Detalle Publicación

ARTÍCULO
Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population
Autores: Camacho-Barcia, L.; García-Gavilán, J.; Martínez González, Miguel Ángel; Fernández-Aranda, F.; Galie, S.; Corella, D.; Cuenca-Royo, A.; Romaguera, D.; Vioque, J.; Alonso-Gómez, A. M.; Warnberg, J.; Martínez Hernández, Alfredo; Serra-Majem, L.; Estruch, R.; Bernal-López, M. R.; Lapetra, J.; Pinto, X.; Tur, J. A.; García-Ríos, A.; Bueno-Cavanillas, A.; Delgado-Rodríguez, M.; Matía-Martín, P.; Daimiel, L.; Martín-Sánchez, V.; Vidal, J.; Vázquez, C.; Ros, E.; Ruiz-Canela, Miguel; Sorli, J. V.; De La Torre, R.; Konieczna, J.; Oncina-Canovas, A.; Tojal-Sierra, L.; Pérez-López, J.; Abete Goñi, Itziar; Sánchez-Villegas, A.; Casas, R.; Muñoz-Garach, A.; Santos-Lozano, J. M.; Bouzas, C.; Razquin Burillo, Cristina; Martínez-Lacruz, R.; Castañer, O.; Yáñez, A. M.; Valls-Enguix, R.; Bello-Mora, M. C.; Basterra Gortari, Francisco Javier; Basora, J.; Salas-Salvadó, J. (Autor de correspondencia); Bullo, M. (Autor de correspondencia)
Título de la revista: AGE AND AGEING
ISSN: 0002-0729
Volumen: 51
Número: 2
Páginas: afab246
Fecha de publicación: 2022
Lugar: WOS
Resumen:
Background In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests. Methods In 5,533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 +/- 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake. Results After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median [IQR]; 194.4 mu g/d [120.9, 373.1]) was inversely associated with a Mini-Mental State Examination (MMSE) score <= 24 (OR [95% CI]; 0.53 [0.35, 0.79] P for trend = 0.002) compared with a decrease in the intake of vitamin K (median [IQR]; -97.8 mu g/d [-292.8, -51.5]). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR [95% CI]; 0.69 [0.51, 0.94] P for trend = 0.019) was found. Conclusions An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk.