Detalle Publicación


Immune Desertic Landscapes in Hepatocellular Carcinoma Shaped by beta-Catenin Activation

Título de la revista: CANCER DISCOVERY
ISSN: 2159-8274
Volumen: 9
Número: 8
Páginas: 1003 - 1005
Fecha de publicación: 2019
About one third of cases of hepatocellular carcinoma (HCC) show gain-of-function mutations of CTNNB1 (beta-catenin) that correlate with sparse intratumoral T-cell content, as observed previously in an ample spectrum of malignancies, and there is mounting preliminary evidence that such HCC cases are refractory to treatment with PD-1 checkpoint inhibitors. Elegant hepatocarcinogenesis experiments by in vivo gene transfer to mouse hepatocytes show that coexpression of active forms of beta-catenin result in poor T-cell infiltrates, faster progression in immunocompetent hosts, and unresponsiveness to immunotherapy with checkpoint inhibitors.