Detalle Publicación

ARTÍCULO
Cyclodextrin-grafted nanoparticles as food preservative carriers
Título de la revista: INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN: 0378-5173
Volumen: 588
Páginas: 119664
Fecha de publicación: 2020
Lugar: WOS
Resumen:
Photocatalytic properties of titanium dioxide nanoparticles (TiO2 NPs) have encouraged their use as fillers in polymer-based nanocomposites for application in food packaging. The surface modification of TiO2 NPs with cyclodextrins (CDs) can improve their functionality in a large extent. With this purpose, sorbic acid (SA) and benzoic acid (BA), commonly used as antifungal and antibacterial food preservatives, respectively, have been encapsulated in CD-grafted NPs. Inclusion complex formation of SA and BA with a and beta CDs in water has been assessed first by means of H-1 NMR and UV-Vis spectroscopy to determine the affinity of the preservatives for the macrocycles and the stoichiometry of the complexes. The association constants of both preservatives were found to be lower for beta CD, however, the loading efficiency in beta CD-grafted NPs was higher than that exhibited by alpha CD-NPs. Release kinetics from the CD-grafted NPs have been carried out. In the case of SA, the alpha CD-grafted NPs showed a prolonged and sustained release profile, suggesting its application as microbial growth inhibition system if incorporated into packaging materials.