Detalle Publicación

Thymidylate synthase polymorphisms in genomic DNA as clinical outcome predictors in a European population of advanced non-small cell lung cancer patients receiving pemetrexed

Autores: Arévalo Vázquez, Estefanía; Castañón Álvarez, Eduardo; López Erdozain, María Inés; Salgado Garrido, Josefa; Collado, V.; Santisteban Eslava, Marta; Rodríguez, M.; Martín Chacón, Patricia; Zubiri Oteiza, Leyre; Patiño García, Ana; Rolfo, C.; Gil Bazo, Ignacio
Título de la revista: JOURNAL OF TRANSLATIONAL MEDICINE
ISSN: 1479-5876
Volumen: 12
Páginas: 98
Fecha de publicación: 2014
Resumen:
In our series, 3R/3R polymorphism correlated with a superior OS. Also, this polymorphism, when associated to wild type EGFR, was related to a higher ORR to pemetrexed. Toxicity was not significantly correlated with a specific TS genotype.
DOI: https://doi.org/10.1186/1479-5876-12-98.
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