Detalle Publicación

ARTÍCULO
Optimizing the test power for a radiation retention model in human body
Autores: Amo-Salas, M.; López Fidalgo, Jesús Fernando; Rodríguez-Díaz, J. M.
Título de la revista: PHARMACEUTICAL STATISTICS
ISSN: 1539-1604
Volumen: 9
Número: 1
Páginas: 55 - 66
Fecha de publicación: 2010
Resumen:
The model that describes the retention in lungs of radioisotope particles is studied in this paper, considering the situation of an accident in facilities that handle radioactive materials. Optimal times to make the bioassays are computed for D- and c-optimality, and efficiencies for the computed designs are provided and compared. Moreover, the test power is checked by means of simulations and replications. After that the inverse of the Fisher information matrix is compared to an estimation of the covariance matrix of the parameters. Finally, a study taking into consideration the randomness of the designs space is performed.