Detalle Publicación

ARTÍCULO
Selenium as an interesting option for the treatment of Chagas disease: A review
Título de la revista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN: 0223-5234
Volumen: 206
Páginas: 112673
Fecha de publicación: 2020
Resumen:
Chagas disease is one of the most prevalent tropical neglected diseases and causes high mortality and morbidity in endemic countries. Current treatments for this disease, nifurtimox and benznidazole, are ineffective in the chronic phase of the disease and produce severe adverse effects. Therefore, novel therapies are urgently required. The trace element selenium has an important role in human health, due to its antioxidant, antiinflammatory and pro-immune properties. Actually, its deficiency has been related to several diseases and supplementation with this element has been proven to be beneficial for multiple pathologies. Furthermore, the usefulness of organic-selenium compounds has been studied in many disorders, showing promising results. The aim of this review is to analyse the available literature regarding the role of selenium in Chagas disease in order to determine whether its use could be beneficial for the management of this pathology.