Detalle Publicación

Maqui, Calafate, and Blueberry fruits extracts treatments suppress the pathogenic interaction amongst human adipocytes and macrophages

Autores: Ovalle-Marin, A.; Reyes-Farias, M.; Vasquez, K. ; Parra-Ruiz, C. ; Quitral, V.; Jimenez, P. ; Garcia, L. ; Ramirez, L. A. ; Quezada, J. ; González Muniesa, Pedro; García Díaz, Diego Fernando (Autor de correspondencia)
Título de la revista: JOURNAL OF BERRY RESEARCH
ISSN: 1878-5093
Volumen: 10
Número: 3
Páginas: 531 - 545
Fecha de publicación: 2020
BACKGROUND: Obesity occurs due to a positive energy imbalance, leading to the expansion of adipose tissue. This phenomenon triggers a chronic low-grade inflammatory state, which is associated with comorbidities development. It is, therefore, of great interest to investigate new counteracting nutritional strategies. In this regard, polyphenol-rich Chilean native fruits, Aristotelia chilensis (Maqui) and Berberis microphylla (Calafate), and also the non-Chilean Vaccinium corymbosum (Blueberry), have been associated with antioxidant and anti-inflammatory features. OBJECTIVE: To evaluate Maqui, Calafate, and Blueberry aqueous extracts treatments on the pathogenic response of human activated macrophages and visceral adipocytes. METHODS: THP-1 monocyte human cell line and differentiated human visceral preadipocytes were activated (with lipopolysaccharide and TNF-a, for 48 and 24 h, respectively), and treated with the aqueous extracts. Inflammation and oxidative stress markers were assessed. RESULTS: Lower NO and IL-6 secretion, and inhibited apoptosis in activated macrophages, were observed. Also, decreased gene expression of MCP-1 and secretion of IL-6, inhibited apoptosis, and increased levels of GSH in activated adipocytes were detected. CONCLUSIONS: Maqui, Calafate, and Blueberry extracts showed anti-inflammatory and antioxidant responses in human macrophages and adipocytes.