Detalle Publicación


Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome

Autores: Valle-Hita, C.; Becerra-Tomás, N.; Díaz-López, A. (Autor de correspondencia); Vázquez Ruiz, Zenaida; Megías, I.; Corella, D.; Goday, A.; Martínez Hernández, Alfredo; Alonso-Gómez, A. M.; Warnberg, J.; Vioque, J.; Romaguera, D.; López-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Serra-Majem, L.; Bueno-Cavanillas, A.; Tur, J. A.; Martín-Sánchez, V.; Pinto, X.; Gaforio, J. J.; Matía-Martín, P.; Vidal, J.; Amengual-Galbarte, A.; Daimiel, L.; Ros, E.; García-Arellano, A.; Barragan, R.; Fito, M.; Pena-Orihuela, P. J.; Asencio-Aznar, A.; Gómez-Gracia, E.; Martínez Urbistondo, Diego; Morey, M.; Casas, R.; Garrido-Garrido, E. M.; Tojal-Sierra, L.; Damas-Fuentes, M.; Goñi, E.; Ortega-Azorín, C.; Castaner, O.; García-Ríos, A.; Gisbert-Selles, C.; Sayon Orea, María del Carmen; Schroder, H.; Salas-Salvado, J.; Babio, N.
Título de la revista: FRONTIERS IN NUTRITION
ISSN: 2296-861X
Volumen: 9
Páginas: 986190
Fecha de publicación: 2022
BackgroundDiets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). MethodsOlder adults with overweight/obesity and metabolic syndrome (mean age 65 +/- 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed >= 10% eGFR decline or >= 10% UACR increase. ResultsAfter multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, beta: -0.64 ml/min/1.73 m(2); 95% CI: -1.21 to -0.08 and NEAP, beta: -0.56 ml/min/1.73 m(2); 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing >= 10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and >= 10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. ConclusionsHigher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome.