Detalle Publicación

ARTÍCULO
A quantitative method for the detection of muscle functional active and passive behavior recovery in models of damage-regeneration
Autores: Grasa, J.; Pérez Ruiz, Ana Isabel; Munoz, M. J. ; Soteras, F.; Bobadilla Muñoz, Miriam; Baraibar Churio, Arantxa; Prosper Cardoso, Felipe; Calvo, B. (Autor de correspondencia)
Título de la revista: PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS
ISSN: 1464-4207
Volumen: 233
Número: 8
Páginas: 1594 - 1603
Fecha de publicación: 2019
Lugar: WOS
Resumen:
Unlike other organs, skeletal muscle is endowed with a remarkable potential for regeneration that depends on the presence of satellite cells. Histological and functional (force generation) recoveries after muscle damage are not parallel processes. The aim of this study is to examine the in vivo contractile properties and in vitro passive stress-stretch behavior of muscle during degeneration-regeneration processes. Notexin was injected into rat tibialis anterior muscle, and functional recovery and histological changes were compared. We found that histological improvement of damaged muscle is delayed in comparison with its capacity to generate force. The elastic properties of muscle were not altered in agreement with the unchanged cross-linking index, probably as a consequence of the unaltered deposition of total collagen during degeneration-regeneration processes together with the maintenance of the ratio of collagens type I and III.