Detalle Publicación


The human parahippocampal region: I. Temporal pole cytoarchiectonic and MRI correlation

Autores: Blaizot, X.; Mansilla, F.; Insausti, A. M.; Constans, J. M.; Salinas Alamán, Ángel; Pro-Sistiaga, P.; Mohedano-Moriano, A.; Insausti, R.
Título de la revista: CEREBRAL CORTEX
ISSN: 1047-3211
Volumen: 20
Número: 9
Páginas: 2198 - 2212
Fecha de publicación: 2010
The temporal pole (TP) is the rostralmost portion of the human temporal lobe. Characteristically, it is only present in human and nonhuman primates. TP has been implicated in different cognitive functions such as emotion, attention, behavior, and memory, based on functional studies performed in healthy controls and patients with neurodegenerative diseases through its anatomical connections (amygdala, pulvinar, orbitofrontal cortex). TP was originally described as a single uniform area by Brodmann area 38, and von Economo (area TG of von Economo and Koskinas), and little information on its cytoarchitectonics is known in humans. We hypothesize that 1) TP is not a homogenous area and we aim first at fixating the precise extent and limits of temporopolar cortex (TPC) with adjacent fields and 2) its structure can be correlated with structural magnetic resonance images. We describe here the macroscopic characteristics and cytoarchitecture as two subfields, a medial and a lateral area, that constitute TPC also noticeable in 2D and 3D reconstructions. Our findings suggest that the human TP is a heterogeneous region formed exclusively by TPC for about 7 mm of the temporal tip, and that becomes progressively restricted to the medial and ventral sides of the TP. This cortical area presents topographical and structural features in common with nonhuman primates, which suggests an evolutionary development in human species.