Grupos Investigadores

Líneas de Investigación

  • Potenciación cognitiva farmacológica en esquizofrenia.
  • Farmacogenética en psiquiatría. Depresión unipolar y bipolar.
  • Circuitos cerebrales de la temporalidad y el cambio en la esquizofrenia y otras psicosis.

Palabras Clave

  • Redes cerebrales
  • Psicopatología
  • Psicopatología
  • Neuroimagen
  • Genética
  • Esquizofrenia
  • Cognición

Publicaciones Científicas desde 2018

  • Autores: Molendijk, M. L. (Autor de correspondencia); Molero Santos, Patricio; Thomas-Odenthal, F.; et al.
    Revista: MOLECULAR PSYCHIATRY
    ISSN 1359-4184 Vol.27 N° 2 2022 págs. 776 - 777
  • Autores: Díaz, M.; Martín-Vivar, M. (Autor de correspondencia); Pla Vidal, Jorge; et al.
    Revista: PSICOSOMÁTICA Y PSIQUIATRÍA
    ISSN 2565-0564 N° 18 2021 págs. 14 - 24
    Resumen
    Introducción: El envejecimiento es un proceso activo en la persona que, además de la salud, abarca otros aspectos. Entre los más importantes se engloban el ajuste físico, el funcionamiento neurocognitivo, el afecto positivo y la implicación social. Durante el envejecimiento, es importante que la persona siga siendo protagonista, fomentándose derechos como la dignidad, privacidad y autodeterminación. De esta forma, si vive en una residencia, el entorno que le rodea se convierte en aspectos fundamentales a tener en cuenta. Método: Por todo ello, esta revisión narrativa busca identificar y analizar la influencia de diferentes variables del entorno residencial en la salud y en el proceso de envejecimiento. Resultados y conclusión: Los trabajos revisados confirman que la existencia de jardines, salones de actos y espacios para diferentes actividades lúdicas, culturales y espirituales fomentan el envejecimiento activo y podrían considerarse factores de protección para la salud de los residentes.
  • Autores: Garcés, M. S.; Alustiza Quintana, Irene Lucila (Autor de correspondencia); Albajes-Eizagirre, A.; et al.
    Revista: FRONTIERS IN PSYCHIATRY
    ISSN 1664-0640 Vol.12 2021 págs. 786113
    Resumen
    Recent functional neuroimaging studies suggest that the brain networks responsible for time processing are involved during other cognitive processes, leading to a hypothesis that time-related processing is needed to perform a range of tasks across various cognitive functions. To examine this hypothesis, we analyze whether, in healthy subjects, the brain structures activated or deactivated during performance of timing and oddball-detection type tasks coincide. To this end, we conducted two independent signed differential mapping (SDM) meta-analyses of functional magnetic resonance imaging (fMRI) studies assessing the cerebral generators of the responses elicited by tasks based on timing and oddball-detection paradigms. Finally, we undertook a multimodal meta-analysis to detect brain regions common to the findings of the two previous meta-analyses. We found that healthy subjects showed significant activation in cortical areas related to timing and salience networks. The patterns of activation and deactivation corresponding to each task type partially coincided. We hypothesize that there exists a time and change-detection network that serves as a common underlying resource used in a broad range of cognitive processes.
  • Autores: Fortea, L.; Solanes, A.; Pomarol-Clotet, E.; et al.
    Revista: COLORADO MUNICIPALITIES
    ISSN 0010-1664 Vol.12 2021 págs. 642763
    Resumen
    Background: The coronavirus disease 2019 (COVID-19) pandemic and lockdown might increase anxiety and depressive symptoms in most individuals. Health bodies recommend several coping behaviors to protect against such symptoms, but evidence on the relationship between these behaviors and symptoms mostly comes from cross-sectional studies in convenience samples. We will conduct a prospective longitudinal study of the associations between coping behaviors and subsequent anxiety and depressive symptoms during the COVID-19 pandemic in a representative sample of the Spanish general adult population. Methods: We will recruit 1,000 adult participants from all autonomous communities of Spain and with sex, age, and urbanicity distributions similar to those of their populations and assess anxiety and depressive symptoms and coping behaviors using fortnightly questionnaires and real-time methods (ecological momentary assessments) for 1 year. The fortnightly questionnaires will inquire about anxiety and depressive symptoms [General Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9)] and the frequency of 10 potential coping behaviors (e.g., follow a routine) during the past 2 weeks. In addition, we will collect several variables that could confound or moderate these associations. These will include subjective well-being [International Positive and Negative Affect Schedule Short Form (I-PANAS-SF) and Satisfaction with Life Scale (SWLS)], ...
  • Autores: Álvarez de Mon González, Miguel (Autor de correspondencia); Guillén-Aguinaga, S.; Pereira Sánchez, Víctor; et al.
    Revista: JOURNAL OF CLINICAL MEDICINE
    ISSN 2077-0383 Vol.10 N° 13 2021 págs. 2859
    Resumen
    Background: We analyzed the relationship between the prevalence of schizophrenia and the season of birth and gestation during a period of an influenza pandemic. Methods: Cross-sectional analysis of a prospective population-based cohort of 470,942 adults. We fitted multivariant logistic regression models to determine whether the season of birth and birth in an influenza-pandemic year (1957, 1968, 1977) was associated with schizophrenia. Results: 2077 subjects had been diagnosed with schizophrenia. Logistic regression identified a significantly greater prevalence of schizophrenia in men than in women (OR = 1.516, CI 95% = 1.388-1.665); in those born in the winter or spring than in those born in the summer or autumn (OR = 1.112, CI 95% = 1.020-1.212); and in those born in a period of an influenza pandemic (OR = 1.335, CI 95% = 1.199-1.486). The increase in risk was also significant when each influenza pandemic year was analyzed separately. However, neither month of birth nor season of birth, when each of the four were studied individually, were associated with a statistically significant increase in that risk. Conclusions: The winter-spring period and the influenza pandemics are independent risk factors for developing schizophrenia. This study contradicts many previous studies and thus revitalizes a locked debate in understanding the neurodevelopmental hypothesis of this disorder.
  • Autores: Thomas-Odenthal, F. (Autor de correspondencia); Molero Santos, Patricio; van der Does, W.; et al.
    Revista: PLOS ONE
    ISSN 1932-6203 Vol.15 N° 9 2020
    Resumen
    Background The recommendations of experts who write review articles are a critical determinant of the adaptation of new treatments by clinicians. Several types of reviews exist (narrative, systematic, meta-analytic), and some of these are more vulnerable to researcher bias than others. Recently, the interest in nutritional interventions in psychiatry has increased and many experts, who are often active researchers on this topic, have come to strong conclusions about the benefits of a healthy diet on depression. In a young and active field of study, we aimed to investigate whether the strength of an author's conclusion is associated with the type of review article they wrote. Methods Systematic searches were performed in PubMed, Web of Science, Cochrane Database of Systematic Reviews, and Google Scholar for narrative reviews and systematic reviews with and without meta-analyses on the effects of diet on depression (final search date: May 30(th), 2020). Conclusions were extracted from the abstract and discussion section and rated as strong, moderate, or weak by independent raters who were blind to study type. A benchmark on legitimate conclusion strength was based on a GRADE assessment of the highest level of evidence. This systematic review was registered with PROSPERO, number CRD42020141372. Findings 24 narrative reviews, 12 systematic reviews, and 14 meta-analyses were included. In the abstract, 33% of narrative reviews and 8% of systematic reviews came to strong conclusions, whereas no meta-analysis did. Narrative reviews were 8.94 (95% CI: 2.17, 36.84) times more likely to report stronger conclusions in the abstract than systematic reviews with and without meta-analyses. These findings were similar for conclusions in the discussion section. Narrative reviews used 45.6% fewer input studies and were more likely to be written by authors with potential conflicts of interest. A study limitation is the subjective nature of the conclusion classification system despite high inter-rater agreements and its confirmation outside of the review team. Conclusions We have shown that narrative reviews come to stronger conclusions about the benefits of a healthy diet on depression despite inconclusive evidence. This finding empirically underscores the importance of a systematic method for summarizing the evidence of a field of study. Journal editors may want to reconsider publishing narrative reviews before meta-analytic reviews are available.
  • Autores: Viguria Arrieta, Iranzu; Álvarez de Mon González, Miguel (Autor de correspondencia); Llavero Valero, María; et al.
    Revista: JOURNAL OF MEDICAL INTERNET RESEARCH
    ISSN 1438-8871 Vol.22 N° 7 2020
    Resumen
    Background: Health awareness initiatives are frequent but their efficacy is a matter of controversy. We have investigated the effect of the Eating Disorder Awareness Week and Wake Up Weight Watchers campaigns on Twitter. Objective: We aimed to examine whether the Eating Disorder Awareness Week and Wake Up Weight Watchers initiatives increased the volume and dissemination of Twitter conversations related to eating disorders and investigate what content generates the most interest on Twitter. Methods: Over a period of 12 consecutive days in 2018, we collected tweets containing the hashtag #wakeupweightwatchers and hashtags related to Eating Disorder Awareness Week (#eatingdisorderawarenessweek, #eatingdisorderawareness, or #EDAW), with the hashtag #eatingdisorder as a control. The content of each tweet was rated as medical, testimony, help offer, awareness, pro-ana, or anti-ana. We analyzed the number of retweets and favorites generated, as well as the potential reach and impact of the hashtags and the characteristics of contributors. Results: The number of #wakeupweightwatchers tweets was higher than that of Eating Disorder Awareness Week and #eatingdisorder tweets (3900, 2056, and 1057, respectively). The content of tweets was significantly different between the hashtags analyzed (P<.001). Medical content was lower in the awareness campaigns. Awareness and help offer content were lower in #wakeupweightwatchers tweets. Retweet and favorite ratios were highest in #wakeupweightwatchers tweets. Eating Disorder Awareness Week achieved the highest impact, and very influential contributors participated. Conclusions: Both awareness campaigns effectively promoted tweeting about eating disorders. The majority of tweets did not promote any specific preventive or help-seeking behaviors.
  • Autores: Goena Vives, Javier; Garces, M. S.; Alustiza Quintana, Irene Lucila; et al.
    Revista: SCHIZOPHRENIA BULLETIN
    ISSN 0586-7614 Vol.46 N° Supl. 1 2020 págs. S191
  • Autores: Álvarez de Mon González, Miguel; Gomez, A.; Orozco, A.; et al.
    Revista: EUROPEAN PSYCHIATRY
    ISSN 0924-9338 Vol.63 2020 págs. S654 - S654
  • Autores: Alustiza Quintana, Irene Lucila; Garces, M. S. ; Goena Vives, Javier; et al.
    Revista: SCHIZOPHRENIA BULLETIN
    ISSN 0586-7614 Vol.46 N° Supl. 1 2020 págs. S159
  • Autores: Álvarez de Mon González, Miguel; Vidal Adroher, Cristina; Ortuño Sánchez-Pedreño, Felipe
    Revista: MEDICINE (ELSEVIER)
    ISSN 0304-5412 Vol.12 N° 86 2019 págs. 5075 - 5080
    Resumen
    Although antipsychotic drugs are effective against positive psychosis symptoms, their effectiveness is limited against negative ones. Treatment has to be supplemented with non-pharmacological measures (psychoeducation, cognitive rehabilitation, social skills training). One of the greatest challenges is therapeutic adherence, being crucial to achieve a good evolution. The best therapeutic option for treatment-resistant schizophrenia is clozapine.
  • Autores: Álvarez de Mon González, Miguel (Autor de correspondencia); Gomez, A. M.; Orozco, A.; et al.
    Revista: FRONTIERS IN PSYCHIATRY
    ISSN 1664-0640 Vol.10 2019 págs. 812
    Resumen
    Introduction: Major depressive disorder (MDD) patients experience a systemic inflammatory stage. Monocytes play an important role in innate inflammatory responses and may be modulated by bacterial translocation. Our aim was to investigate the subset distribution and function of circulating monocytes, levels of proinflammatory cytokines, gut barrier damage, and bacterial translocation in MDD patients. Methods: Twenty-two MDD patients without concomitant diseases and 14 sex- and age-matched healthy controls were studied. The levels of circulating CD14(++)CD16(-) (classical), CD14(++)CD16(++) (intermediate) and CD14(-)CD16(++) (nonclassical) monocytes and the intracytoplasmic tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, and IL-10 expression in the presence or absence of lipopolysaccharide (LPS) stimulation were analyzed by polychromatic flow cytometry. The serum TNF-alpha, IL-1 beta, IL-6, and IL-10 levels were measured by Luminex. LPS-binding protein (LBP), intestinal fatty acid-binding protein (I-FABP), and zonulin were measured by enzyme-linked immunosorbent assay (ELISA). Results: MDD patients had a significant increase in the frequency of intermediate monocytes and a significant decrease in the frequency of classical monocytes compared to those in the healthy controls. MDD patients had a significantly increased percentage of classical monocytes that expressed IL-1 beta, intermediate monocytes that expressed IL-1 beta and IL6 and nonclassical monocytes that expressed IL-1 beta, and decreased levels of nonclassical monocytes that expressed IL6 compared to those in the healthy controls. MDD patients had significantly increased levels of circulating TNF-alpha, IL-1 beta, LBP, and I-FABP compared to those in the healthy controls. MDD patients with high LBP levels had a significant reduction in the number of circulating monocytes compared to that in the normal-LBP MDD patients, which can be mainly ascribed to a decrease in the number of intermediate and nonclassical monocytes. Conclusions: We have demonstrated that compared to the healthy controls, MDD patients show a marked alteration in circulating monocytes, with an expansion of the intermediate subset with increased frequency of IL-1 beta and IL-6 producing cells. These patients also exhibited a systemic proinflammatory state, which was characterized by the enhanced serum TNF-alpha and IL-1 beta levels compared to those in the healthy controls. Furthermore, MDD patients showed increased LBP and I-FABP levels compared to those in healthy controls, indicating increased bacterial translocation and gut barrier damage.
  • Autores: Gurpegui, D.; Ortuño Sánchez-Pedreño, Felipe; Gurpegui, M. (Autor de correspondencia)
    Revista: JOURNAL OF AFFECTIVE DISORDERS
    ISSN 0165-0327 Vol.243 2019 págs. 494 - 502
    Resumen
    Background: The aim of this naturalistic longitudinal study was to add evidence regarding the potential of Cloninger's temperament traits (novelty seeking, harm avoidance, reward dependence and persistence) for predicting the effect of pharmacological treatment on the rates of therapeutic response and remission. Methods: The study was based on 200 outpatients with unipolar depressive disorders of different severity and course of illness, and extended up to 6 months of follow-up. Patients were assessed in their temperament with the Tridimensional Personality Questionnaire (TPQ) and their condition was classified (in course and severity) according to the International Classification of Diseases, Tenth revision (ICD-10) diagnostic criteria for research. Patients were blindly rated (concerning other predicting variables) on the improved Clinical Global Impression-Severity scale for depression (iCGI-S) at baseline, 6 weeks, 3 months and 6 months. Outcome measures at the last observation carried forward were therapeutic response (reduction of >= 50% in the last iCGIS) and remission (last iCGI-S = 0), which were available for 187 patients. Results: Remission was independently and directly associated with length of follow-up, and inversely with the baseline iCGI-S score and harm avoidance (patients in the high tertile had a 2.7 likelihood of non-remission in comparison with those in the low tertile); persistence was found to have a complex, V-shape relationship with remission. Within a sub-sample of more severe cases (n = 118), having higher harm avoidance scores, a more favorable outcome was associated with higher reward dependence and the non-smoking condition. Limitations: With a naturalistic, non-experimental design, the sample may not be representative of the general population. Conclusions: Temperament traits may help predict outcome in patients treated for depression.
  • Autores: Álvarez de Mon González, Miguel; Vidal Adroher, Cristina; Ortuño Sánchez-Pedreño, Felipe
    Revista: MEDICINE (ELSEVIER)
    ISSN 0304-5412 Vol.12 N° 86 2019 págs. 5023 - 5036
    Resumen
    Psychotic disorders are an heterogeneous group of diseases characterized by a symptomatology related to break with reality. Because its severity, schizophrenia is the most relevant disorder, involving the both subject and his family. Classified as neurodevelopmental disease, whose symptoms appear during pregnancy, which evolves to chronicity, and in which relapses along the life are frequent. In the latest version of the classification of the American Psychiatric Association (DSM-5) all psychotic disorders are classified in the same chapter.
  • Autores: Molero Santos, Patricio
    Revista: EUROPEAN PSYCHIATRY
    ISSN 0924-9338 Vol.56 2019 págs. S616 - S617
  • Autores: Grima, F. G.; Brugos-Larumbe, A.; Guillén Grima, Francisco; et al.
    Revista: EUROPEAN JOURNAL OF PUBLIC HEALTH
    ISSN 1101-1262 Vol.29 N° Supl. 4 2019
  • Autores: Daly, E. J.; Trivedi, M.; Janik, A.; et al.
    Revista: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    ISSN 0924-977X Vol.29 N° Supl. 1 2019 págs. S92 - S92
  • Autores: Popova, V.; Daly, E. J. ; Trivedi, M. ; et al.
    Revista: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    ISSN 0924-977X Vol.29 N° Supl. 1 2019 págs. S35 - S36
  • Autores: Molendijk, M.; Molero Santos, Patricio; Ortuño Sánchez-Pedreño, Felipe; et al.
    Revista: JOURNAL OF AFFECTIVE DISORDERS
    ISSN 0165-0327 Vol.226 2018 págs. 346 - 354
    Resumen
    Background: It has been claimed that the quality of a diet is associated with the incidence of depressive disorders. We sought to investigate the evidence for this claim. Methods: Systematic searches were performed up to March 6th, 2017 in order to identify prospective cohort studies that reported on exposure to dietary patterns or food groups and the incidence of depression/depressive symptoms. Data from 24 independent cohorts (totalling 1,959,217 person-years) were pooled in random-effects meta-analyses. Results: Adherence to a high-quality diet, regardless of type (i.e., healthy/prudent or Mediterranean), was associated with a lower risk of depressive symptoms over time (odds ratios ranged 0.64-0.78 in a linear dose-response fashion [P< 0.01]). A relatively low dietary inflammatory index was also associated with a somewhat lower incidence of depressive symptom (odds ratio = 0.81), although not in a dose-response fashion. Similar associations were found for the consumption of fish and vegetables (odds ratios 0.86 and 0.82 respectively) but not for other high quality food groups (e.g., fruit). Studies that controlled for depression severity at baseline or that used a formal diagnosis as outcome did not yield statistically significant findings. Adherence to low quality diets and food groups was not associated with higher depression incidence. Limitations: Our ability to detect confounders was only limited. Conclusion: There is evidence that a higher quality of a diet is associated with a lower risk for the onset of depressive symptoms, but not all available results are consistent with the hypothesis that diet influences depression risk. Prospective studies that control for relevant confounders such as obesity incidence and randomized controlled prevention trials are needed to increase the validity of findings in this field.
  • Autores: Davalos, D. (Autor de correspondencia); Mioni, G.; Grondin, S.; et al.
    Revista: FRONTIERS IN HUMAN NEUROSCIENCE
    ISSN 1662-5161 Vol.12 2018 págs. 435
  • Autores: Álvarez de Mon González, Miguel; Asunsolo del Barco, A.; Lahera, G .; et al.
    Revista: JOURNAL OF MEDICAL INTERNET RESEARCH
    ISSN 1438-8871 Vol.20 N° 5 2018 págs. e205
    Resumen
    Background: The contents of traditional communication media and new internet social media reflect the interests of society. However, certain barriers and a lack of attention towards mental disorders have been previously observed. Objective: The objective of this study is to measure the relevance of influential American mainstream media outlets for the distribution of psychiatric information and the interest generated in these topics among their Twitter followers. Methods: We investigated tweets generated about mental health conditions and diseases among 15 mainstream general communication media outlets in the United States of America between January 2007 and December 2016. Our study strategy focused on identifying several psychiatric terms of primary interest. The number of retweets generated from the selected tweets was also investigated. As a control, we examined tweets generated about the main causes of death in the United States of America, the main chronic neurological degenerative diseases, and HIV. Results: In total, 13,119 tweets about mental health disorders sent by the American mainstream media outlets were analyzed. The results showed a heterogeneous distribution but preferential accumulation for a select number of conditions. Suicide and gender dysphoria accounted for half of the number of tweets sent. Variability in the number of tweets related to each control disease was also found (5998). The number of tweets sent regarding each different psychiatric or organic disease analyzed was significantly correlated with the number of retweets generated by followers (1,030,974 and 424,813 responses to mental health disorders and organic diseases, respectively). However, the probability of a tweet being retweeted differed significantly among the conditions and diseases analyzed. Furthermore, the retweeted to tweet ratio was significantly higher for psychiatric diseases than for the control diseases (odds ratio 1.11, CI 1.07-1.14; P < .001). Conclusions: American mainstream media outlets and the general public demonstrate a preferential interest for psychiatric diseases on Twitter. The heterogeneous weights given by the media outlets analyzed to the different mental health disorders and conditions are reflected in the responses of Twitter followers.
  • Autores: Alustiza Quintana, Irene Lucila (Autor de correspondencia); Garces, M. S.; Solanes, A.; et al.
    Revista: HELIYON
    ISSN 2405-8440 Vol.4 N° 12 2018 págs. e01004
    Resumen
    Schizophrenia (SZ) is associated with deficits in both temporal and salience processing. The underlying neurological dysfunctions in both processes, which are interrelated and share neuroanatomical bases, remain poorly understood. The principal objective of this study was to elucidate whether there are any brain regions that show abnormal response during timing and oddball tasks in patients with SZ. To this end, we conducted a signed differential mapping (SDM) meta-analysis of functional magnetic resonance imaging (fMRI) studies assessing abnormal responses elicited by tasks based on the oddball paradigm in patients with SZ. We conducted a similar SDM meta-analysis of neuroimaging studies of timing tasks in SZ. Finally, we undertook a multimodal meta-analysis to detect the common findings of the two previous meta-analyses. We found that SZ patients showed hypoactivation in cortical and subcortical areas related to timing. The dysfunction observed during timing tasks partially coincided with deficiencies in change-detection functions (particularly in the case of preattentional processing in the mismatch negativity response). We hypothesize that a dysfunctional timing/change detection network underlies the cognitive impairment observed in SZ.
  • Autores: Alustiza Quintana, Irene Lucila; Garces, M. S.; Ortuno, M.; et al.
    Revista: SCHIZOPHRENIA BULLETIN
    ISSN 0586-7614 Vol.44 N° Supl.1. 2018 págs. S352
  • Autores: Popova, V.; Daly, E.; Trivedi, M.; et al.
    Revista: BIOLOGICAL PSYCHIATRY
    ISSN 0006-3223 Vol.83 N° 9 2018 págs. S390

Proyectos desde 2018

  • Título: Redes cerebrales de procesamiento temporal en pacientes estables con esquizofrenia frente a trastorno bipolar
    Código de expediente: PI17/00240
    Investigador principal: FELIPE ORTUÑO SANCHEZ-PEDREÑO.
    Financiador: INSTITUTO DE SALUD CARLOS III
    Convocatoria: AES2017 PROYECTOS DE INVESTIGACIÓN
    Fecha de inicio: 01-01-2018
    Fecha fin: 30-06-2022
    Importe concedido: 54.450,00 €
    Fondos FEDER: SI
  • Título: Papel de HDAC5 y SIRT2 en el grado de severidad de la depresión y en la eficacia clínica de los antidepresivos en pacientes de Navarra
    Código de expediente: 81/2017
    Investigador principal: ROSA MARIA TORDERA BAVIERA.
    Financiador: GOBIERNO DE NAVARRA
    Convocatoria: 2017 GN SALUD
    Fecha de inicio: 16-12-2017
    Fecha fin: 31-12-2021
    Importe concedido: 90.000,00 €
    Fondos FEDER: NO