Detalle Publicación

ARTÍCULO

Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion

Autores: Castillo Martín, I. (Autor de correspondencia); Ribate Villamón, E.; Muñoz Calabuig, M.; Santillana Sanz, G.; Such Taboada, E.; Mora Castera, E.; Calasanz Abinzano, María José; Irigoyen Barranco, A.; Nieto Collado, R.; Vara Pampliega, M.; Blanco, M. L.; Álvarez de Andrés, S.; Pérez de Oteyza, J.; Bernal del Castillo, T.; Granada Font, I.; Jerez Cayuela, A.; Diez-Campelo, M.; Abellán Sánchez, R.; Solano Vercet, C.; Tormo Díaz, M.
Título de la revista: CANCER MEDICINE
ISSN: 2045-7634
Volumen: 12
Número: 16
Páginas: 16788 - 16792
Fecha de publicación: 2023
Resumen:
BackgroundIn myelodysplastic neoplasms (MDS), the 20q deletion [del(20q)] is a recurrent chromosomal abnormality that it has a high co-occurrence with U2AF1 mutations. Nevertheless, the prognostic impact of U2AF1 in these MDS patients is uncertain and the possible clinical and/or prognostic differences between the mutation type and the mutational burden are also unknown. MethodsOur study analyzes different molecular variables in 100 MDS patients with isolated del(20q). Results & ConclusionsWe describe the high incidence and negative prognostic impact of U2AF1 mutations and other alterations such as in ASXL1 gene to identify prognostic markers that would benefit patients to receive earlier treatment.
DOI: https://doi.org/10.1002/cam4.6300
Impacto:
Google Scholar