Detalle Publicación

ARTÍCULO
Thermal characterization and stability evaluation of leishmanicidal selenocyanate and diselenide derivatives
Título de la revista: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
ISSN: 1388-6150
Volumen: 147
Número: 4
Páginas: 3127 - 3139
Fecha de publicación: 2022
Lugar: WOS
Resumen:
In this study, the thermal behavior of a series of leishmanicidal selenocyanate and diselenide biological active compounds has been studied by means of differential scanning calorimetry, X-ray diffraction and thermogravimetry in order to establish thermal stability criteria and investigate their polymorphism. Moreover, stability under acid, alkaline and oxidative media was tested using high-performance liquid chromatography with fluorescence detection. The results of the experiments show that there are five types of polymorphic behaviors for the studied compounds. In addition, relationship is found among stability and a series of structural effects and stress conditions of compounds.