Detalle Publicación


Linking dietary methyl donors, maternal separation, and depression

Libro: The neuroscience of depression: Genetics, cell biology, neurology, behavior, and diet
Lugar de Edición: Oxford
Editorial: Elsevier
Fecha de publicación: 2021
Página Inicial - Final: 473 - 483
ISBN: 978-0-12-817935-2
Resumen: In animal and human studies, there is an increasing evidence implicating stress in the etiology of depression. Stressful adverse events in early life may increase vulnerability to affective disorders, mainly depression, in adult life. Epigenetics play a crucial role in the regulation of gene activity and dysregulation of the epigenome by stress and could result in changes of gene activity that may induce depression. This chapter aims to summarize the main published findings about the relationship between stress and depression, and the purported underlying involvement of epigenetic mechanisms. It is described here the potential impact of nutritional strategies using methyl-donor compounds, such as folate, choline, betaine, vitamin B12, or B6 that might be used in order to prevent the development of depressive symptoms.