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ARTÍCULO

Comparative effects of glucagon-like peptide-1 receptors agonists, 4-dipeptidyl peptidase inhibitors, and metformin on metabolic syndrome

Autores: Bouzas, C.; Pastor, R.; García, S.; Monserrat-Mesquida, M.; Martínez González, Miguel Ángel; Salas-Salvado, J.; Corella, D.; Goday, A.; Martínez Hernández, Alfredo; Alonso-Gómez, Á. M.; Fernández-Barceló, O.; Vioque, J.; Romaguera, D.; López-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Serra-Majema, L.; Riquelme-Gallegop, B.; Martín-Sánchez, V.; Pinto, X.; Delgado-Rodríguez, M.; Matia, P.; Vidal, J.; Cárdenas-Salas, J. J.; Daimiel, L.; Ros, E.; Toledo Atucha, Estefanía; Manzanares, J. M.; González-Monge, I.; Muñoz, M. A.; Martínez-Urbistondo, D.; Tojal-Sierra, L.; Muñoz-Bravoaf, C.; Miralles-Gisbert, S.; Martín, M.; García-Ríos, A.; Castro-Barquero, S.; Fernández-García, J. C.; Santos-Lozano, J. M.; Basterra-Gortari, F. J.; Gutiérrez-Carrasquilla, L.; Guillem-Saiz, P.; Satorres, A.; Abete Goñi, Itziar; Sorto-Sánchez, C.; Diez Espino, Javier; Babio, N.; Fito, M.; Tur, J. A. (Autor de correspondencia)
Título de la revista: BIOMEDICINE AND PHARMACOTHERAPY
ISSN: 0753-3322
Volumen: 161
Páginas: 114561
Fecha de publicación: 2023
Resumen:
Aims: To assess the comparative effects of glucagon-like peptide-1 receptor agonists (GLP-1RA), 4-dipeptidyl peptidase inhibitors (DPP-4I), and metformin treatment during one year on metabolic syndrome (MetS) com-ponents and severity in MetS patients. Methods: Prospective study (n = 6165 adults) within the frame of PREDIMED-Plus trial. The major end-point was changes on MetS components and severity after one-year treatment of GLP-1RA, DPP-4I, and metformin. Anthropometric measurements (weight, height and waist circumference), body mass index (BM), and blood pressure were registered. Blood samples were collected after overnight fasting. Plasma glucose, glycosylated hemoglobin (HbA1c), plasma triglycerides and cholesterol were measured. Dietary intakes as well as physical activity were assessed through validated questionnaires.Results: MetS parameters improved through time. The treated groups improved glycaemia compared with un-treated (glycaemia Delta untreated:-1.7 mg/dL(+/- 13.5); Delta metformin: -2.5(+/- 23.9) mg/dL; Delta DPP-4I: -4.5(+/- 42.6); mg/dL Delta GLP-1RA: -4.3(+/- 50.9) mg/dL; and HbA1c: Delta untreated: 0.0(+/- 0.3) %; Delta metformin: -0.1(+/- 0.7) %; Delta DPP-4I: -0.1(+/- 1.0) %; Delta GLP-1RA: -0.2(+/- 1.2) %. Participants decreased BMI and waist circumference. GLP-1RA and DPP-4I participants registered the lowest decrease in BMI (Delta untreated:-0.8(+/- 1.6) kg/m2; Delta metformin: -0.8(+/- 1.5) kg/m2; Delta DPP-4I: -0.6(+/- 1.3) kg/m2; Delta GLP-1RA: -0.5(+/- 1.2) kg/m2. and their waist circumference (Delta untreated:-2.8(+/- 5.2) cm; Delta metformin: -2.6(+/- 15.2) cm; Delta DPP-4I: -2.1(+/- 4.8) cm; Delta GLP-1RA: -2.4(+/- 4.1) cm.Conclusion: In patients with MetS and healthy lifestyle intervention, those treated with GLP-1RA and DPP-4I obtained better glycemic profile. Anthropometric improvements were modest.
DOI: https://doi.org/10.1016/j.biopha.2023.114561
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