Detalle Publicación

ARTÍCULO
Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo
Autores: Sánchez Gómez, Susana; Japelj, B.; Jerala, R; Moriyón Uría, Ignacio; Fernández Alonso, Mirian; Leiva León, José; Blondelle, SE; Andrä, J; Brandenburg, K; Lohner, K; Martínez de Tejada de Garaizábal, Guillermo
Título de la revista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN: 0066-4804
Volumen: 55
Número: 1
Páginas: 218 - 228
Fecha de publicación: 2011
Resumen:
A subinhibitory concentration of compound P2-15 or P2-27 sensitized P. aeruginosa to most classes of antibiotics tested and counteracted several mechanisms of antibiotic resistance, including loss of the OprD porin and overexpression of several multidrug efflux pump systems. Using a mouse model of lethal infection, we demonstrated that whereas P2-15 and erythromycin were unable to protect mice when administered separately, concomitant administration of the compounds afforded long-lasting protection to one-third of the animals