Detalle Publicación


The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19

Autores: Armengaud, J. (Autor de correspondencia); Delaunay-Moisan, A. ; Thuret, J. Y.; van Anken, E. (Autor de correspondencia); Acosta-Alvear, D.; Aragón Amonarriz, Tomás; Arias, C.; Blondel, M.; Braakman, I. ; Collet, J. F. ; Courcol, R.; Danchin, A.; Deleuze, J. F.; Lavigne, J. P.; Lucas, S. ; Michiels, T. ; Moore, E. R. B.; Nixon-Abell, J.; Rossello-Mora, R.; Shi, Z. L. ; Siccardi, A. G. ; Sitia, R. ; Tillett, D.; Timmis, K. N.; Toledano, M. B.; van der Sluijs, P. ; Vicenzi, E.
ISSN: 1462-2912
Volumen: 22
Número: 6
Páginas: 1997 - 2000
Fecha de publicación: 2020
The current SARS-CoV-2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID-19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS-CoV-2 would offer significant relief, although vaccine developers have warned that design, testing and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (i), but the earliest vaccines were based on the live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (ii). What makes the current pandemic unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in detail how SARS-CoV-2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS-CoV-2 variants across the globe should be of key interest in our fight against the pandemic.