Detalle Publicación


Intra-tumor heterogeneity in TP53 null high grade serous ovarian carcinoma progression

Autores: Mota, Alba; Carlos Trivino, Juan; Rojo-Sebastian, Alejandro; Martinez-Ramirez, Angel; Chiva de Agustín, Luis; González Martín, Antonio; Garcia, Juan F.; Garcia-Sanz, Pablo; Moreno-Bueno, Gema
Título de la revista: BMC CANCER
ISSN: 1471-2407
Volumen: 15
Páginas: 940
Fecha de publicación: 2015
Altogether, our results shed light on the clonal evolution of the distinct tumor regions identifying the most aggressive subpopulations and at least some of the genes that may be implicated in its progression and recurrence, and highlights the importance of considering intra-tumor heterogeneity when carrying out genetic and genomic studies, especially when these are aimed to diagnostic procedures or to uncover possible therapeutic strategies