Detalle Publicación

ARTÍCULO
Optimal experimental design for cytogenetic dose-response calibration curves
Autores: Higueras, M. (Autor de correspondencia); Howes, A. ; López Fidalgo, Jesús Fernando
Título de la revista: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
ISSN: 0955-3002
Volumen: 96
Número: 7
Páginas: 894 - 902
Fecha de publicación: 2020
Lugar: WOS
Resumen:
Purpose:To introduce optimal experimental design techniques in the cytogenetic biological dosimetry practice. This includes the development of a new optimality criterion for the calibration of radiation doses. Materials and methods:The most typical optimal design criterion and the one developed in this research are introduced and applied in an example from the literature. In another example from the literature, a simulation study has been performed to compare the standard error of the dose estimation using different experimental designs. An RStudio project and a GitHub project have been developed to reproduce these results. Results:In the paper, it is observed that the application of optimal experimental design techniques can reduce the standard error of biodosimetric dose estimations. Conclusions:Optimal experimental design techniques jointly with practitioners' requirements may be applied. This practice would not involve an additional laboratory work.