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Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status

Autores: Khoury, N.; Martínez, M. Á. (Autor de correspondencia); Paz-Graniel, I.; Martínez González, Miguel Ángel; Corella, D.; Castaner, O.; Martínez Hernández, Alfredo; Alonso-Gómez, Á. M.; Warnberg, J.; Vioque, J.; Romaguera, D.; López-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Serra-Majem, J. L.; Bueno-Cavanillas, A.; Tur, J. A.; Cinza-Sanjurjo, S.; Pinto, X.; Gaforio, J. J.; Matia-Martín, P.; Vidal, J.; Vázquez, C.; Daimiel, L.; Ros, E.; Sayon Orea, María del Carmen; Sorli, J. V.; Pérez-Vega, K. A.; García-Ríos, A.; Gómez-Bellvert, N.; Gómez-Gracia, E.; Zulet Alzórriz, María de los Ángeles; Chaplin, A.; Casas, R.; Salcedo-Bellido, I.; Tojal-Sierra, L.; Bernal-López, M. R.; Vázquez Ruiz, Zenaida; Asensio, E. M.; Goday, A.; Peña-Orihuela, P. J.; Signes-Pastor, A. J.; García-Arellano, A.; Fito, M.; Babio, N.; Salas-Salvado, J. (Autor de correspondencia)
Título de la revista: ENVIRONMENTAL RESEARCH
ISSN: 0013-9351
Volumen: 227
Páginas: 115697
Fecha de publicación: 2023
Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited.Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population.Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and pro-spective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models.Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (beta-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumfer-ence (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, par-ticipants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (beta-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015).Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/ obesity. Further large prospective studies using a different population with longer follow-up periods are war-ranted in the future to strengthen our results.