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ARTÍCULO

Intensive weight-loss lifestyle intervention using Mediterranean Diet and COVID-19 risk in older adults: secondary analysis of PREDIMED-Plus Trial

Autores: Shyam, S. (Autor de correspondencia); Garcia-Gavilan, J. F.; Paz-Graniel, I.; Gaforio, J. J.; Martínez González, Miguel Ángel; Corella, D.; Martínez Hernández, Alfredo; Alonso-Gomez, A. M.; Warnberg, J.; Vioque, J.; Romaguera, D.; Lopez-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Serra-Majem, J. L.; Bueno-Cavanillas, A.; Tur, J. A.; Sanchez, V. M.; Pinto, X.; Matia-Martin, P.; Vidal, J.; Alcarria, M. D.; Daimiel, L.; Ros, E.; Fernandez-Aranda, F.; Nishi, S. K.; Garcia-Regata, O.; Pérez Araluce, Rafael María; Asensio, E. M.; Castaner, O.; Garcia-Rios, A.; Oncina-Canovas, A.; Bouzas, C.; Zulet Alzórriz, María de los Ángeles; Rayo, E.; Casas, R.; Martin-pelaez, S.; Tojal-Sierra, L.; Bernal-Lopez, M. R.; Carlos, S.; Sorli, J. V.; Goday, A.; Pena-Orihuela, P. J.; Pastor-Morel, A.; Eguaras, S.; Zomeno, M. D.; Delgado-Rodriguez, M.; Babio, N.; Fito, M.
Título de la revista: JOURNAL OF NUTRITION HEALTH AND AGING
ISSN: 1279-7707
Volumen: 27
Número: 12
Páginas: 1153 - 1161
Fecha de publicación: 2023
Resumen:
ObjectivesWe tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.DesignSecondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial.SettingCommunity-dwelling, free-living participants in PREDIMED-Plus trial.Participants6,874 Spanish older adults (55-75 years, 49% women) with overweight/obesity and metabolic syndrome.InterventionParticipants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations.MeasurementsCOVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk.ResultsOverall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)).ConclusionsThere was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/ obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks.