Detalle Publicación

Circulating microRNAs and their role in multiple myeloma

Autores: Federico, C.; Sacco, A.; Belotti, A.; Ribolla, R.; Cancelli, V. ; Giacomini, A. ; Ronca, R. ; Chiarini, M.; Imberti, L. ; Marini, M. ; Rossi, G.; Presta, M.; Paiva, Bruno; Roccaro, A. M. (Autor de correspondencia)
Título de la revista: NON-CODING RNA
ISSN: 2311-553X
Volumen: 5
Número: 2
Páginas: 37
Fecha de publicación: 2019
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also highlighted the importance of the functional cross-talk between the tumor clone and the surrounding bone marrow milieu, as a relevant player of MM pathogenesis. These findings have certainly enhanced our understanding of the underlying mechanisms supporting MM pathogenesis and disease progression. Within the specific field of small non-coding RNA-research, recent studies have provided evidence for considering microRNAs as a crucial regulator of MM biology and, in this context, circulating microRNAs have been shown to potentially contribute to prognostic stratification of MM patients. The present review will summarize the most recent studies within the specific topic of microRNAs and circulating microRNAs in MM.