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Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Autores: Valle-Hita, C.; Díaz-López, A.; Becerra-Tomás, N. (Autor de correspondencia); Martínez González, Miguel Ángel; Ruiz García, V.; Corella, D.; Goday, A.; Martínez Hernández, Alfredo; Alonso-Gómez, A. M.; Warnberg, J.; Vioque, J.; Romaguera, D.; López-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Serra-Majem, L.; Cano-Ibáñez, N.; Tur, J. A.; Rubín-García, M.; Pinto, X.; Delgado-Rodríguez, M.; Matía-Martín, P.; Vidal, J.; Fontao, S. M.; Daimiel, L.; Ros, E.; Toledo Atucha, Estefanía; Sorlí, J. V.; Roca, C.; Abete Goñi, Itziar; Moreno-Rodríguez, A.; Crespo-Oliva, E.; Candela-García, I.; Morey, M.; García-Ríos, A.; Casas, R.; Fernández-García, J. C.; Santos-Lozano, J. M.; Diez Espino, Javier; Ortega-Azorín, C.; Comas, M.; Zulet Alzórriz, María de los Ángeles; Sorto-Sánchez, C.; Ruiz-Canela, Miguel; Fitó, M.; Salas-Salvadó, J.; Babio, N.
ISSN: 1436-6207
Volumen: 61
Número: 6
Páginas: 3095 - 3108
Fecha de publicación: 2022
Purpose To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). Methods We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m(2)) or >= 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Results Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (beta: 1.87 ml/min/1.73m(2); 95% CI: 1.00-2.73) and had lower odds of >= 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (beta: - 0.87 ml/min/1.73m(2); 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). Conclusions Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. Trial Registration Number: ISRCTN89898870 (Data of registration: 2014).