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Sleep Disordered Breathing Is Highly Prevalent in Patients with Lung Cancer: Results of the Sleep Apnea in Lung Cancer Study

Autores: Cabezas, E. ; Pérez Warnisher, María Teresa; Troncoso, M. F.; Gomez, T.; Melchor, R.; Pinillos, E. J.; El Hachem, A.; Gotera, C.; Rodriguez, P.; Fernandez, I. M. ; Martinez-Garcia, M. A.; Gonzalez-Mangado, N.; Peces-Barba, G.; Seijo Maceiras, Luis Miguel (Autor de correspondencia)
Título de la revista: RESPIRATION
ISSN: 0025-7931
Volumen: 97
Número: 2
Páginas: 119 - 124
Fecha de publicación: 2019
Background: Obstructive sleep apnea (OSA) has been linked to tumorigenesis and tumor progression. Objectives: The Sleep Apnea in Lung Cancer (SAIL) study (NCT02764866) was designed to determine the prevalence of OSA in patients with lung cancer. Methods: Cross-sectional study including consecutive patients with newly diagnosed lung cancer. All patients were offered home sleep apnea testing (HSAT) and administered a sleep-specific questionnaire prior to initiating oncologic treatment. Sleep study-related variables, symptoms, and epidemiologic data as well as cancer related variables were recorded. Results: Eighty-three patients were enrolled in the SAIL study. Sixty-six completed HSAT. The mean age was 68 +/- 11 years and 58% were male with a mean body mass index of 28.1 +/- 5.4. Forty-seven percent were current smokers, 42% former smokers, and 11% never smokers with a median tobacco consumption of 51 pack-years. Fifty percent had COPD with a mean FEV1 of 83 +/- 22.6% of predicted and a mean DLCO of 85.5 +/- 20.1%. Adenocarcinoma was the most common histologic type (46.7%), followed by squamous cell (16.7%) and small cell (16.7%). Most patients were diagnosed at an advanced stage (65% in stages III-IV). The vast majority (80%) had OSA (apnea-hypopnea index [AHI] > 5), and 50% had moderate to severe OSA (AHI > 15) with a mean Epworth Sleepiness Score of 7.43 +/- 3.85. Significant nocturnal hypoxemia was common (Median T90: 10.9% interquartile range 2.4-42.2). Conclusions: Sleep apnea and nocturnal hypoxemia are highly prevalent in patients with lung cancer. (C) 2018 S. Karger AG, Basel