Detalle Publicación


Reality of the emetogenic level of irinotecan

Título de la revista: SUPPORTIVE CARE IN CANCER
ISSN: 0941-4355
Volumen: 26
Número: 10
Páginas: 3441 - 3446
Fecha de publicación: 2018
Purpose. To assess the emetogenic potential of different chemotherapy (CT) regimens in daily clinical practice in an outpatient setting. To optimize antiemetic prophylaxis if necessary Methods. Prospective and retrospective review of the emetogenic potential of CT regimens used in adult patients in an outpatient setting Results. We assess the chemotherapy-induced nausea and vomiting (CINV) of 50 different CT regimens used on 157 different patients in an outpatient setting. We found that the CT usually classified as highly emetogenic, including cisplatin and anthracycline-cyclophosphamide combination, had the higher incidence of CINV (37.5 and 54.4% respectively). The antineoplastic drugs usually considered to be moderately emetogenic had, as expected, lower rates of emesis with the exception of irinotecan, which presented a pattern of nausea and/or vomiting (NV) similar to the highly emetogenic CTwith a global incidence of 48.5%. The appearance of emetic symptoms had impact on quality of life in 70% of the patients, with nausea being the main emetic symptom. Conclusion. Antiemetic prophylaxis for highly emetogenic CTcould be improve. Irinotecan CTregimens have a high emetogenic potential more than moderate and require more intensive antiemetic prophylaxis too.