Resumen: The placement of a Hypoglossal Nerve Stimulation Implant (HNSI) is a surgical technique, which requires specialized training by the surgeon. As it is already known, in medicine all treatments must be individualized and specifically in this case, treatment and care of every patient with OSA should be carried out in an interdisciplinary and an integral way. The existence of preset guidelines for patient selection pursue to get the same results and guarantee the best outcome. The aim of this chapter is to discuss special situations that may be encountered when choosing the right candidate for surgery, diverse conditions that may need to be changed during surgery, and follow-up that may need to be individualized to obtain the best benefits.