Detalle Publicación


Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial

Autores: Pérez-Simón, JA.; López Villar, Olga; Andreu Oltra, Enrique José; Rifón Roca, José Juan; Muntion, Sandra; Díez Campelo, Sandra; Sánchez-Guijo, Fermín M.; Martínez, Carmen; Valcárcel, Dávid; Cañizo, CD
Título de la revista: HAEMATOLOGICA
ISSN: 1138-0381
Volumen: 96
Número: 7
Páginas: 1072-1076
Fecha de publicación: 2011
This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for the treatment of refractory acute or chronic graft-versus-host disease. Twenty-eight expansions were started. In 22, a minimum of more than 1x106 mesenchymal stem cells/kg were obtained after a median of 26 days; this threshold was not obtained in the remaining cases. Ten patients received cells for the treatment of refractory or relapsed acute graft-versus-host disease and 8 for chronic disease. One patient treated for acute graft-versus-host disease obtained a complete response, 6 had a partial response and 3 did not respond. One of the chronic patients achieved complete remision, 3 a partial response, and 4 did not respond. The current study supports the use of this approach in less heavily treated patients for both acute and chronic graft-versus-host disease.