Detalle Publicación


Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders

Autores: Mundiñano, IC; Caballero, MC; Ordoñez Camblor, Cristina; Hernández Sánchez, María; Di Caudo, C; Marcilla García, Irene; Erro, M.E.; Tuñon, MT; Luquin Piudo, María Rosario Isabel
Título de la revista: ACTA NEUROPATHOL
ISSN: 0001-6322
Volumen: 122
Número: 1
Páginas: 61 -74
Fecha de publicación: 2011
Using stereological techniques we found an increased number of dopaminergic periglomerular neurons in the OB of AD, PD and FTD patients when compared with age-matched controls. Moreover, volumetric measurements of OBs showed a significant decrease only in AD patients, while the OB volume was similar to control in PD or FTD cases. The increased dopaminergic tone created in the OBs of these patients could reflect a compensatory mechanism created by the early degeneration of other neurotransmitter systems and might contribute to the olfactory dysfunction exhibited by patients with neurodegenerative disorders