Detalle Publicación

Prefrontal activity and COMT genotype effects in schizophrenia.

Autores: López García, María del Pilar; Young Espinoza, Leslie Erika; García, D.; García de Eulate Ruiz, María Reyes; Marín Méndez, Juan; Ortuño Sánchez-Pedreño, Felipe; Zubieta Zarraga, José Luis
Título de la revista: SCHIZOPHRENIA RESEARCH
ISSN: 0920-9964
Volumen: 117
Número: 2-3
Páginas: 352-353
Fecha de publicación: 2010
Resumen:
Dopamine levels in the prefrontal cortex (PFC) seem to play a crucial role in cognitive function in schizophrenia. The COMT enzyme has a functional polymorphism (val158met): val/val individuals have a higher functioning enzyme leading to lower dopamine levels in PFC and therefore to poorer cognitive performance. This genetic polymorphism could mediate the relationship between dopamine levels, cognitive functioning and neural activity of PFC. We used global neuropsychological and specific cognitive assessments and fMRI to study the influence of COMT genotype on cognition and brain function in schizophrenia spectrum disorder patients, relatives and healthy control subjects.
DOI: https://doi.org/ http://dx.doi.org/10.1016/j.schres.2010.02.618
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