack, a compression algorithm for MS data that exploits this additional redundancy and that supports both lossless and lossy compression, as well as the mzML and the legacy mzXML formats. mspack applies several preprocessing lossless transforms and optional lossy transforms with a configurable error, followed by the general purpose compressors gzip or bsc to achieve a higher compression ratio. Results: We tested mspack on several datasets generated by commonly used MS instruments. When used with the bsc compression backend, mspack achieves on average 76% smaller file sizes for lossless compression and 94% smaller file sizes for lossy compression, as compared with the original files. Lossless mspack achieves 10-60% lower file sizes than MassComp, and lossy mspack compresses 36-60% better than the lossy MSNumpress, for the same error, while exhibiting comparable accuracy and running time. Supplementary information: Supplementary data are available at Bioinformatics online.
Autores: Zhang, C. Y.; El-Kebir, M.; Ochoa Álvarez, Idoia (Autor de correspondencia)Título: Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samplesRevista: NATURE COMMUNICATIONSISSN 2041-1723 Vol.12 N° 1 2021 págs. 2204ResumenIntra-tumor heterogeneity renders the identification of somatic single-nucleotide variants (SNVs) a challenging problem. In particular, low-frequency SNVs are hard to distinguish from sequencing artifacts. While the increasing availability of multi-sample tumor DNA sequencing data holds the potential for more accurate variant calling, there is a lack of high-sensitivity multi-sample SNV callers that utilize these data. Here we report Moss, a method to identify low-frequency SNVs that recur in multiple sequencing samples from the same tumor. Moss provides any existing single-sample SNV caller the ability to support multiple samples with little additional time overhead. We demonstrate that Moss improves recall while maintaining high precision in a simulated dataset. On multi-sample hepatocellular carcinoma, acute myeloid leukemia and colorectal cancer datasets, Moss identifies new low-frequency variants that meet manual review criteria and are consistent with the tumor's mutational signature profile. In addition, Moss detects the presence of variants in more samples of the same tumor than reported by the single-sample caller. Moss' improved sensitivity in SNV calling will enable more detailed downstream analyses in cancer genomics. The study of tumour heterogeneity can be improved by sequencing multiple samples, but currently available variant callers have not been tailored to integrate them. Here the authors present Moss, a tool that can leverage multiple samples to improve somatic variant calling in different cancers.
Autores: Dufort y Álvarez, G.; Seroussi, G.; Smircich, P.; et al.Revista: BIOINFORMATICSISSN 1367-4803 Vol.37 N° 24 2021 págs. 4862 - 4864ResumenMotivation: Nanopore sequencing technologies are rapidly gaining popularity, in part, due to the massive amounts of genomic data they produce in short periods of time (up to 8.5 TB of data in <72 h). To reduce the costs of transmission and storage, efficient compression methods for this type of data are needed. Results: We introduce RENANO, a reference-based lossless data compressor specifically tailored to FASTQ files generated with nanopore sequencing technologies. RENANO improves on its predecessor ENANO, currently the state of the art, by providing a more efficient base call sequence compression component. Two compression algorithms are introduced, corresponding to the following scenarios: (1) a reference genome is available without cost to both the compressor and the decompressor and (2) the reference genome is available only on the compressor side, and a compacted version of the reference is included in the compressed file. We compare the compression performance of RENANO against ENANO on several publicly available nanopore datasets. RENANO improves the base call sequences compression of ENANO by 39.8% in scenario (1), and by 33.5% in scenario (2), on average, over all the datasets. As for total file compression, the average improvements are 12.7% and 10.6%, respectively. We also show that RENANO consistently outperforms the recent general-purpose genomic compressor Genozip.
Autores: Medina Murua, Andoni (Autor de correspondencia); Bistue García, Guillermo; Rubio Díaz-Cordoves, ÁngelTítulo: Comparison of typical controllers for direct yaw moment control applied on an electric race carRevista: VEHICLESISSN 2624-8921 Vol.3 N° 1 2021 págs. 127 - 144ResumenDirect Yaw Moment Control (DYC) is an effective way to alter the behaviour of electric cars with independent drives. Controlling the torque applied to each wheel can improve the handling performance of a vehicle making it safer and faster on a race track. The state-of-the-art literature covers the comparison of various controllers (PID, LPV, LQR, SMC, etc.) using ISO manoeuvres. However, a more advanced comparison of the important characteristics of the controllers' performance is lacking, such as the robustness of the controllers under changes in the vehicle model, steering behaviour, use of the friction circle, and, ultimately, lap time on a track. In this study, we have compared the controllers according to some of the aforementioned parameters on a modelled race car. Interestingly, best lap times are not provided by perfect neutral or close-to-neutral behaviour of the vehicle, but rather by allowing certain deviations from the target yaw rate. In addition, a modified Proportional Integral Derivative (PID) controller showed that its performance is comparable to other more complex control techniques such as Model Predictive Control (MPC).
Autores: Blasco, T.; Pérez-Burillo, S.; Balzerani, F.; et al.Revista: NATURE COMMUNICATIONSISSN 2041-1723 Vol.12 N° 1 2021 págs. 4728ResumenUnderstanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to systematically address this complex problem. However, when applied to nutritional questions, a major issue in existing reconstructions is the limited information about compounds in the diet that are metabolized by the gut microbiota. Here, we present AGREDA, an extended reconstruction of diet metabolism in the human gut microbiota. AGREDA adds the degradation pathways of 209 compounds present in the human diet, mainly phenolic compounds, a family of metabolites highly relevant for human health and nutrition. We show that AGREDA outperforms existing reconstructions in predicting diet-specific output metabolites from the gut microbiota. Using 16S rRNA gene sequencing data of faecal samples from Spanish children representing different clinical conditions, we illustrate the potential of AGREDA to establish relevant metabolic interactions between diet and gut microbiota. The interplay between human diet and the gut microbiome is complex. Here, the authors present a model of human-microbiome interaction that can predict how phenolic compounds are metabolized by the human gut microbiome, identifying diet-specific metabolites in children of varied clinical conditions.
Autores: Ponce-de-Leon, M. ; Apaolaza Emparanza, Iñigo; Valencia, A. (Autor de correspondencia); et al.Título: On the inconsistent treatment of gene-protein-reaction rules in context-specific metabolic modelsRevista: BIOINFORMATICSISSN 1367-4803 Vol.36 N° 6 2020 págs. 1986 - 1988
Autores: Voges, J.; Paridaens, T.; Müntefering, F.; et al.Revista: BIOINFORMATICSISSN 1367-4803 2020ResumenMOTIVATION: In an effort to provide a response to the ever-expanding generation of genomic data, the International Organization for Standardization (ISO) is designing a new solution for the representation, compression and management of genomic sequencing data: the MPEG-G standard. This paper discusses the first implementation of an MPEG-G compliant entropy codec: GABAC. GABAC combines proven coding technologies, such as context-adaptive binary arithmetic coding, binarization schemes and transformations, into a straightforward solution for the compression of sequencing data. RESULTS: We demonstrate that GABAC outperforms well-established (entropy) codecs in a significant set of cases and thus can serve as an extension for existing genomic compression solutions, such as CRAM. AVAILABILITY: The GABAC library is written in C++. We also provide a command line application which exercises all features provided by the library. GABAC can be downloaded from https://github.com/mitogen/gabac. SUPPLEMENTARY INFORMATION: Supplementary data, including a complete list of the funding mechanisms and acknowledgements, are available at Bioinformatics online.
Autores: Alvarez, G. D. Y. ; Seroussi, G.; Smircich, P.; et al.Revista: BIOINFORMATICSISSN 1367-4803 Vol.36 N° 16 2020 págs. 4506 - 4507ResumenMotivation: The amount of genomic data generated globally is seeing explosive growth, leading to increasing needs for processing, storage and transmission resources, which motivates the development of efficient compression tools for these data. Work so far has focused mainly on the compression of data generated by short-read technologies. However, nanopore sequencing technologies are rapidly gaining popularity due to the advantages offered by the large increase in the average size of the produced reads, the reduction in their cost and the portability of the sequencing technology. We present ENANO (Encoder for NANOpore), a novel lossless compression algorithm especially designed for nanopore sequencing FASTQ files. Results: The main focus of ENANO is on the compression of the quality scores, as they dominate the size of the compressed file. ENANO offers two modes, Maximum Compression and Fast (default), which trade-off compression efficiency and speed. We tested ENANO, the current state-of-the-art compressor SPRING and the general compressor pigz on several publicly available nanopore datasets. The results show that the proposed algorithm consistently achieves the best compression performance (in both modes) on every considered nanopore dataset, with an average improvement over pigz and SPRING of >24.7% and 6.3%, respectively. In addition, in terms of encoding and decoding speeds, ENANO is 2.9x and 1.7x times faster than SPRING, respectively, with memory consumption up to 0.2 GB.
Autores: Zhang, C.; Ochoa Álvarez, IdoiaRevista: BIOINFORMATICSISSN 1367-4803 Vol.36 N° 8 2020 págs. 2328 - 2336ResumenMOTIVATION: Variants identified by current genomic analysis pipelines contain many incorrectly called variants. These can be potentially eliminated by applying state-of-the-art filtering tools, such as Variant Quality Score Recalibration (VQSR) or Hard Filtering (HF). However, these methods are very user-dependent and fail to run in some cases. We propose VEF, a variant filtering tool based on decision tree ensemble methods that overcomes the main drawbacks of VQSR and HF. Contrary to these methods, we treat filtering as a supervised learning problem, using variant call data with known "true" variants, i.e., gold standard, for training. Once trained, VEF can be directly applied to filter the variants contained in a given VCF file (we consider training and testing VCF files generated with the same tools, as we assume they will share feature characteristics). RESULTS: For the analysis, we used Whole Genome Sequencing (WGS) Human datasets for which the gold standards are available. We show on these data that the proposed filtering tool VEF consistently outperforms VQSR and HF. In addition, we show that VEF generalizes well even when some features have missing values, when the training and testing datasets differ in coverage, and when sequencing pipelines other than GATK are used. Finally, since the training needs to be performed only once, there is a significant saving in running time when compared to VQSR (4 versus 50minutes approximately for filtering the SNPs of a WGS Human
Autores: Meng, Q. X.; Ochoa Álvarez, Idoia; Hernaez Arrazola, MikelTítulo: GPress: a framework for querying general feature format (GFF) files and expression files in a compressed formRevista: BIOINFORMATICSISSN 1367-4803 Vol.36 N° 18 2020 págs. 4810 - 4812ResumenMotivation: Sequencing data are often summarized at different annotation levels for further analysis, generally using the general feature format (GFF) or its descendants, gene transfer format (GTF) and GFF3. Existing utilities for accessing these files, like gffutils and gffread, do not focus on reducing the storage space, significantly increasing it in some cases. We propose GPress, a framework for querying GFF files in a compressed form. GPress can also incorporate and compress expression files from both bulk and single-cell RNA-Seq experiments, supporting simultaneous queries on both the GFF and expression files. In brief, GPress applies transformations to the data which are then compressed with the general lossless compressor BSC. To support queries, GPress compresses the data in blocks and creates several index tables for fast retrieval. Results: We tested GPress on several GFF files of different organisms, and showed that it achieves on average a 61% reduction in size with respect to gzip (the current de facto compressor for GFF files) while being able to retrieve all annotations for a given identifier or a range of coordinates in a few seconds (when run in a common laptop). In contrast, gffutils provides faster retrieval but doubles the size of the GFF files. When additionally linking an expression file, we show that GPress can reduce its size by more than 68% when compared to gzip (for both bulk and single-cell RNA-Seq experiments), while still retrieving the information within seconds. Finally, applying BSC to the data streams generated by GPress instead of to the original file shows a size reduction of more than 44% on average.
Autores: Ferrer-Bonsoms, J. A.; Cassol, I. ; Fernandez-Acin, P. ; et al.Revista: SCIENTIFIC REPORTSISSN 2045-2322 Vol.10 N° 1 2020ResumenThe advent of RNA-seq technologies has switched the paradigm of genetic analysis from a genome to a transcriptome-based perspective. Alternative splicing generates functional diversity in genes, but the precise functions of many individual isoforms are yet to be elucidated. Gene Ontology was developed to annotate gene products according to their biological processes, molecular functions and cellular components. Despite a single gene may have several gene products, most annotations are not isoform-specific and do not distinguish the functions of the different proteins originated from a single gene. Several approaches have tried to automatically annotate ontologies at the isoform level, but this has shown to be a daunting task. We have developed ISOGO (ISOform + GO function imputation), a novel algorithm to predict the function of coding isoforms based on their protein domains and their correlation of expression along 11,373 cancer patients. Combining these two sources of information outperforms previous approaches: it provides an area under precision-recall curve (AUPRC) five times larger than previous attempts and the median AUROC of assigned functions to genes is 0.82. We tested ISOGO predictions on some genes with isoform-specific functions (BRCA1, MADD,VAMP7 and ITSN1) and they were coherent with the literature. Besides, we examined whether the main isoform of each gene -as predicted by APPRIS- was the most likely to have the annotated gene functions and it occurs in 99.4% of the genes. We also evaluated the predictions for isoform-specific functions provided by the CAFA3 challenge and results were also convincing. To make these results available to the scientific community, we have deployed a web application to consult ISOGO predictions (https://biotecnun.unav.es/app/isogo). Initial data, website link, isoform-specific GO function predictions and R code is available at https://gitlab.com/icassol/isogo.
Proyectos desde 2018
Título: bG22 - Desarrollo de métodos diagnósticos y nuevas terapias en la era de la medicina de precisión en cáncer (GV Elkartek Tipo1)Código de expediente: KK-2022-00045Investigador principal: FRANCISCO JAVIER PLANES PEDREÑO.Financiador: GOBIERNO VASCOConvocatoria: Programa ELKARTEK 2022 K1: Proyecto de Investigación Fundamental Colaborativa - Investigación FundamentalFecha de inicio: 14-07-2022Fecha fin:Importe concedido: 121.787,88 €Fondos FEDER: NO
Título: Planes_F_JCI20_SergioPerezCódigo de expediente: SFJC2000I046252XV0Investigador principal: FRANCISCO JAVIER PLANES PEDREÑO.Financiador: AGENCIA ESTATAL DE INVESTIGACIONConvocatoria: 2020 AEI JUAN DE LA CIERVA INCORPORACIONFecha de inicio: 01-01-2022Fecha fin: 31-12-2023Importe concedido: 0Fondos FEDER: NO
Título: BECA Ochoa_I_Ramon y Cajal 2019Código de expediente: RYC2019-028578-IInvestigador principal: IDOIA OCHOA ALVAREZ.Financiador: MINISTERIO DE CIENCIA E INNOVACIÓNConvocatoria: 2019 AEI - MCIU RAMÓN Y CAJALFecha de inicio: 01-05-2021Fecha fin: 28-04-2026Importe concedido: 208.600,00 €Fondos FEDER: NO
Título: Desarrollo y validacion de nuevos algoritmos predictivos de letalidad sintetica en cancerCódigo de expediente: PIBA_2020_1_0055Investigador principal: FRANCISCO JAVIER PLANES PEDREÑO.Financiador: GOBIERNO VASCOConvocatoria: 2019 GV Elkartek 2019 - Fase I. Programa de apoyo a la investigación colaborativa en áreas estratégicasFecha de inicio: 04-11-2020Fecha fin: 30-09-2023Importe concedido: 49.759,00 €Fondos FEDER: NO
Título: Nueva aproximación computacional para predecir letalidad sintética en cáncerCódigo de expediente: PID2019-110344RB-I00Investigador principal: FRANCISCO JAVIER PLANES PEDREÑO, ANGEL RUBIO DIAZ-CORDOVES.Financiador: MINISTERIO DE CIENCIA E INNOVACIÓNConvocatoria: 2019 AEI PROYECTOS I+D+i (incluye Generación del conocimiento y Retos investigación)Fecha de inicio: 01-06-2020Fecha fin: 01-01-2023Importe concedido: 90.750,00 €Fondos FEDER: NO
Título: BECA G.FELLOWS IDOIA OCHOA Atraccion al Talento - Integracion de datos multi-omicos y su aplicacion a muestras hematologicas malignas.Código de expediente: 2020-FELL-000012-01Investigador principal: IDOIA OCHOA ALVAREZ.Financiador: DIPUTACIÓN FORAL DE GIPUZKOAConvocatoria: 2020 DFG Fellows Gipuzkoa de atracción y retención de talentoFecha de inicio: 15-04-2020Fecha fin: 14-04-2021Importe concedido: 50.000,00 €Fondos FEDER: NO
Título: Medicina de Precisión en cáncer: desarollo de herramientas diagnosticas y nuevas terapias.Código de expediente: KK-2020/000008Investigador principal: FRANCISCO JAVIER PLANES PEDREÑO.Financiador: GOBIERNO VASCOConvocatoria: 2020 GV Elkartek -Proyectos de apoyo a la investigacion colaborativa en areas estrategicas.Tipo 1.Fecha de inicio: 01-03-2020Fecha fin: 31-12-2021Importe concedido: 46.053,00 €Fondos FEDER: NO
Título: Early detection and detection:understanding the mechanisms of transformacion an hidden resistance on incurable hematological malignencies.Código de expediente:Investigador principal: ANGEL RUBIO DIAZ-CORDOVESFinanciador: CANCER RESEARCH UKConvocatoria: Seed FundingFecha de inicio: 01-12-2018Fecha fin: 30-11-2023Importe concedido: 270.000,00 €Fondos FEDER: NO
Título: Smart Technologies for personalised nutrition and consumer engagement.Código de expediente: SEP-210501740Investigador principal: FRANCISCO JAVIER PLANES PEDREÑOFinanciador: COMISIÓN EUROPEAConvocatoria: H2020-SFS-2018-1Fecha de inicio: 11-01-2018Fecha fin: 30-09-2022Importe concedido: 200.668,00 €Fondos FEDER: NO