Resumen: Vitamin A is an essential fat-soluble vitamin with a myriad of functions including cell differentiation, redox homeostasis, growth and immune functions. Thereby, systemic inflammation has been linked with oxidative stress and has been also associated with reduced serum concentrations of vitamin A, owing to a reduced liver production of transport proteins, increased turnover of antioxidant vitamins, or a shift in tissue distribution. In this context, several studies have suggested a decrease in adiposity measurements related to the intake of antioxidants, vitamins and other related foodstuff. Moreover, adipose tissue is a target for the action of retinoic acid. Brown adipose tissue is a main site of adaptive thermogenesis and, as such, it is likely to be involved in the control of energy efficiency and body weight maintenance. In this context, white and brown adipose tissues are major sites of storage of vitamin A derivatives (retinoids). Furthermore, antioxidant dietary intake has proven its importance in the risk to develop obesity-related disorders and clinical complications. These findings support a relevant role for the antioxidants intake in the putative decrease of chronic disease manifestations and other features related to oxidative stress.