Detalle Publicación

Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

Autores: Unzu Ezquerro, Carmen; Hervas Stubbs, Sandra; Sampedro Pascual, Ana; Mauleón Mayora, Itsaso; Mancheño, U.; Alfaro Alegría, Carlos; de Salamanca, R. E.; Benito Boillos, Alberto; Beattie, S. G.; Petry, H.; Prieto Valtueña, Jesús María; Melero Bermejo, Ignacio; Fontanellas Roma, Antonio
Título de la revista: Journal of Translational Medicine
ISSN: 1479-5876
Volumen: 10
Páginas: 222
Fecha de publicación: 2012
Resumen:
These results indicate that our transient and intensive pharmacological immunosuppression fails to improve AAV5-based liver gene transfer in non-human primates. The reasons include an incomplete restraint of humoral immune responses to viral capsids that interfere with repeated gene transfer in addition to an intriguing MMF-dependent drug-mediated interference with liver transgene expression.
Enlace DADUN: http://hdl.handle.net/10171/23057
DOI: https://doi.org/ 10.1186/1479-5876-10-122.
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