Detalle Publicación

Dengue virus inhibits the production of type I interferon in primary human dendritic cells

Autores: Rodríguez Madoz, Juan Roberto; Bernal-Rubio, D.; Kaminski, D.; Boyd, K.; Fernandez-Sesma, A.
Título de la revista: JOURNAL OF VIROLOGY
ISSN: 0022-538X
Volumen: 84
Número: 9
Páginas: 4845 - 4850
Fecha de publicación: 2010
Dengue virus (DENV) infects human immune cells in vitro and likely infects dendritic cells (DCs) in vivo. DENV-2 productive infection induces activation and release of high levels of chemokines and proinflammatory cytokines in monocyte-derived DCs (moDCs), with the notable exception of alpha/beta interferon (IFN-alpha/beta). Interestingly, DENV-2-infected moDCs fail to prime T cells, most likely due to the lack of IFN-alpha/beta released by moDCs, since this effect was reversed by addition of exogenous IFN-beta. Together, our data show that inhibition of IFN-alpha/beta production by DENV in primary human moDCs is a novel mechanism of immune evasion.