Detalle Publicación


Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project

Autores: Gibbons, C. (Autor de correspondencia); O'Hara, B.; O'Connor, D.; Hardman, C.; Wilton, M.; Harrold, J. A.; Almirón Roig, Eva; Navas Carretero, Santiago; Hodgkins, C. E.; Nazare, J. A.; Alligier, M.; Martínez Hernández, Alfredo; Scott, C.; Kjølbæk, L.; Normand, M.; Rannou, C.; Blaak, E. E.; Feskens, E.; Moshoyiannis, H.; Raben, A.; Halford, J. C. G.; Beaulieu, K.; Finlayson, G.
Título de la revista: BMJ OPEN
ISSN: 2044-6055
Volumen: 12
Número: 12
Páginas: e063903
Fecha de publicación: 2022
IntroductionIntake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes.Methods and analysisA work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25-35kg/m(2); aged 18-60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14.Ethics and disseminationThe trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive.Trial registration numberNCT04633681.