Detalle Publicación


Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects

Autores: Schuerholz, T.; Dömming, S.; Hornef, M.,; Dupont, A.; Kowalski, I.; Kaconis, Y.; Heinbockel, L.; Andrä, J.; Garidel, P.; Gutsmann, T.; David, S.; Sánchez Gómez, Susana; Martínez de Tejada de Garaizábal, Guillermo; Brandenburg, K.
Título de la revista: CURRENT DRUG TARGETS
ISSN: 1389-4501
Volumen: 13
Número: 9
Páginas: 1131 - 1137
Fecha de publicación: 2012
The bacterial cell wall represents the primary target for antimicrobial agents. Microbial destruction is accompanied by the release of potent immunostimulatory membrane constituents. Both Gram-positive and Gram-negative bacteria release a variety of lipoproteins and peptidoglycan fragments. Gram-positive bacteria additionally provide lipoteichoic acids, whereas Gram-negative bacteria also release lipopolysaccharide (LPS, endotoxin), essential component of the outer leaflet of the bacterial cell wall and one of the most potent immunostimulatory molecules known. Immune activation therefore can be considered as an adverse effect of antimicrobial destruction and killing during anti-infective treatment. In contrast to antibiotics, the use of cationic amphiphilic antimicrobial peptides allows both effective bacterial killing and inhibition of the immunostimulatory effect of the released bacterial membrane constituents. The administration of antimicrobial peptides alone or in combination with antibiotic agents thus represents a novel strategy in the antiinfective treatment with potentially important beneficial aspects. Here, data are presented which describe immunological and clinical aspects of the use of antimicrobial peptides (AMPs) as therapeutic agents to treat bacterial infection and neutralize the immunostimulatory activity of released cell wall constituents.