Detalle Publicación


International clinical practice guidelines for the treatment and prophylaxis of thrombosis associated with central venous catheters in patients with cancer

Autores: Debourdeau, P.; Farge, D. (Autor de correspondencia); Beckers, M. ; Baglin, C. ; Bauersachs, R. M. ; Brenner, B. ; Brilhante, D. ; Falanga, A.; Gerotzafias, G. T.; Haim, N.; Kakkar, A. K. ; Khorana, A. A.; Lecumberri Villamediana, Ramón; Mandala, M.; Marty, M. ; Monreal, M. ; Mousa, S. A.; Noble, S.; Pabinger, I. ; Prandoni, P. ; Prins, M. H.; Qari, M. H.; Streiff, M. B.; Syrigos, K.; Büller, H. R.; Bounameaux, H.
ISSN: 1538-7933
Volumen: 11
Número: 1
Páginas: 71 - 80
Fecha de publicación: 2013
Background: Although long-term indwelling central venous catheters (CVCs) may lead to pulmonary embolism (PE) and loss of the CVC, there is lack of consensus on management of CVC-related thrombosis (CRT) in cancer patients and heterogeneity in clinical practices worldwide. Objectives: To establish common international Good Clinical Practices Guidelines (GCPG) for the management of CRT in cancer patients. Methods: An international working group of experts was set up to develop GCPG according to an evidence-based medicine approach, using the GRADE system. Results: For the treatment of established CRT in cancer patients, we found no prospective randomized studies, two non-randomized prospective studies and one retrospective study examining the efficacy and safety of low-molecular-weight heparin (LMWH) plus vitamin K antagonists (VKAs). One retrospective study evaluated the benefit of CVC removal and two small retrospective studies were on thrombolytic drugs. For the treatment of symptomatic CRT, anticoagulant treatment (AC) is recommended for a minimum of 3 months; in this setting, LMWHs are suggested. VKAs can also be used, in the absence of direct comparisons of these two types of anticoagulants in this setting [Guidance]. The CVC can be kept in place if it is functional, well-positioned and non-infected and there is good resolution under close surveillance; whether the CVC is kept or removed, no standard approach in terms of AC duration has been established [Guidance]. ...