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Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

Autores: Bullon Vela, Maria Vanessa (Autor de correspondencia); Xu, Y.F.; Razquin Burillo, Cristina; Abete Goñi, Itziar; Zulet Alzórriz, María de los Ángeles; Martínez González, Miguel Ángel; Buil Cosiales, Pilar; Vitelli-Storelli, F.; Martin Sánchez, V.; Vázquez Ruiz, Zenaida; Sayon Orea, María del Carmen; Domínguez Fernández, María Teresa; Cid Canda, María Concepción; Estruch, R.; Lamuela-Raventos, R. M.; Fito, M.; Blanchart, G.; Tur, J. A.; Romaguera, D.; Konieczna, J.; Pinto, X.; Daimiel, L.; Rodríguez-Mateos, A.; Martínez Hernández, Alfredo
Título de la revista: FOOD & FUNCTION
ISSN: 2042-6496
Volumen: 14
Número: 2
Páginas: 1011 - 1023
Fecha de publicación: 2023
Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvencion con DIeta MEDiterranea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7 '-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (B-per 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (B-per 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (B-per 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.