Detalle Publicación

ARTÍCULO
Molecular genetics of chondroid tumours
Autores: De Andrea, Carlos Eduardo; Hogendoorn, P. C. W.
Título de la revista: DIAGNOSTIC HISTOPATHOLOGY (OXFORD)
ISSN: 1756-2317
Volumen: 20
Número: 5
Páginas: 165 - 171
Fecha de publicación: 2014
Resumen:
Chondroid tumours comprise a heterogeneous group of lesions with diverse morphological features and clinical behaviour. Over the past decade, a substantial number of chondroid tumours have been shown to harbour specific genetic abnormalities. These genetic alterations can be divided into two groups: tumours with specific translocations, and tumours with specific gene mutations. These genetic events give not only important insight in the tumourigenesis of chondroid tumours but offers new possibilities for molecular diagnosis. Some of these specific genetic changes have been implemented in routine pathology. This review aims to highlight the molecular genetics of chondroid tumours and their diagnostic applications.