Detalle Publicación

ARTÍCULO
Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism
Título de la revista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN: 0066-4804
Volumen: 58
Número: 7
Páginas: 4227 - 4229
Fecha de publicación: 2014
Resumen:
Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.