Grupos Investigadores

Líneas de Investigación

  • Ciencia y religión
  • Ciencia y verdad
  • Evolucionismo
  • Naturaleza y persona
  • Orden, complejidad y finalidad
  • Origen del Universo

Palabras Clave

  • Ciencia y religión
  • Epistemología
  • Filosofía de la ciencia
  • Filosofía de la naturaleza
  • Interdisciplinariedad
  • Razón y fe
  • Teología de la naturaleza

Publicaciones Científicas desde 2018

  • Autores: Ahmed, S. P.; Sáez Castresana, Javier; Shahi, M. H. (Autor de correspondencia)
    Revista: CELLS
    ISSN: 2073-4409 Vol.11 N° 14 2022 págs. 2130
    Resumen
    Central nervous system tumors are a leading cause of cancer-related death in children and adults, with medulloblastoma (MB) and glioblastoma (GBM) being the most prevalent malignant brain tumors, respectively. Despite tremendous breakthroughs in neurosurgery, radiation, and chemotherapeutic techniques, cell heterogeneity and various genetic mutations impacting cell cycle control, cell proliferation, apoptosis, and cell invasion result in unwanted resistance to treatment approaches, with a 5-year survival rate of 70-80% for medulloblastoma, and the median survival time for patients with glioblastoma is only 15 months. Developing new medicines and utilizing combination medications may be viewed as excellent techniques for battling MB and GBM. Circular RNAs (circRNAs) can affect cancer-developing processes such as cell proliferation, cell apoptosis, invasion, and chemoresistance in this regard. As a result, several compounds have been introduced as prospective therapeutic targets in the fight against MB and GBM. The current study aims to elucidate the fundamental molecular and cellular mechanisms underlying the pathogenesis of GBM in conjunction with circRNAs. Several mechanisms were examined in detail, including PI3K/Akt/mTOR signaling, Wnt/-catenin signaling, angiogenic processes, and metastatic pathways, in order to provide a comprehensive knowledge of the involvement of circRNAs in the pathophysiology of MB and GBM.
  • Autores: Herce Fernández, Rubén
    Revista: SCRIPTA THEOLOGICA
    ISSN: 0036-9764 Vol.54 N° 2 2022 págs. 527 - 530
  • Autores: Herce Fernández, Rubén
    Revista: SCRIPTA THEOLOGICA
    ISSN: 0036-9764 Vol.54 N° 2 2022 págs. 531 - 535
  • Autores: Sánchez Cañizares, Javier
    Revista: BEHAVIORAL AND BRAIN SCIENCES
    ISSN: 0140-525X Vol.45 2022 págs. e207
    Resumen
    Bruineberg et al. underestimate the ontological weight of Markov blankets as actual boundaries of systems and lean toward an instrumentalist understanding thereof. Yet Markov blankets need not be deemed mere tools. Determining their reality depends on the fundamental problem of distinguishing between system and environment in physics, which, in turn, demands a metaphysical bedrock backed by a realist stance on science.
  • Autores: Pardo Caballos, Antonio (Autor de correspondencia)
    Revista: CUADERNOS DE BIOETICA
    ISSN: 1132-1989 Vol.33 N° 107 2022 págs. 125 - 127
  • Autores: Montoya Camacho, Jorge Martín
    Revista: SCIENTIA ET FIDES
    ISSN: 2300-7648 Vol.10 N° 1 2022 págs. 281 - 291
    Resumen
    ¿Puede ser comprendida la moralidad aisladamente de los órdenes sociales, culturales, políticos y económicos en los que surge y se desarrolla? ¿El interés intelectual por la moralidad de nuestro tiempo requiere algo más que el análisis de teorías éticas? Las respuestas de Alasdair MacIntyre a estas preguntas se muestran a través del trabajo de toda una vida, en la que ha desarrollado un análisis ético de la Modernidad. El libro «Valoración ética de la modernidad según Alasdair MacIntyre», de Hernando José Bello Rodríguez y José Manuel Giménez Amaya, expone el desarrollo de tal análisis, llevado a cabo por el filósofo escocés en el marco de sus ideas que van desde la publicación de su obra After Virtue, hasta la reciente aparición de Ethics in Conflicts of Modernity.
  • Autores: Herce Fernández, Rubén
    Revista: PENSAMIENTO
    ISSN: 0031-4749 Vol.78 N° 298 2022 págs. 337 - 350
    Resumen
    Roger Penrose formuló en 1989 un argumento contra la IA. Dicho argumento concluye que la explicación científico-matemática de la realidad es más amplia que la meramente computacional, porque existen ciertos aspectos de la realidad no-computables. Este artículo analiza dicho argumento y la discusión al respecto, para concluir que el tipo de argumento que quiere desarrollar Penrose está viciado de raíz, lo que impide llegar a las conclusiones deseadas. A la vez se sostiene la validez filosófica de sus conclusiones y se apunta a la idea de no-localidad como consistente al hablar sobre la conciencia.
  • Autores: Montoya Camacho, Jorge Martín; Giménez Amaya, José Manuel
    Revista: CUADERNOS DE PENSAMIENTO
    ISSN: 0214-0284 Vol.1 N° 35 2022 págs. 71 - 104
    Resumen
    Una de las características principales del desarrollo de la modernidad ha sido el encubrimiento de los fines naturales de la técnica. En este artículo profundizamos en esa desnaturalización, que ha hecho de la tecnología un elemento susceptible de estar al servicio de un poder deshumanizante. Sostenemos que este proceso ha llevado al oscurecimiento de una visión natural del ser humano que evita fundamentar la integración de su vida con el bien de la sociedad. Por tanto, se percibe en la actualidad un desgajamiento entre los fines naturales de la humanidad y los elementos técnicos que solo puede ser corregido por el potenciamiento de los vínculos dentro de una comunidad. Con este marco, analizamos los problemas que derivan del planteamiento moderno desde las perspectivas antropológica, ética y sociológica.
  • Autores: Sánchez Cañizares, Javier
    Revista: FOUNDATIONS OF SCIENCE
    ISSN: 1572-8471 Vol.27 N° 1 2022 págs. 77 - 94
    Resumen
    Integrated Information Theory (IIT) stands out as one of the most promising theories for dealing with the hard problem of consciousness. Founded on five axioms derived from phenomenology, IIT seeks for the physical substrate of consciousness that complies with such axioms according to the criterion of maximally integrated information (phi). Eventually, IIT identifies phenomenal consciousness with maximal phi or, what is the same thing, with the strongest cause-effect power in the system. Among the scholars critical of this theory, some point to the so-called Intrinsicality Problem (IP), namely that consciousness cannot be an intrinsic property of the system because maximal phi crucially depends on the possible existence of bigger values of phi if the initial system is appropriately linked to or embedded in larger systems. Although proposals in the recent literature aim to solve the IP by going beyond reductionism and physicalism, none of them tackle the real issue, i.e., the insufficiency of IIT's causal-metaphysical structure. This papers endeavors to provide a solution to the IP in IIT within a hylomorphist ontology that includes formal causation. Complementing IIT with formal causation provides the theory with a criterion of individuation that solves the IP and, by relaxing identification between maximal phi and consciousness, it lends a more robust metaphysical structure. To wit, maximal phi is a necessary but not sufficient condition for the existence of consciousness.
  • Autores: Pardo Caballos, Antonio (Autor de correspondencia)
    Revista: CUADERNOS DE BIOETICA
    ISSN: 1132-1989 Vol.33 N° 109 2022 págs. 249 - 262
    Resumen
    This paper explains basic ideas of Gonzalo Herranz on research ethics, in general and on human beings, obtained from the study of the fragmentary material that has been preserved (drafts and class outlines). Among other ideas, I present his thoughts on the ethical foundations of the researcher's actions: the target of the researcher, the active and passive duty to investigate, the freedom of research and the peculiarities of the relationship between the researcher and the subject of research/patient.
  • Autores: Sánchez Cañizares, Javier (Autor de correspondencia)
    Revista: JOURNAL OF CONSCIOUSNESS STUDIES
    ISSN: 1355-8250 Vol.29 N° 1-2 2022 págs. 56 - 78
    Resumen
    Integrated information theory (IIT) stands out as one of the most promising approaches to scientifically understand the emergence of consciousness. Even if it borrows from the phenomenology of consciousness to derive its axiomatic formulation, IIT does not initially adhere to any particular ontological position. However, its founder leans towards panpsychism. More recently, Owen has studied the pros and cons of different ontologies as a metaphysical basis for IIT, defending a hylomorphic stance where en-grounding, en-forming relations gain the upper hand in the causal narrative. This paper aims at (1) complementing Owen's work by invoking additional arguments against physicalist IIT, both reductive and non-reductive; and (2) improving Owen's characterization of non-physicalist causality through a `nested' version of hylomorphism that avoids the combination problem of panpsychism.
  • Autores: Sánchez Cañizares, Javier (Autor de correspondencia)
    Revista: EUROPEAN JOURNAL OF SCIENCE AND THEOLOGY
    ISSN: 1841-0464 Vol.18 N° 6 2022 págs. 113 - 128
    Resumen
    Current discussions on the philosophy of Nature hinge on the concept of emergence. Such a concept has long succeeded in the Life sciences and is increasingly receiving the focus of Physics and Philosophy of Physics alike. Remarkably enough, even for basic scientists, there is no agreement on whether emergence should be considered fundamental (ontological) or just an elegant and more straightforward (epistemic) way of referring to complex arrangements of basic stuff. In this paper: (1) I evince said disagreement by confronting two distinguished approaches, namely Bishop and Ellis¿s, and Sean Carroll¿s. (2) I intend to move beyond the loggerheads by supporting ontological emergence as a widespread feature in Nature. I invoke Penrose¿s argument of functional freedom as an epistemic hint for ontological emergence, i.e. the necessary recourse to additional - apparently non-fundamental - criteria to justify the coarse-graining of finer, lower levels into coarser, higher levels in Nature. Said move, if understood in keeping with a minimum scientific realism, points towards a different kind of causality at work in the universe, classically referred to as formal causation. (3) Once ontological emergence is naturalized, one can frame the emergence of immaterial knowledge as an ontological apex - dubbed ultimate emergence - that reverses the trend of coarse-graining.
  • Autores: Sáez Castresana, Javier (Autor de correspondencia)
    Revista: OPEN JOURNAL OF PHILOSOPHY
    ISSN: 2163-9434 Vol.12 N° 1 2022 págs. 21 - 28
    Resumen
    Boredom is a characteristic of today's society. At the individual level and at the social level, the Western countries suffer from boredom. There are extrinsic and intrinsic causes that can lead to boredom. In general, the state of boredom is reached when there are no problems to solve, when the profession does not demand our actions, or when we feel disappointed in realizing that the achievements of life do not give us sustained satisfaction over time. Boredom, especially if it becomes chronic, can be considered a negative thing. But it can also have something positive. The silence, stillness and inaction that define boredom are also characteristics that define the initial state of the person before meditation. This study aims to reflect the possibility of getting out of boredom through meditation. We can abandon boredom if we start a path of personal growth through increasing attention and perception; coming out of ourselves, leaving our own reflections and thoughts, reaching personal emptying and a voluntary impoverishment of our exteriority, which opens the door to us to encounter with being.
  • Autores: Moros Claramunt, Enrique
    Revista: SCRIPTA THEOLOGICA
    ISSN: 0036-9764 Vol.53 N° 1 2021 págs. 239 - 240
  • Autores: Moros Claramunt, Enrique
    Revista: SCRIPTA THEOLOGICA
    ISSN: 0036-9764 Vol.53 N° 1 2021 págs. 240 - 242
  • Autores: Sáez Castresana, Javier (Autor de correspondencia); Meléndez, B.
    Revista: CELLS
    ISSN: 2073-4409 Vol.10 N° 6 2021 págs. 1456
  • Autores: Sánchez Cañizares, Javier
    Revista: THE CONVERSATION
    ISSN: 2201-5639 2021
    Resumen
    El científico británico utilizó sus investigaciones como un medio para entender la creación divina.
  • Autores: Balbuena Delgado, Jana; Sáez Castresana, Javier (Autor de correspondencia); Petriz, J.
    Revista: JOURNAL OF CARCINOGENESIS & MUTAGENESIS
    ISSN: 2157-2518 Vol.12 N° 3 2021 págs. 1000361
    Resumen
    The objective of this work focuses on determining whether there are tumor cells with the Side Population phenotype in cell lines derived from astrocytomas, and if they are sensitive to hypoxia conditions and to the combination of temozolomide with inhibitors of sonic hedgehog pathway (cyclopamine) and of MGMT (O6 -benzylguanine). Cytometry studies were performed to separate the SP cell fraction in all cell lines. The proportion of SP cells was directly proportional to the degree of malignancy of the astrocytoma. The cells showed characteristics of tumor stem cells, such as a greater capacity for self-renewal, and constituted an independent or partially overlapping population with the population of CD133+ cancer stem cells. SP cells were highly resistant to temozolomide, while tumor cells that did not display tumor stem cell properties appeared to be more sensitive. The sonic hedgehog pathway caused resistance to temozolomide, but its inhibition with cyclopamine increased the cytotoxic effects of temozolomide, preferentially in populations not enriched for tumor stem cells of the Side Population. Chemoresistance was often independent of MGMT expression. O6 -benzylguanine was not always capable of increasing the sensitivity to temozolomide in tumor stem cells of the Side Population and in hypoxia.
  • Autores: Fresneda, S. (Autor de correspondencia); Moros Claramunt, Enrique (Autor de correspondencia)
    Revista: STUDIA POLIANA. REVISTA SOBRE EL PENSAMIENTO DE LEONARDO POLO
    ISSN: 1139-6660 N° 23 2021 págs. 151 - 175
    Resumen
    La educación tiene un objetivo principal según las principales regulaciones educativas estatales e internacionales: la consecución de una serie de competencias. Aunque quepa pensar de competencias sociales, cívicas o éticas, la idea central de esta perspectiva es que la educación debe servir en primer lugar para el desempeño de una profesión, que definirá el éxito social de los educandos. El objetivo principal de este artículo es cuestionar filosóficamente la validez de ese objetivo. Sostenemos que la adquisición de competencias debe permanecer, pero basarse y quedar supeditada a la adquisición de las virtudes. Esta respuesta remite al pensamiento de Leonardo Polo y permite una comprensión de la educación basada en su cultivo.
  • Autores: Moros Claramunt, Enrique (Autor de correspondencia)
    Revista: SCIENTIA ET FIDES
    ISSN: 2300-7648 Vol.9 N° 2 2021 págs. 249 - 258
    Resumen
    Jose Cobo maintains that the worldview of contemporary man does not allow him to believe in the sense that the first Christians believed. And he argues that the main cause of that vision has been the development of empirical science. Here I argue that in reality the cause can best be described as an anthropological error, which carries with it a metaphysical deficit. On the other hand, we rectify certain intellectual resources with which we intend to get out of this situation.
  • Autores: Moros Claramunt, Enrique
    Revista: SCRIPTA THEOLOGICA
    ISSN: 0036-9764 Vol.52 N° 1 2020 págs. 247 - 249
  • Autores: Pardo Caballos, Antonio (Autor de correspondencia)
    Revista: CUADERNOS DE BIOETICA
    ISSN: 1132-1989 Vol.31 N° 103 2020 págs. 429 - 433
  • Autores: Muntane Sánchez, A.; Moros Claramunt, Enrique
    Revista: CUADERNOS DE NEUROPSICOLOGIA
    ISSN: 0718-4123 Vol.14 N° 1 2020 págs. 103 - 110
    Resumen
    The Human Brain Project is a European brain research initiative for the advancement of neuroscience and to develop technology inspired by brain information. It is possible that the superior functions of the person are explained neurobiologically, although the relevant question still stands. Am I the one who activates your brain or is it the brain that activates me? An integral understanding of the brain requires a deep vision of this structure and its organization that goes from the genetic study to the whole organ and can not be directed only to a single level. Many authors have highlighted different ideas about brain functioning. Despite this important effort, the question arises whether current neuroscience has the optimal tools to explain in detail the functioning of the human brain. To do this, a series of aspects that are integrated into the so-called mental processes are analyzed. Currently, neuroscience does not give a reason for how our brain works globally. Necessary interdisciplinary work will be essential.
  • Autores: Herce Fernández, Rubén
    Revista: NATURALEZA Y LIBERTAD
    ISSN: 2254-9668 Vol.14 2020 págs. 85 - 97
  • Autores: Novo Villaverde, Francisco Javier
    Revista: SCIENTIA ET FIDES
    ISSN: 2300-7648 Vol.8 N° 2 2020 págs. 323 - 349
    Resumen
    In this article, I analyse the texts in which Joseph Ratzinger deals with biological evolution, particularly in the context of the compatibility between faith in creation and acceptance of the theory of evolution. His first writings on the topic, until 1979, contain the most elaborate and deepest theological and philosophical insights, with a defence of the compatibility between faith in creation and the theory of evolution when the boundaries of their respective explanatory frameworks are respected. At the beginning of the 1980s, still at the philosophical level, Ratzinger engages with the work some atheist scientists who try to portray evolution as a "first philosophy". The 1999 lecture at the Sorbonne University marks the beginning of a period in which he criticizes some technical aspects of the theory of evolution, a position that seems to have been prompted by contacts with anti-evolution German intellectuals in the previous years. After the 2006 meeting of the Schulerkreis in Castel Gandolfo, in which his criticism of evolution reaches its climax, his references to the topic were few and he returned to the philosophical ideas expressed in his earlier writings, stressing that the intrinsic rationality and inner logic of the cosmos point to a creating Reason.
  • Autores: Pardo Caballos, Antonio (Autor de correspondencia)
    Revista: CUADERNOS DE BIOETICA
    ISSN: 1132-1989 Vol.31 N° 101 2020 págs. 107 - 111
  • Autores: Giménez Amaya, José Manuel (Autor de correspondencia); Sánchez-Migallon Granados, Sergio
    Revista: SCIENTIA ET FIDES
    ISSN: 2300-7648 Vol.8 N° 1 2020 págs. 97 - 119
    Resumen
    The university that Alasdair MacIntyre defines as liberal is that which rejects the tradition as something pre-modern and with an impediment for the progress, including the pedagogic one. This university model has been extended in all instances, giving priority to the technical education in a pragmatic way. Thus, the global and sapiential vision of the university has been relegated. This last approach is the key for unifying the knowledge and to pass it onto other people and, therefore, to educate and mold intellectually and morally. However, the professionalization of the philosophy and the criteria of the modern liberalism seem to dominate and inspire most universities in the present day. This situation has plainly shown an inability to become aware of their incompetence to properly educate professors and students alike, in a sapiential and moral manner, threfore deceiving themselves with a naive rhetoric.
  • Autores: Cantero, D.; Mollejo, M.; Sepúlveda, J. M.; et al.
    Revista: NEURO-ONCOLOGY ADVANCES
    ISSN: 2632-2498 Vol.2 N° 1 2020 págs. vdz059
    Resumen
    BACKGROUND: Giant cell glioblastoma (gcGBM) is a rare morphological variant of IDH-wildtype (IDHwt) GBM that occurs in young adults and have a slightly better prognosis than "classic" IDHwt GBM. METHODS: We studied 36 GBMs, 14 with a histopathological diagnosis of gcGBM and 22 with a giant cell component. We analyzed the genetic profile of the most frequently mutated genes in gliomas and assessed the tumor mutation load (TML) by gene-targeted next-generation sequencing. We validated our findings using The Cancer Genome Atlas (TCGA) data. RESULTS: p53 was altered by gene mutation or protein overexpression in all cases, while driver IDH1, IDH2, BRAF, or H3F3A mutations were infrequent or absent. Compared to IDHwt GBMs, gcGBMs had a significant higher frequency of TP53, ATRX, RB1, and NF1 mutations, while lower frequency of EGFR amplification, CDKN2A deletion, and TERT promoter mutation. Almost all tumors had low TML values. The high TML observed in only 2 tumors was consistent with POLE and MSH2 mutations. In the histopathological review of TCGA IDHwt, TP53-mutant tumors identified giant cells in 37% of the cases. Considering our series and that of the TCGA, patients with TP53-mutant gcGBMs had better overall survival than those with TP53wt GBMs (log-rank test, P < .002). CONCLUSIONS: gcGBMs have molecular features that contrast to "classic" IDHwt GBMs: unusually frequent ATRX mutations and few EGFR amplifications and CDKN2A deletions,...
  • Autores: Murillo Gómez, José Ignacio
    Revista: PER LA FILOSOFIA
    ISSN: 0394-4131 Vol.37 N° 108 2020 págs. 85 - 92
    Resumen
    Leonardo Polo¿s philosophical proposal rests on the discovery of a threat of ignorance inherent in human knowledge: from the beginning, our thought presents reality in an objective way that is independent of its active character. Nevertheless, human intelligence can go beyond this limitation if it detects it in such conditions that it can abandon it. In this way, Polo thinks he can continue the classic philosophy by intensifying the consideration of being as a radical activity and expanding the transcendental order so that it includes freedom. This latter purpose certainly implies resuming modern inspiration but also rectifying it. Created freedom no longer appears as an unfounded foundation but as a different sense of being created, which is characterized by inexhaustible novelty and co-existence.
  • Autores: Sáez Castresana, Javier (Autor de correspondencia)
    Revista: OPEN JOURNAL OF PHILOSOPHY
    ISSN: 2163-9434 Vol.10 N° 4 2020 págs. 539 - 554
    Resumen
    Being a professor at university demands thinking about vocation along life. And not only about ones¿ vocation but also about others¿. Vocation for teaching, vocation for learning, vocation for science¿ Vocation is so important that merits a philosophical approach. Following one¿s own vocation is perhaps the most important task everyone has to do in one¿s own life. Following the dictates of personal vocation is without a doubt guarantor of a full, authentic life. And, on the contrary, not following the personal vocation can be one of the reasons for living a life without meaning. Personal vocation as a task, according to Julián Marías¿ philosophy, is introduced in this work, together with the concept of enthusiasm immersed into the vocational pathway. Vocation among university professors seems to be in danger in the global world. Possible causes for it are analyzed.
  • Autores: Bernácer María, Javier (Autor de correspondencia)
    Revista: ANUARIO FILOSOFICO
    ISSN: 0066-5215 Vol.52 N° 3 2019 págs. 650 - 653
  • Autores: Sánchez Cañizares, Javier
    Revista: ZYGON
    ISSN: 0591-2385 Vol.54 N° 2 2019 págs. 543 - 545
    Resumen
    Reseña de Rovelli, Carlo. The Order of Time. Editor: New York, NY: Riverhead Books, 2018.
  • Autores: Sánchez Cañizares, Javier
    Revista: SCRIPTA THEOLOGICA
    ISSN: 0036-9764 Vol.51 N° 1 2019 págs. 268 - 270
    Resumen
    Reseña de Hernando José BELLO RODRÍGUEZ y José Manuel GIMÉNEZ AMAYA, Valoración ética de la modernidad según Alasdair MacIntyre, Pamplona: Eunsa («Astrolabio, Serie Antropología y Ética»), 2018, 208 pp., 11 x 18, ISBN 978-84-313-3284-6.
  • Autores: Sánchez Cañizares, Javier
    Revista: ACTA PHILOSOPHICA
    ISSN: 1121-2179 Vol.28 N° 2 2019 págs. 375 - 378
  • Autores: Moros Claramunt, Enrique (Autor de correspondencia)
    Revista: ANUARIO FILOSOFICO
    ISSN: 0066-5215 Vol.52 N° 3 2019 págs. 623 - 626
  • Autores: Eder-Azanza, L.; Hurtado Rudi, Cristina; Navarro-Herrera, D.; et al.
    Revista: MOLECULAR AND CLINICAL ONCOLOGY
    ISSN: 2049-9450 Vol.10 N° 6 2019 págs. 639 - 643
    Resumen
    In recent years it has been shown that the causes of chronic myeloproliferative neoplasms (MPNs) are more complex than a simple signaling aberration and many other mutated genes affecting different cell processes have been described. For instance, mutations in genes encoding epigenetic regulators are more frequent than expected. One of the latest genes described as mutated is SET binding protein 1 (SETBP1). In silico tools have revealed that there are several human SETBP1 paralogous to nuclear receptor binding SET domain protein 1 (NSD1), NSD2 and NSD3, for example, which are also involved in the development of other hematological malignancies. Therefore, the present study analyzed the mutational status of NSD1, NSD2, NSD3 and SETBP1 in BCR-ABL1 negative MPNs with or without Janus kinase 2 (JAK2) p.V617F mutation. The present study revealed that the NSD genes are not frequently mutated in MPNs. However, a novel SETBP1 mutation was identified in a patient with p.V617F JAK2 positive primary myelofibrosis. These results provide further insight into the genetic complexity of MPNs.
  • Autores: Herce Fernández, Rubén (Autor de correspondencia)
    Revista: SCIENTIA ET FIDES
    ISSN: 2300-7648 Vol.7 N° 2 2019 págs. 165 - 170
    Resumen
    Throughout history, human beings have worked on their personal enhancement. Not only improving the living conditions, but also trying to improve the moral behavior of people, usually through education. The Transhumanist proposal of moral enhancement promises to make us better and understands it as a duty, also because of the ethical challenges that present to us. In the following article we explore if that is possible and to what extent, taking into account that humans are agents.
  • Autores: Tayyab, M.; Shahi, M. H. (Autor de correspondencia); Farheen, S.; et al.
    Revista: JOURNAL OF NEUROSCIENCE RESEARCH
    ISSN: 0360-4012 Vol.96 N° 1 2018 págs. 53 - 62
    Resumen
    There are various theories to explain the pathophysiology of depression and support its diagnosis and treatment. The roles of monoamines, brain-derived neurotrophic factor (BDNF), and Wnt signaling are well researched, but sonic hedgehog (Shh) signaling and its downstream transcription factor Gli1 are not well studied in depression. Shh signaling plays a fundamental role in embryonic development and adult hippocampal neurogenesis and also involved in the growth of cancer. In this article, we summarize the evidence for the Shh signaling pathway in depression and the potential crosstalk of Shh with Wnt and BDNF. Antidepressants are known to upregulate the adult hippocampal neurogenesis to treat depression. Shh plays an important role in adult hippocampal neurogenesis, and its downstream signaling components regulate the synthesis of Wnt proteins. Moreover, the expression of Gli1 and Smo is downregulated in depression. BDNF and Wnt signaling are also regulated by various available antidepressants, so there is the possibility that Shh may be involved in the pathophysiology of depression. Therefore, the crosstalk between the Shh, Wnt, and BDNF signaling pathways is being discussed to identify the potential targets. Specifically, the potential role of the Shh signaling pathway in depression is explored as a new target for better therapies for depression.
  • Autores: Pardo Caballos, Antonio (Autor de correspondencia)
    Revista: CUADERNOS DE BIOETICA
    ISSN: 1132-1989 Vol.29 N° 97 2018 págs. 295 - 299
  • Autores: Sánchez Cañizares, Javier
    Revista: FORUM (ROMA. 2015)
    ISSN: 2498-9746 Vol.4 2018 págs. 103 - 122
    Resumen
    Thermodynamics developed as a new branch of physics in the 19th century helping to go beyond a purely mechanistic understanding of nature. Among its founding fathers, it is William Thomson (Lord Kelvin) who offers a most promising perspective in order to highlight the influence of religious views in the improvement of science. In this article, I will focus on the controversy about the age of the Earth—which confronted Kelvin with many geologists and defenders of the theory of evolution—and I will explain the connections between Kelvin’s credo and his scientific attack on uniformitarianism. Kelvin’s contribution, even if ultimately proven wrong, was right in spirit and served the transition from qualitative to quantitative geology.
  • Autores: Cantero, D.; Rodríguez de Lope, A.; Moreno de la Presa, R.; et al.
    Revista: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    ISSN: 0022-3069 Vol.77 N° 8 2018 págs. 710 - 716
    Resumen
    Glioblastoma (GBM) is the most common malignant adult primary brain tumor. Despite its high lethality, a small proportion of patients have a relatively long overall survival (OS). Here we report a study of a series of 74 GBM samples from 29 long-term survivors ([LTS] OS >= 36 months) and 45 non-LTS. Using next-generation sequencing, we analyzed genetic alterations in the genes most frequently altered in gliomas. Approximately 20% of LTS had a mutation in the IDH1 or IDH2 (IDH) genes, denoting the relevance of this molecular prognostic factor. A new molecular group of GBMs harbored alterations in ATRX or DAXX genes in the absence of driver IDH or H3F3A mutations. These patients tended to have a slightly better prognosis, to be younger at diagnosis, and to present frontal or temporal tumors, and, morphologically, to present giant tumor cells. A significant fraction of LTS GBM patients had tumors with 1 or more alterations in the relevant GBM signaling pathways (RTK/PI3K, TP53 and RB1). In these patients, the PDGFRA alteration is suggested to be a favorable molecular factor. Our findings here are relevant for developing future targeted therapies and for identifying molecular prognostic factors in GBM patients.
  • Autores: Montoya Camacho, Jorge Martín
    Revista: SCIENTIA ET FIDES
    ISSN: 2300-7648 Vol.6 N° 2 2018 págs. 183 - 189
    Resumen
    ¿Cuáles son los componentes distintivos del cuerpo humano que permiten identificarlo como un elemento material diferente del resto del mundo físico? ¿Son tales elementos algo meramente funcional, o remiten a otra dimensión que va más allá de la instrumentalidad? Estas son las preguntas que se plantean en el libro ¿Biología y racionalidad. El carácter distintivo del cuerpo humano¿ de José Ángel Lombo y José Manuel Giménez Amaya. Partiendo desde la perspectiva filosófica, los autores buscan clarificar estas cuestiones ofreciendo un marco conceptual interdisciplinar que remite en todo momento a la unidad de la persona humana.
  • Autores: Pardo Caballos, Antonio
    Libro: Qué aporta la muerte a la vida: perspectiva interdisciplinar
    ISSN: 978-84-17892-37-1 2022 págs. 101 - 113
  • Autores: Herce Fernández, Rubén
    Libro: La cosmovisión de los grandes científicos de la Ilustración: convicciones éticas, políticas, filosóficas o religiosas de los protagonistas de la ciencia en el siglo XVIII
    ISSN: 978-84-309-8454-1 2022 págs. 399 - 410
  • Autores: Giménez Amaya, José Manuel; Lombo, J. A.
    Libro: Cuarenta años de After virtue de Alasdair Macintyre: relecturas iberoamericanas
    ISSN: 978-84-1122-298-3 2022 págs. 105 - 114
  • Autores: Sánchez Cañizares, Javier
    Libro: Ciencia y filosofía: estudios en homenaje a Juan Arana
    ISSN: 978-84-123136-6-6 Vol.II 2021 págs. 491 - 499
  • Autores: Collado González, Santiago
    Libro: Ciencia y filosofía: estudios en homenaje a Juan Arana
    ISSN: 978-84-123136-5-9 Vol.I 2021 págs. 115 - 135
    Resumen
    En el capítulo se analiza una de las nociones propuestas por Juan Arana para la epistemología que denomina "Epistemología del riesgo". Se explica la noción y se pone en relación con la tradición filosófica realista con la que se ve continuidad.
  • Autores: Murillo Gómez, José Ignacio
    Libro: Ciencia y filosofía: estudios en homenaje a Juan Arana
    ISSN: 978-84-123136-5-9 (v. 1) Vol.I 2021 págs. 427 - 437
  • Autores: Sánchez Cañizares, Javier
    Libro: Providencia, libertad y mal: Estudios de teología filosófica analítica
    ISSN: 978-84-1369-209-8 2021 págs. 157 - 169
  • Autores: Herce Fernández, Rubén
    Libro: La cosmovisión de los grandes científicos del siglo XIX: convicciones éticas, políticas, filosóficas o religiosas de los protagonistas del siglo de la ciencia
    ISSN: 978-84-309-8208-0 2021 págs. 119 - 128
  • Autores: Sánchez Cañizares, Javier
    Libro: La cosmovisión de los grandes científicos del siglo XIX. Convicciones éticas, políticas, filosóficas o religiosas de los protagonistas del siglo de la ciencia
    ISSN: 978-84-309-8208-0 2021 págs. 206 - 217
  • Autores: Sánchez Cañizares, Javier
    Título: Prólogo
    Libro: Fe y razón: el nexo entre la fe y la ciencia
    ISSN: 978-84-313-3630-1 2021 págs. 11 - 21
  • Autores: Sánchez Cañizares, Javier
    Libro: Studies in Science and Theology, Volume 17 (2019-2020): Are We Special?
    ISSN: 978-3-00-065699-6 Vol.17 2020 págs. 327 - 343
    Resumen
    Despite the endless efforts of fundamental physics, it is becoming increasingly understood that our most basic scientific theories do not fully determine the existence of complex dynamical systems in nature. The revival of optimization principles can be considered a response to mere bottom-up scientific approaches which posit extremely rare boundary conditions of the universe and ad hoc coarse grainings of degrees of freedom in order to recover the classicality of the observed world. In this paper, after making the case for the insurmountable obstacles confronting basic physical theories and obtaining some hints for a possible way out, we briefly review some of the currently most promising optimization procedures trying to explain the emergence of the classical world and, more specifically, of life and consciousness. We claim that all such procedures aim at and make room for new optimizing principles in which value and teleology are fundamental concepts for understanding the self-constitution of complex dynamical systems
  • Autores: Herce Fernández, Rubén
    Libro: III Diálogo entre las ciencias, la filosofía y la teología
    ISSN: 978-84-18360-41-1 Vol.2 2020 págs. 277-286
  • Autores: Sánchez Cañizares, Javier
    Libro: La cosmovisión de los grandes científicos del siglo XX. Convicciones éticas, políticas, filosóficas o religiosas de los protagonistas de las revoluciones científicas contemporáneas
    ISSN: 9788430979073 N° X 2020 págs. 149 - 159
  • Autores: Herce Fernández, Rubén
    Libro: La cosmovisión de los grandes científicos del siglo XX
    ISSN: 978-8430979073 2020 págs. 59 - 69
  • Autores: Murillo Gómez, José Ignacio
    Libro: La cosmovisión de los grandes científicos
    ISSN: 978-84-309-7907-3 2020 págs. 492 - 502
  • Autores: Sánchez Cañizares, Javier
    Libro: III Diálogo entre las ciencias, la filosofía y la teología. III Congreso Razón Abierta. 19-21 de septiembre de 2019
    ISSN: 978-84-18360-37-4 Vol.I 2020 págs. 103 - 114
  • Autores: Herce Fernández, Rubén
    Libro: La cosmovisión de los grandes científicos del siglo XX
    ISSN: 978-8430979073 2020 págs. 70 - 82
  • Autores: Sánchez Cañizares, Javier
    Libro: Diálogos entre las ciencias, la filosofía y la teología. II Congreso Razón Abierta
    ISSN: 978-84-17641-58-0 2019 págs. 57 - 72
  • Autores: Herce Fernández, Rubén
    Libro: ¿Quiénes somos? Cuestiones en torno al ser humano
    ISSN: 9788431332853 2018 págs. 38 - 42

Proyectos desde 2018

  • Título: Providencia y libertad en los modelos del teísmo clásico y del teísmo analítico
    Código de expediente: PID2021-122633NB-I00
    Investigador principal: AGUSTIN IGNACIO ECHAVARRIA ANAVITARTE, JEAN-BAPTISTE FRANCOIS MARIE GUILLON .
    Financiador: AGENCIA ESTATAL DE INVESTIGACION
    Convocatoria: FIMA 2021 MCIU AEI GENERACION CONOCIMIENTO
    Fecha de inicio: 01-09-2022
    Fecha fin: 31-08-2025
    Importe concedido: 41.382,00€
    Otros fondos: Fondos FEDER
  • Título: Descifrando vulnerabilidades en el microambiente tumoral de los linfomas difusos de células B grandes
    Código de expediente: PID2020-112994RB-I00
    Investigador principal: SERGIO ROA GOMEZ.
    Financiador: AGENCIA ESTATAL DE INVESTIGACION
    Convocatoria: 2020 AEI PROYECTOS I+D+i (incluye Generación del conocimiento y Retos investigación)
    Fecha de inicio: 01-01-2019
    Fecha fin: 30-08-2024
    Importe concedido: 220.946,00€
    Otros fondos: -
  • Título: Devaluación en la toma de decisiones en adultos con TDAH: asociación con estilos de vida y efecto de la medicación
    Código de expediente: PSI2017-86763-P
    Investigador principal: JAVIER BERNACER MARIA, GONZALO ARRONDO OSTIZ.
    Financiador: MINISTERIO DE CIENCIA E INNOVACIÓN
    Convocatoria: 2017 MINECO EXCELENCIA
    Fecha de inicio: 01-01-2018
    Fecha fin: 30-09-2021
    Importe concedido: 54.813,00€
    Otros fondos: Fondos FEDER
  • Título: El problema del mal. De Leibniz a la filosofía analítica de la religión
    Código de expediente: FFI2017-84559-P
    Investigador principal: AGUSTIN IGNACIO ECHAVARRIA ANAVITARTE.
    Financiador: MINISTERIO DE CIENCIA E INNOVACIÓN
    Convocatoria: 2017 MINECO EXCELENCIA
    Fecha de inicio: 01-01-2018
    Fecha fin: 30-09-2021
    Importe concedido: 23.595,00€
    Otros fondos: Fondos FEDER
  • Título: Adicción, personalidad y tolerancia a la frustración: un estudio neuropsicológico en sujetos adscritos a Proyecto Hombre
    Código de expediente: 2016/057
    Investigador principal: FRANCISCO JUAN GUELL PELAYO.
    Financiador: MINISTERIO DE SANIDAD, SERVICIOS SOCIALES E IGUALDAD
    Convocatoria: 2016 DROGODEPENDENCIA
    Fecha de inicio: 01-01-2017
    Fecha fin: 31-12-2020
    Importe concedido: 42.683,00€
    Otros fondos: -
  • Título: Templeton Cañizares
    Código de expediente: IP620214001
    Investigador principal: JAVIER SANCHEZ CAÑIZARES
    Financiador: TEMPLETON FOUNDATION
    Convocatoria: JTF Small Grant 2018
    Fecha de inicio: 01-09-2018
    Fecha fin: 31-05-2021
    Importe concedido: 162.393,00€
    Otros fondos: -
  • Título: Nuevos mecanismos oncogenicos
    Investigador principal: JOSE LUIS VIZMANOS PEREZ
    Financiador: UNIVERSIDAD DE NAVARRA
    Convocatoria: 2020 Convocatoria PIUNA, 2021 Convocatoria PIUNA
    Fecha de inicio: 01-09-2020
    Fecha fin: 31-08-2022
    Importe concedido: 19.500,00€
  • Título: Moduladores epigenéticos y promotores del cilio primario como nuevos agentes terapéuticos contra el glioblastoma
    Investigador principal: FRANCISCO JAVIER SAEZ CASTRESANA
    Financiador: UNIVERSIDAD DE NAVARRA
    Convocatoria: 2020 Convocatoria PIUNA, 2019 Convocatoria PIUNA, 2018 Convocatoria PIUNA
    Fecha de inicio: 01-09-2018
    Fecha fin: 31-08-2021
    Importe concedido: 35.000,00€