Detalle Publicación

ARTÍCULO
All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS
Título de la revista: MOLECULAR AND CELLULAR ONCOLOGY
ISSN: 2372-3556
Volumen: 4
Número: 3
Páginas: e1314239
Fecha de publicación: 2017
Resumen:
KRAS proto-oncogene, GTPase (KRAS) remains refractory to current therapies. We devised an integrative cross-tumor approach to expose common core elements up-regulated in mutant KRAS cancers that could provide new treatment opportunities. This approach identified FOSL1 (Fos-like antigen 1) as a clinically and functionally relevant gene in mutant KRAS-driven lung and pancreatic cancers, and unveiled downstream transcriptional targets amenable to pharmacological inhibition