Detalle Publicación


Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults

Autores: Miranda Hermsdorff, Helen Hermana; Volp, AC; Puchau de Lecea, María Blanca; Barbosa, KB; Zulet Alzórriz, María de los Ángeles; Bressan, J; Martínez Hernández, Alfredo
Título de la revista: INFLAMMATION RESEARCH
ISSN: 1023-3830
Volumen: 61
Número: 5
Páginas: 427 - 435
Fecha de publicación: 2012
This cross-sectional study assessed the potential contribution of gender, body fat distribution, and their interactions to some inflammatory marker concentrations [C-reactive protein (CRP), complement factor 3 (C3), and ceruloplasmin (Cp)] in young adults. Measurements included body composition, lifestyle features, blood biochemical and selected inflammatory markers on 317 healthy subjects [122 males/195 females; 22 +/- A 3 years; 22.1 +/- A 2.8 kg/m(2) (mean +/- SD)]. Women had significantly higher CRP and Cp concentrations than men. No gender difference was noted in C3 concentrations. In a multivariate model of the whole sample, body fat (BF), waist circumference (WC) and the sex x WC interaction term presented the highest R (2) for variance of CRP (11%), C3 (2%), and Cp (12%), respectively. In regression models separated by sex, BF was the adiposity indicator that explained the variability of CRP in men (13%) and women (7%). WC was the only variable significantly associated with C3 concentrations in women (3%). BF presented the highest partial R (2) for Cp in men (8%) and WC in women (16%). Our findings indicate a relevant interaction between gender and body fat distribution on the variance of CRP, C3, and Cp concentrations in apparently healthy young adults.