Detalle Publicación

Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin

Título de la revista: ONCOIMMUNOLOGY
ISSN: 2162-4011
Volumen: 1
Número: 1
Páginas: 97 - 99
Fecha de publicación: 2012
Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8+ T cells vs. T regulatory and myeloid-derived suppressor cells.