Publicaciones

Estas son las últimas publicaciones en las que ha participado la sección de Toxicología del Departamento de Farmacología y Toxicología de la Universidad de Navarra:

  • Koppen G, Azqueta A, Pourrut B, Brunborg G, Collins AR, Langie SAS. "The next three decades of the comet assay: a report of the 11th International Comet Assay Workshop"  Mutagenesis 32(2): 397-408.
  • Marin de Mas I, Marin S, Pachon G, Rodriguez-Prados JC, Vizan P, Centelles JJ, Tauler R, Azqueta A, Selivanov V, Lopez de Cerain A, Cascante M. "Unveiling the metabolic changes on muscle cell metabolism underlying p-phenylenediamine toxicity" Front Mol Biosci 4: 8.
  • Iglesias T, Dusinska M, El Yamani N, Irache JM, Azqueta A, Lopez de Cerain A. "In vitro evaluation of the genotoxicity of poly(anhydride) nanoparticles designed for oral drug delivery" Int J Pharm, 523(1): 418-426.
  • 2016

    • Pastor L, Vettorazzi A, Campion J, Cordero P, Lopez de Cerain A. Gene expression kinetics of renal transporters induced by ochatoxin A in male and female F344 rats. Food Chem Toxicol, 98(pt B): 169-178.

    • Quiliano M, Mendoza A, Fong KY, Pabon A, Goldfarb NE, Fabing I, Vettorazzi A, López de Cerain A, Dunn BM, Garavito G, Wright DW, Deharo E, Perez-Silanes S, Aldana I, Galiano S. Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration. International Journal for Parasitology: Drugs and Drug Resistance, 6: 184-198.

    • Moreno-Viguri E, Jimenez Montes C, Martin-Escolano R, Santivañez-Veliz M, Martin-Montes A, Azqueta A, Jimenez-Lopez M, Zamora Ledesma S, Cirauqui N, Lopez de Cerain A, Marin C, Sanchez-Moreno M, Perez-Silanes S. In vitro and in vivo anti-trypanosoma cruzi activity of new arylamine Mannich base-type derivatives. J Med Chem, 59: 10929-10945.

    • Azqueta A, Collins AR. Polyphenols and DNA damage: A mixed blessing. Nutrients, 8: 785-805.

    • Perez-Silanes S, Torres E, Arbillaga L, Varela J, Cerecetto H, Gonzalez M, Azqueta A, Moreno E. Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro anti Trypanosoma cruzi activity. Bioorganic & Medicinal Chemistry Letters, 26: 903-906.

    • Guada M, Lana H, Gil AG, Dios-Vieitez MdelC, Blanco-Prieto MJ. Cyclosporine A lipid nanoparticles for oral administration: Pharmacodynamics and safety evaluation. Eur J Pharmac Biopharmac, 8: 101-112.

  • 2015

    • Gil Royo AG, Arbillaga L, Lopez de Cerain A. Non-clinical toxicity studies on bioactive compounds within the framework of nutritional and  health claims. Int J Food Sci Nutr, 66(1): S13-S21.

    • Chaccour C, Barrio A, Gil Royo AG, Martinez Urbistondo D, Slater H, Hammann F, Del Pozo JL. Screening for an invermectin slow-release formulation suitable for malaria vector control. Int J Food Sci Nutr, 14: 102-107.

    • Corcuera L, Vettorazzi A, Arbillaga L, Perez N, Gil AG, Azqueta A, Gonzalez-Peñas E, Garcia Jalon JA, Lopez de Cerain A. Genotoxicity of aflatoxin B1 and ochratoxin A after simultaneous application of the in vivo micronucleus and comet assay. Food Chem Toxicol, 76: 116-124.

    •  Ojer P, Iglesias T, Azqueta A, Irache JM, Lopez de Cerain A. Toxicity evaluation of nanocarriers for the oral delivery of macromolecular drugs. Eur J Pharma Biopharm, 97(Pt A): 206-217.

    • Martin-Camean A, Puerto M, Jos A, Azqueta A, Iglesias-Linares A, Solano E, Camean AM. Preliminary study of genotoxicity evaluation of orthodontic miniscrews on human mucosa oral cells by the alkaline comet assay. Toxicol Mech Meth, 25(6): 487-493.

    • Goodson III WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain A, Lasfar A, Carnero A, Azqueta A, (et al). Assessing the carcinogenic potential of low dose exposures to chemical mixtures in the environment: the challenge ahead. Part of the special issue on : "Assessing the carcinogenic potential of low dose exposures to chemical mixtures in the environment". Carcinogenesis, 36 (1): 487-S254.

    • Langie SAS, Koppen G, Desaulniers D, Al-Mulla F, Al-Temaimi R, Amedei A, Azqueta A, Bisson WH, Brown D, Brunborg G, Charles AK, Chen T, Colacci A, Darroudi F, Forte S, Gonzalez L, Hamid RA, Knudsen LE, Leyns L, Lopez de Cerain A, (et al). Causes of genome instability: the effect of low doses chemicals exposures in modern society. Part of the special issue on: "Assessing the cardiogenic potential of low dose exposures to chemical mixtures in the environment". Carcinogenesis, 36 (1): S61-88.

    • Enciso JM, Sánchez O, López de Cerain A, Azqueta A. Does the duration of lysis affect the sensitivity of the in vitro alkaline comet assay?. Mutagenesis, 30(1): 21-28.

    • Huk A, Collins AR, El Yamani N, Porredon C, Azqueta A, de Lapuente J, Dusinska M. Critical factors to be considered when testing nanomaterials for genotoxicity with the comet assay. Mutagenesis, 30(1): 85-88.

    • Ibero-Baraibar I, Azqueta A, Lopez de Cerain A, Martinez JA, Zulet MA. Assesment of oxidised DNA bases using comet assay in middle-aged overweight/obese subject after following a hypocaloric diet supplemented with cocoa extract. Mutagenesis, 30(1): 139-146.

  • 2014

    • Ochratoxin A kinetics: a review of analytical methods and studies in rat model. Vettorazzi A, González-Peñas E, de Cerain AL. Food and Chemical Toxicology, 72: 273-288.

    • Base excision repair capacity in chronic renal failure patients undergoing hemodialysis treatment. Stoyanova E, Pastor S, Coll E, Azqueta A, Collins AR, Marcos R. Cell Biochemistry and Function 32: 177-182.

    • Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories. Godschalk RWL, Ersson C, Stępnik M, Ferlińska M, Palus J, Teixeira JP, Costa S, Jones GDD, Higgins JA, Möller L, Forchhammer L, Loft S, Lorenzo Y, Collins AR, van Schooten F-J, Laffon B, Valdiglesias V, Cooke M, Mistry V, Karbaschi M, Phillips DH, Sozeri O, Routledge MN, Nelson-Smith K, Riso P, Porrini M, López de Cerain A, Azqueta A, Matullo G, Allione A,  Møller P. Mutagenesis 29: 241-249.

    • Lipid nanoparticles protect from edelfosine toxicity in vivo. Beatriz Lasa-Saracíbar, María Ángela Aznar, Hugo Lana, Ismael Aizpún, Ana Gloria Gil, Maria J. Blanco-Prieto. International Journal of Pharmaceutics 474: 1-5.

  • 2013

    • "Enhancing the sensitivity of the comet assay as a genotoxicity test, by combining it with bacterial repair enzyme FPG".   Azqueta A, Arbillaga L, de Cerain AL, Collins A.  Mutagenesis, 28(3): 271-277 .  

    • "Validation of an antiviral assay method for quantifying IFN-alpha 5 activity in macaque and human serum" .  Arbillaga L, Murillo-Arbizu M, Gonzalez I, Gil AG, Vettorazzi A, Gonzalez-Penas E, Larrea E, de Cerain AL.   Bioanalysis, 5(3): 289-305 .

    • "Levels of ochratoxins in Mediterranean red wines". Remiro R, Irigoyen A, Gonzalez-Penas E, Lizarraga  E, de Cerain AL.   Food Control, 32(1): 63-68 . 

  • 2012

    • "Inter-laboratory variation in DNA damage using a standard comet assay protocol". Forchhammer L, Ersson C, Loft S, Möller L, Godschalk RWL, Shooten FJV, Jones GDD, Higgins JA, Cooke M, Mistry V, Karbaschi M, Collins AR, Azqueta A, Phillips DH, Sozeri O, Routledge MN, Nelson-Smith K, Riso P, Porrini M, Matullo G, Allione A, Stepnik M, Komorowska M, Teixeira JP, Costa S, Corcuera LA, López de Cerain A, Laffon B, Valdiglesias V, Møller P. Mutagenesis, doi: 10.1093/utge/ges032

    • "Donor cornea transfer from Optisol GS to organ culture storage: a two step procedure to increase donor tissue lifespan". Haug K, Azqueta A, Johnsen-Soriano S, Shahdadfar A, Drolsum LK, Moe MC, Røer M, Romero FJ, Collins AR, Nicolaissen B. Accepted in Acta Ophthalmologica, doi: 10.1111/j.1755-3768.2012.02390.x

    • "DNA damage in lens epithelium of cataract patients in vivo and ex vivo". Azqueta A, Osnes-Ringen O, Moe MC, Zetterström C, Røger M, Nicolaissen B, Collins AR. Acta Ophthalmologica, doi: 10.1111/j.1755-3768.2012.02500.x.

    • "Carotenoids and DNA damage". Azqueta A, Collins AR. Mutation Research 733(1-2), 4-13

    • "Effects of micronutrients on DNA repair". Collins AR, Azqueta A, Langie SA. European Journal of Nutrition 51(3), 261-279

    • "Co-ocurrence of type-A and type-B trichothecenes in barley from a northern region of Spain" Ibáñez-Vea M, González-Peñas E, Lizarraga E, López de Cerain A. Food Control 25, 81-88

    • "Co-ocurrence of aflatoxins, ochratoxin A and zearalenone in barley from a northern region of Spain" Ibáñez-Vea M, González-Peñas E, Lizarraga E, López de Cerain A. Food Chemistry 132(1), 35-42

    • "OTA-producing fungi in foodstuffs: a review". Amézqueta S, Schorr-Galindo S, Murillo-Arbizu M, González-Peñas E, López de Cerain A, Guiraud JP. Food Control 26(2), 259-268

    • "An approach to the toxicity and toxicokinetics of aflatoxin B1 and ochratoxin A after simultaneous oral administration to fasted F344 rats". Corcuera LA, Vettorazzi A, Arbillaga L, González-Peñas E, López de Cerain A. Food Chem Toxicol 50(10), 3440-3446

    • "A polyphenol-enriched cocoa extract reduces free radicals produced by mycotoxins". Corcuera LA, Amézqueta S, Arbillaga L, Vettorazzi A, Touriño S, Torres JL, López de Cerain A. Food Chem Toxicol 50(3-4), 989-995.

    • "Co-occurrence of mycotoxins in Spanish barley: A statistical overview".   Ibanez-Vea M, Gonzalez-Penas E, Lizarraga E, López de Cerain A.  Food Control 28(2): 295-298.

    • "A comparative performance test of standard, medium- and high-throughput comet assays".  Azqueta A, Gutzkow KB, Priestley CC, Meier S, Walker JS, Brunborg G, Collins AR. Toxicol In Vitro 27(2): 768-773.

  • 2011

    • "Towards a more reliable comet assay: optimising agarose concentration, unwinding time and electrophoresis conditions". Azqueta A, Gutzkow KB, Brunborg G, Collins AR. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 724, 41-45.

    • Kidney and liver disposition and distribution of ochratoxin A in male and female F344 rats. Vettorazzi A, Trocóniz IF, Gonzalez-Peñas E, Arbillaga L, Corcuera LA, Gil AG, López de Cerain A.  Food and Chemical Toxicology (49), 1935-1942.

    • "The influence of scoring methods on variability in results obtained with the comet assay". Azqueta A, Meier S, Priestley C, Gutzkow KB, Brunborg G, Sallette J, Soussaline F, Collins AR. Mutagenesis, 26, 393-399.

    • "3-Trifluoromethylquinoxaline N,N'-dioxides as anti-trypanosomatid agents. Identification of optimal anti-T cruzi agents and mechanism of action studies"
      Benítez D, Cabrera M, Hernández P, Boiani L, Lavaggi ML, Di Maio R, Yaluff G, Serna E, Torres S, Ferreira ME, Vera de Bilbao N, Torres E, Pérez-Silanes S, Solano B, Moreno E, Aldana I, López de Cerain A, Cerecetto H, González M, Monge A. Journal of Medicinal Chemistry, 54(10), 3624-3636.

    • "Both base excision repair and nucleotide excision repair in humans are influenced by nutritional factors"
      Brevik A, Karlsen A, Azqueta A, Tirado A, Blomhoff R, Collins AR. Cell Biochemistry & Function, 29, 36-42.

    • "Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopheroll analogs as potential new class of antiatherogenic agents". Cabrera M, López GV, Gómez LE, Breijo M, Pintos C, Botti H, Raymondo S, Vettorazzi A, López de Ceráin A, Monge A, Rubbo H, González M, Cerecetto H. Drug and Chemical Toxicology, 34, 285-293.

    • "DNA repair as a biomarker; further applications of the comet assay". Collins AR, Azqueta A. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 736, 122-129

    • "Ochratoxin A reduces aflatoxin B1 induced DNA damage detected by the comet assay in hepG2 cells"
      Corcuera LA, Arbillaga L, Vettorazzi A, Azqueta A, López de Cerain A. Food and Chemical Toxicology, 49, 2883-2889

    • "Validation of a UHPLC-FLD analytical method for the simultaneous quantification of aflatoxin B1 and ochratoxin A in rat plasma, liver and kidney". Corcuera LA, Ibáñez-Vea M, Vettorazzi A, González-Peñas E, López de Cerain A: . Journal of Chromatography B, 87, 2733-2740.

    • "Co-occurrence of aflatoxins, ochratoxin and zearalenone in breakfast cereals from spanish market"
      Ibáñez-Vea M, Martínez R, González-Peñas E, Lizarraga E, López de Cerain A. Food Control, 22, 1949-1955

    • "Novel Phenazine 5,10-Dioxides Release •OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo". Lavaggi ML, Cabrera M, Pintos C, Arredondo C, Pachón G, Rodríguez J, Raymondo S, Pacheco JP, Cascante M, Olea-Azar C, López de Ceráin A, Monge A, Cerecetto H, González M. ISRN Pharmacol (on line)

    • "The influence of sterilization with EnbioJet® microwave flow pasteurizer on composition and bioactivity of aronia and blueberry honeysuckle". Piasek A, Kusznirewicz B, Grzybowska I, Malinowska-Panczyk E, Piekarska A, Azqueta A, Collins AR, Namiesnik J, Bartoszek A. Journal of Food Composition and Analysis, 24, 880-888.

  • Libros

    • Azqueta A, Collins AR. "The comet assay: a sensitive and quantitative method for analysis of DNA damage" En Encyclopedia of analytical chemistry. John Wiley and Sons, 2011.

    • Azqueta A, Shaposhnikov S, Collins AR. "DNA repair measured by the comet assay" En DNA repair. Ed. In Tech, Croatia, 2011, 615-636.

    • Gil AG, López de Cerain A. "Estudios preclínicos en el desarrollo de agentes Anti-T cruzi. Estudios de toxicidad" En Enfermedad de Chagas: estrategia en la búsqueda de nuevos medicamentos. Una visión iberoamericana. Ed. Red Iberoaméricana de Investigación, Desarrollo e Innovación de Medicamentos Antichagásicos, 2011, 341-364. ISBN 978-607-95813-0-5.

    • Irache JM, Martin-Arbella N, Ojer P, Azqueta A, Lopez de Cerain A. "Toxicological aspects of polymer nanoparticles". Springer Switzerland, 2016. 521-550.

Contacto

Contacto:
Edificio de Investigación
C/ Irunlarrea, 1
31008 Pamplona
España