Resumen: There is no dispute in neuroscience that structure and function are related, but it is difficult to identify how exactly this relationship occurs. The phrenological view advocates for the idea that each area of the brain corresponds to a particular function. This view then evolved into a modular view, meaning that each brain network corresponds to a singular function. But these views have serious limitations and a more systemic one is in order. It is thought that brain function is related to dynamic and temporary neural assemblies. What seems obvious is that the relationship between structure and function is not straightforward. In this article, we will see how the non-function of brain areas and the non-univocal relationship between structure and function can serve as an opportunity to offer a new concept, i.e., "functionalization", which the philosopher Leonardo Polo proposed. Polo understood functionalization as a part of function. We believe that the presence of this "intermediate element" can help to provide new insights into the relationship between structure and function.