Design and manufacturing engineers are not fully aware of the different possibilities that PolyJet technology offers. The goal of this article is to provide the design and manufacturing engineers with greater knowledge about the final properties of parts printed with PolyJet rapid prototyping technology. This knowledge includes the effect of printing orientation and post-processing on the mechanical and surface properties of printed parts. Eighteen different samples considered all the possible printing orientations and the surface finishing treatments recommended by the manufacturer. These finishing properties include part printing using the matte/glossy option and removal of the support material using water pressure and/or a caustic soda bath. Tensile tests and surface roughness measurements were analysed for the printed samples using the statistical design of experiments in order to determinate the influence of the printing orientation and finishing properties on the results. These tests showed that the part orientation has a significant effect on elastic modulus and fracture stress while there is no statistical significance on ultimate tensile strength. With regard to the finish, none of the tensile test outputs showed significant differences. In terms of roughness, the analysis of variance indicated that position and finish presented statistically significant differences between the means of the three roughness directions. From all these experiences, it is possible to conclude that the glossy finish and the xy printing direction worked very well regarding roughness, whereas the critical load direction of the part should be placed along the x-axis when printing.