Detalle Publicación


Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma.

Autores: Bendandi, Maurizio; Marillonnet S; Kandzia R; Thieme F; Nickstadt A; Herz S; Fröde R; Inoges Sancho, Susana Inmaculada; López Díaz de Cerio, Ascensión; Soria Saldise, Elena; Villanueva Ruiz, Helena; Vancanneyt G; McCormick A; Tusé D; Lenz J; Butler-Ransohoff JE; Klimyuk V; Gleba Y
Título de la revista: ANNALS OF ONCOLOGY
ISSN: 0923-7534
Volumen: 21
Número: 12
Páginas: 2420-7
Fecha de publicación: 2010
This manufacturing process is reliable and robust, the manufacturing time from biopsy to vaccine is <12 weeks and the expression and purification of antigens require only 2 weeks. The process is also broadly applicable for manufacturing monoclonal antibodies in plants, providing 50- to 1000-fold higher yields than alternative plant expression methods.