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Engineering anti-myeloma responses using affinity-enhanced TCR-Engineered T cells

Autores: San Miguel Izquierdo, Jesús (Autor de correspondencia); Paiva, Bruno; Lasarte Sagastibelza, Juan José
Título de la revista: CANCER CELL
ISSN: 1535-6108
Volumen: 28
Número: 3
Páginas: 281 - 283
Fecha de publicación: 2015
Resumen:
NY-ESO-1 TCR-engineered T cells have shown activity in solid tumors. Recent work supports their use in multiple myeloma by showing that ex vivo antigen-specific expanded T cells traffic to and persist in bone marrow, are well tolerated, and produce promising response rates when infused after stem cell transplantation.
DOI: https://doi.org/10.1016/j.ccell.2015.08.009
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