Detalle Publicación


Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: a cohort study from the PREDIMED trial

Autores: Laguna, J. C. (Autor de correspondencia); Alegret, M.; Cofan, M.; Sánchez Tainta, Ana; Díaz-López, A.; Martínez González, Miguel Ángel; Sorlí, J. V.; Salas-Salvadó, J.; Fito, M.; Alonso-Gómez, A. M.; Serra-Majem, L.; Laperra, J.; Fiol, M.; Gómez-Gracia, E.; Pinto, X.; Muñoz, M. A.; Castañer, O.; Ramírez-Sabio, J. B.; Portu, J. J.; Estruch, R.; Ros, E. (Autor de correspondencia)
Título de la revista: CLINICAL NUTRITION
ISSN: 0261-5614
Volumen: 40
Número: 10
Páginas: 5269 - 5277
Fecha de publicación: 2021
Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mor-tality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 +/- 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality.